Fenoldopam
- Product Name
- Fenoldopam
- CAS No.
- 67227-56-9
- Chemical Name
- Fenoldopam
- Synonyms
- CS-1332;Corlopam;SKF-82526;FENOLDOPAM;SKF-82526-J;CORLOPAM MESYLATE;Fenoldopam, Corlopam;Fenoldopam USP/EP/BP;Fenoldopam hydrochlo;FenoldopamMesylateBase
- CBNumber
- CB6729842
- Molecular Formula
- C16H16ClNO3
- Formula Weight
- 305.76
- MOL File
- 67227-56-9.mol
Fenoldopam Property
- Boiling point:
- 522.6±50.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >12 mg/mL
- pka
- 8.50±0.40(Predicted)
- form
- Powder
- color
- off-white
- CAS DataBase Reference
- 67227-56-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36-42/43
- Safety Statements
- 22-26-36/37/39
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 1659
- Product name
- Fenoldopamhydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 1659
- Product name
- Fenoldopamhydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $818
- Updated
- 2021/12/16
- Product number
- 011983
- Product name
- Fenoldopam
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- 011985
- Product name
- Fenoldopam Hydrochloride
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- I745
- Product name
- Fenoldopam
- Packaging
- 10mg
- Price
- $229
- Updated
- 2021/12/16
Fenoldopam Chemical Properties,Usage,Production
Originator
Corlopam,Pharmaforce, Inc.
Uses
Dopamine D1-receptor agonist. Antihypertensive.
Uses
dopamine receptor agonists
Uses
The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Fenoldopam is a selective dopamine 1 receptor agonist with diuretic and properties (2,3).
Definition
ChEBI: Fenoldopam is a benzazepine. It has a role as a dopaminergic antagonist, a vasodilator agent, an alpha-adrenergic agonist, a dopamine agonist and an antihypertensive agent.
Manufacturing Process
2-Chloro-3,4-dimethoxyphenethylamine (1.0 g) was reacted with 0.70 g of pmethoxystyrene
oxide to give the hydroxyphenethylamine; m.p. 118.5-121°C.
This compound (2.16 g) was stirred at room temperature in 15 ml of
trifluoroacetic acid with 4 drops of conc. sulfuric acid. After purification over a
silica gel column with chloroform, 10% methanol/chloroform as eluates, was
obtained 6-chloro-7,8-dimethoxy-1-p-methoxyphenyl-2,3,4,5-tetrahydro-1H-
3-benzazepine (0.78 g), m.p. 143-145°C.
The trimethoxy product (0.87 g, 2.50 mmoles) in 25 ml of dry methylene
chloride was cooled in an ice-methanol bath and 12.5 ml (25.0 mmoles) of
boron tribromide in methylene chloride was added dropwise. After stirring for
4 hours, the mixture was cooled in an ice bath while methanol was carefully
added to give 0.37 g of 6-chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-
tetrahydro-1H-3-benzazepine hydrobromide, m.p. 215°C.
The base was regenerated from the hydrobromide salt using sodium carbonate solution in 85% yield. Treating the base with various acids gave the
following salts: dl-tartrate, fumarate, hydrochloride, sulfate, and the most
water soluble one, the methanesulfonate, m.p. 272°C.
brand name
Corlopam (Hospira).
Therapeutic Function
Antihypertensive
Biological Activity
Selective D 1 -like dopamine receptor partial agonist (EC 50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α 2 -adrenoceptor antagonist in vitro (K i = 15-25 nM).
Fenoldopam Preparation Products And Raw materials
Raw materials
Preparation Products
Fenoldopam Suppliers
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View Lastest Price from Fenoldopam manufacturers
- Product
- Fenoldopam 67227-56-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10
- Product
- Fenoldopam 67227-56-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09
- Product
- Fenoldopam 67227-56-9
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20