ChemicalBook > CAS DataBase List > 6-Aminothiouracil

6-Aminothiouracil

Product Name
6-Aminothiouracil
CAS No.
1004-40-6
Chemical Name
6-Aminothiouracil
Synonyms
AB 48;NSC 1587;NSC 202018;NSC 321193;NSC 321194;AURORA 13795;6-Aminothiouracil;4-Amino-2-thiouracil;6-AMINO-2-THIOURACIL;6-amino-2-thio-uraci
CBNumber
CB6730983
Molecular Formula
C4H5N3OS
Formula Weight
143.17
MOL File
1004-40-6.mol
More
Less

6-Aminothiouracil Property

Melting point:
>300?C (dec.)
Boiling point:
246.5°C
Density 
1.397 (estimate)
refractive index 
1.7490 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
crystalline solid
pka
7.92±0.20(Predicted)
color 
Off-white
Water Solubility 
256.3mg/L(25 ºC)
InChI
InChI=1S/C4H5N3OS/c5-2-1-3(8)7-4(9)6-2/h1H,(H4,5,6,7,8,9)
InChIKey
YFYYRKDBDBILSD-UHFFFAOYSA-N
SMILES
C1(=S)NC(N)=CC(=O)N1
CAS DataBase Reference
1004-40-6(CAS DataBase Reference)
NIST Chemistry Reference
Uracil, 6-amino-2-thio-(1004-40-6)
EPA Substance Registry System
6-Amino-2-thiouracil (1004-40-6)
More
Less

Safety

Hazard Codes 
Xi
RTECS 
UW0495000
HS Code 
2933599590
Toxicity
LD50 ipr-mus: 370 mg/kg ARZNAD 31,1713,81
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
A0791
Product name
4-Amino-6-hydroxy-2-mercaptopyrimidine
Packaging
25G
Price
$29
Updated
2025/07/31
Biosynth Carbosynth
Product number
FA11937
Product name
6-Amino-4-hydroxy-2-mercaptopyrimidine
Packaging
100g
Price
$139
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA11937
Product name
6-Amino-4-hydroxy-2-mercaptopyrimidine
Packaging
25g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
7175AF
Product name
4-Amino-6-hydroxy-2-mercaptopyrimidine
Packaging
1g
Price
$63
Updated
2021/12/16
AK Scientific
Product number
3276AH
Product name
4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate
Packaging
1g
Price
$63
Updated
2021/12/16
More
Less

6-Aminothiouracil Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

LAbelled derivative of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Synthesis

17356-08-0

105-56-6

1004-40-6

General procedure for the synthesis of 6-amino-2-thiouracil from the compound (CAS: 17356-08-0) and ethyl cyanoacetate: 101.5 g (1.88 mol) of sodium methanol was accurately weighed in a reaction flask containing 3 L of 670 g ethanol at room temperature. Subsequently, 67.3 g (0.88 mol) of thiourea was added and stirred until complete dissolution. The reaction mixture was heated to 55 °C and then 100 g (0.884 mol) of ethyl cyanoacetate was slowly added. The heating was continued to reflux and the reflux reaction was maintained for 4.5 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was cooled to 15 °C. The reaction mixture was filtered and the filter cake was washed once with 170 g ethanol. The washed filter cake was transferred to a 3 L reaction flask and appropriate amount of water was added, followed by 1.3 kg of water and stirred until complete dissolution. The pH of the solution was adjusted to 4 by slowly adding acetic acid at 20 °C, at which point a large amount of solid precipitated. The solid product was collected by filtration using a suction filter. The filter cake was dried at 45 °C overnight to give a final product of 115.4 g of 6-amino-2-thiouracil in 91.7% yield.

