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6-Aminothiouracil

Product Name
6-Aminothiouracil
CAS No.
1004-40-6
Chemical Name
6-Aminothiouracil
Synonyms
AB 48;NSC 1587;NSC 202018;NSC 321193;NSC 321194;AURORA 13795;6-Aminothiouracil;4-Amino-2-thiouracil;6-AMINO-2-THIOURACIL;6-amino-2-thio-uraci
CBNumber
CB6730983
Molecular Formula
C4H5N3OS
Formula Weight
143.17
MOL File
1004-40-6.mol
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6-Aminothiouracil Property

Melting point:
>300?C (dec.)
Boiling point:
246.5°C
Density 
1.397 (estimate)
refractive index 
1.7490 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
crystalline solid
pka
7.92±0.20(Predicted)
color 
Off-white
Water Solubility 
256.3mg/L(25 ºC)
InChI
InChI=1S/C4H5N3OS/c5-2-1-3(8)7-4(9)6-2/h1H,(H4,5,6,7,8,9)
InChIKey
YFYYRKDBDBILSD-UHFFFAOYSA-N
SMILES
C1(=S)NC(N)=CC(=O)N1
CAS DataBase Reference
1004-40-6(CAS DataBase Reference)
NIST Chemistry Reference
Uracil, 6-amino-2-thio-(1004-40-6)
EPA Substance Registry System
6-Amino-2-thiouracil (1004-40-6)
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Safety

Hazard Codes 
Xi
RTECS 
UW0495000
HS Code 
2933599590
Toxicity
LD50 ipr-mus: 370 mg/kg ARZNAD 31,1713,81
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A0791
Product name
4-Amino-6-hydroxy-2-mercaptopyrimidine
Packaging
25G
Price
$29
Updated
2025/07/31
Biosynth Carbosynth
Product number
FA11937
Product name
6-Amino-4-hydroxy-2-mercaptopyrimidine
Packaging
100g
Price
$139
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA11937
Product name
6-Amino-4-hydroxy-2-mercaptopyrimidine
Packaging
25g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
7175AF
Product name
4-Amino-6-hydroxy-2-mercaptopyrimidine
Packaging
1g
Price
$63
Updated
2021/12/16
AK Scientific
Product number
3276AH
Product name
4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate
Packaging
1g
Price
$63
Updated
2021/12/16
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6-Aminothiouracil Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

LAbelled derivative of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Synthesis

17356-08-0

105-56-6

1004-40-6

General procedure for the synthesis of 6-amino-2-thiouracil from the compound (CAS: 17356-08-0) and ethyl cyanoacetate: 101.5 g (1.88 mol) of sodium methanol was accurately weighed in a reaction flask containing 3 L of 670 g ethanol at room temperature. Subsequently, 67.3 g (0.88 mol) of thiourea was added and stirred until complete dissolution. The reaction mixture was heated to 55 °C and then 100 g (0.884 mol) of ethyl cyanoacetate was slowly added. The heating was continued to reflux and the reflux reaction was maintained for 4.5 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was cooled to 15 °C. The reaction mixture was filtered and the filter cake was washed once with 170 g ethanol. The washed filter cake was transferred to a 3 L reaction flask and appropriate amount of water was added, followed by 1.3 kg of water and stirred until complete dissolution. The pH of the solution was adjusted to 4 by slowly adding acetic acid at 20 °C, at which point a large amount of solid precipitated. The solid product was collected by filtration using a suction filter. The filter cake was dried at 45 °C overnight to give a final product of 115.4 g of 6-amino-2-thiouracil in 91.7% yield.

References

[1] Patent: CN106008633, 2016, A. Location in patent: Paragraph 0065; 0066; 0067; 0068
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 662 - 668
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4612 - 4621
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 18, p. 3389 - 3395
[5] Australian Journal of Chemistry, 2007, vol. 60, # 2, p. 120 - 123

6-Aminothiouracil Preparation Products And Raw materials

Raw materials

Ethanol Sodium Ethyl cyanoacetate Thiourea

Preparation Products

4,5-Diamino-6-hydroxypyrimidine 6-Mercaptopurine 6-Hydroxypurine 6-AMINO-5-BROMO-2-(ETHYLTHIO)PYRIMIDIN-4-OL
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6-Aminothiouracil Suppliers

Austria 1 Canada 2 China 153 Europe 1 Germany 3 India 3 South Korea 1 Ukraine 2 United Kingdom 13 United States 28 Global 207
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376080562
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
884
Advantage
60
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
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View Lastest Price from 6-Aminothiouracil manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
6-Aminothiouracil 1004-40-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
6-Aminothiouracil 1004-40-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

1004-40-6, 6-AminothiouracilRelated Search:

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  • 4-Amino-2-thiouracil
  • 4-AMINO-6-HYDROXY-2-MERCAPTOPYRIMIDINE
  • AURORA 13795
  • OTAVA-BB BB7013910011
  • 6-AMINO-2-THIOXO-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE
  • 6-AMINO-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE
  • 6-Aminothiouracil
  • 6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinone
  • 2-Mercapto-6-aminouracil
  • 2-MERCAPTO-4-HYDROXY-6-AMINO-PYRIMIDINE
  • 6-AMINO-4-KETO-2-THIOPYRIMIDINE
  • 6-Amino-2-sulfanylidene-1H-pyrimidin-4-one
  • 6-AMINO-2-THIOURACIL
  • 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo- (9CI)
  • 4-Amino-2-mercaptouracil
  • NSC 1587
  • NSC 202018
  • NSC 321193
  • NSC 321194
  • 6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one 97%
  • 6-Amino-2-thiouracil, 4-Amino-6-hydroxypyrimidine-2-thiol
  • 6-Amino-2,3-dihydro-2-thioxo-1H-pyrimidin-4-one
  • 6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one
  • 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo-
  • 6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinon
  • 6-amino-2-thio-uraci
  • 6-Amino-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
  • AB 48
  • Pyrimidin-4-ol, 6-amino-2-mercapto-
  • 6-Amino-2-mercapto-pyrimidin-4-ol ,97%
  • 2-Thioxo-6-amino-1,2-dihydropyrimidine-4(3H)-one
  • 6-Amino-2-mercaptopyrimidin-4(1H)-one
  • 6-Amino-2-thioxo-1,2-dihydropyrimidine-4(3H)-one
  • 4-Amino-2-thiouracil Discontinued See: A630455
  • 4-amino-6-hydroxy-2-thiopyrimidine
  • 6-Amino-2-mercapto-pyrimidin-4-ol ,98%
  • 2-thio-6-aminouracil
  • 1004-40-6
  • C4H5N3OS
  • Heterocycle-Pyrimidine series
  • Chemical Amines
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Sulfur & Selenium Compounds
  • Imidazoles & Benzimidazoles
  • Pyrazines, Pyrimidines & Pyridazines
  • PYRIMIDINE
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Amines
  • Pyrazines, Pyrimidines & Pyridazines
  • Imidazoles & Benzimidazoles