2,3-Dimethoxyphenylboronic acid
- Product Name
- 2,3-Dimethoxyphenylboronic acid
- CAS No.
- 40972-86-9
- Chemical Name
- 2,3-Dimethoxyphenylboronic acid
- Synonyms
- AKOS BRN-0202;3-Boronoveratrole;2,3-DimethoxyphenyL;2,3-DimethoxybenzeneboronicAci;2,3-dimethoxyphenylboronci acid;2,3-DIMETHOXYPHENYLBORONIC ACID;2,3-DIMETHOXYBENZENEBORONIC ACID;2,3-DiMethoxyphenylboronic acid 97%;B-(2,3-Dimethoxy-phenyl)boronic acid;2,3-Dimethoxyphenylboronic acid ,98%
- CBNumber
- CB6728027
- Molecular Formula
- C8H11BO4
- Formula Weight
- 181.98
- MOL File
- 40972-86-9.mol
2,3-Dimethoxyphenylboronic acid Property
- Melting point:
- 67-71 °C (lit.)
- Boiling point:
- 347.9±52.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 8.12±0.58(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- BRN
- 3051295
- InChI
- InChI=1S/C8H11BO4/c1-12-7-5-3-4-6(9(10)11)8(7)13-2/h3-5,10-11H,1-2H3
- InChIKey
- VREWSCMOGIXMDQ-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC(OC)=C1OC)(O)O
- CAS DataBase Reference
- 40972-86-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36/37-37
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 557730
- Product name
- 2,3-Dimethoxyphenylboronic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $83.7
- Updated
- 2025/07/31
- Product number
- D3853
- Product name
- 2,3-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- D3853
- Product name
- 2,3-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- 273035
- Product name
- 2,3-Dimethoxyphenylboronic acid
- Packaging
- 1g
- Price
- $322
- Updated
- 2021/12/16
- Product number
- D479203
- Product name
- 2,3-Dimethoxyphenylboronic acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
2,3-Dimethoxyphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
suzuki reaction
General Description
2,3-Dimethoxyphenylboronic acid is a useful research chemical for organic synthesis and other chemical processes.
Synthesis
91-16-7
121-43-7
40972-86-9
To a solution of N,N,N',N'-tetramethylethylenediamine (6.1 mL, 40.5 mmol) in diethyl ether (100 mL) was added n-butyllithium (26 mL, 1.6 M in hexane, 41.6 mmol) dropwise at 0° C. After 30 min the reaction mixture was cooled to -78° C., 1,2-dimethoxybenzene (5.0 g, 36.4 mmol) and stirred for 3 h at this temperature. Subsequently, trimethyl borate (9.7 mL, 86.4 mmol) was added, the cold bath was removed and the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was cooled to 0 °C, 150 mL of aqueous 2 M hydrochloric acid was added and stirred for 3 hours. The mixture was extracted with ethyl acetate (3 x 20 mL), the organic layers were combined, dried over magnesium sulfate, filtered, and concentrated in vacuum to afford 2,3-dimethoxyphenylboronic acid (1 g, 37% yield) as white crystals. 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline (256 mg, 1.02 mmol) and 2,3-dimethoxyphenylboronic acid (370 mg, 2.03 mmol) were dissolved in DMSO (2 mL), and 2 M aqueous K3PO4 (1 mL) was added, followed by PdCl2 (dppf) (50 mg). The mixture was transferred to a microwave reaction tube and microwave irradiated at 120 °C for 15 min. After completion of the reaction, it was cooled to room temperature and the crude product was purified by column chromatography to afford 6-(2,3-dimethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline (190 mg, 61% yield) as a white solid. The product was brominated with N-bromosuccinimide, followed by a coupling reaction with 2-phenylethanethiol as described in Example 7 to give 45 mg of 2,3-dimethoxyphenylboronic acid as an oil.
References
[1] Chemical Communications, 1999, # 22, p. 2259 - 2260
[2] Patent: WO2004/18429, 2004, A2. Location in patent: Page 85
[3] Bulletin de la Societe Chimique de France, 1973, p. 767 - 769
2,3-Dimethoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-Dimethoxyphenylboronic acid Suppliers
- Tel
- --
- Fax
- --
- brunschwig@brunschwig.nl
- Country
- The Netherlands
- ProdList
- 4996
- Advantage
- 67
View Lastest Price from 2,3-Dimethoxyphenylboronic acid manufacturers
- Product
- (2,3-Dimethoxyphenyl)boronic acid 40972-86-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-23
- Product
- (2,3-Dimethoxyphenyl)boronic acid 40972-86-9
- Price
- US $30.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-26
- Product
- 2,3-Dimethoxyphenylboronic acid 40972-86-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10