References

[1] Patent: CN106008633, 2016, A. Location in patent: Paragraph 0065; 0066; 0067; 0068
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 662 - 668
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4612 - 4621
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 18, p. 3389 - 3395
[5] Australian Journal of Chemistry, 2007, vol. 60, # 2, p. 120 - 123

6-Aminothiouracil Preparation Products And Raw materials

Raw materials

Ethanol Sodium Ethyl cyanoacetate Thiourea

Preparation Products

4,5-Diamino-6-hydroxypyrimidine 6-Mercaptopurine 6-Hydroxypurine 6-AMINO-5-BROMO-2-(ETHYLTHIO)PYRIMIDIN-4-OL
More
Less

6-Aminothiouracil Suppliers

Austria 1 Canada 2 China 153 Europe 1 Germany 3 India 3 South Korea 1 Ukraine 2 United Kingdom 13 United States 28 Global 207
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376080562
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
884
Advantage
60
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Suzhou Guide Fine Material Co.Ltd.
Tel
0512-66627360 13914021065
Fax
0512-66627360
Email
706938434@qq.com
Country
China
ProdList
237
Advantage
60
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9979
Advantage
58
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
XiaMeng Kang Auke Pharma Co., Ltd
Tel
0086-592-7270133 612
Fax
0086-592-7689136
Email
1934992149@qq.com
Country
China
ProdList
170
Advantage
50
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9942
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10110
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13856024262
Email
kuer@kuerhuaxue.com
Country
China
ProdList
2992
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10330
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8596
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9988
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
More
Less

View Lastest Price from 6-Aminothiouracil manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
6-Aminothiouracil 1004-40-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
6-Aminothiouracil 1004-40-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

1004-40-6, 6-AminothiouracilRelated Search:

2-Ethylhexyl mercaptoacetate 4-Aminopyrimidine 2-Aminopyrimidine Sodium thioglycolate 3-Mercaptopropionic acid 6-Mercaptopurine Calcium thioglycolate Acetaminophen Mercaptoacetic acid Glycine Diethylaminosulfur trifluoride 6-Aminocaproic acid 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL 1-PHENYL-2-THIOUREA POTASSIUM THIOGLYCOLATE 4-Hydroxy-6-aminopyrimidine 2-Aminophenol Tris(hydroxymethyl)aminomethane

  • 4-Amino-2-thiouracil
  • 4-AMINO-6-HYDROXY-2-MERCAPTOPYRIMIDINE
  • AURORA 13795
  • OTAVA-BB BB7013910011
  • 6-AMINO-2-THIOXO-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE
  • 6-AMINO-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE
  • 6-Aminothiouracil
  • 6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinone
  • 2-Mercapto-6-aminouracil
  • 2-MERCAPTO-4-HYDROXY-6-AMINO-PYRIMIDINE
  • 6-AMINO-4-KETO-2-THIOPYRIMIDINE
  • 6-Amino-2-sulfanylidene-1H-pyrimidin-4-one
  • 6-AMINO-2-THIOURACIL
  • 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo- (9CI)
  • 4-Amino-2-mercaptouracil
  • NSC 1587
  • NSC 202018
  • NSC 321193
  • NSC 321194
  • 6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one 97%
  • 6-Amino-2-thiouracil, 4-Amino-6-hydroxypyrimidine-2-thiol
  • 6-Amino-2,3-dihydro-2-thioxo-1H-pyrimidin-4-one
  • 6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one
  • 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo-
  • 6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinon
  • 6-amino-2-thio-uraci
  • 6-Amino-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
  • AB 48
  • Pyrimidin-4-ol, 6-amino-2-mercapto-
  • 6-Amino-2-mercapto-pyrimidin-4-ol ,97%
  • 2-Thioxo-6-amino-1,2-dihydropyrimidine-4(3H)-one
  • 6-Amino-2-mercaptopyrimidin-4(1H)-one
  • 6-Amino-2-thioxo-1,2-dihydropyrimidine-4(3H)-one
  • 4-Amino-2-thiouracil Discontinued See: A630455
  • 4-amino-6-hydroxy-2-thiopyrimidine
  • 6-Amino-2-mercapto-pyrimidin-4-ol ,98%
  • 2-thio-6-aminouracil
  • 1004-40-6
  • C4H5N3OS
  • Heterocycle-Pyrimidine series
  • Chemical Amines
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Sulfur & Selenium Compounds
  • Imidazoles & Benzimidazoles
  • Pyrazines, Pyrimidines & Pyridazines
  • PYRIMIDINE
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Amines
  • Pyrazines, Pyrimidines & Pyridazines
  • Imidazoles & Benzimidazoles