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ChemicalBook > CAS DataBase List > 8-Methoxypsoralen

8-Methoxypsoralen

Description References
Product Name
8-Methoxypsoralen
CAS No.
298-81-7
Chemical Name
8-Methoxypsoralen
Synonyms
XANTHOTOXIN;METHOXSALEN;Uvadex;Xanthoxin;AMMOIDIN;9-Methoxy-7H-furo[3,2-g]chromen-7-one;8-MOP;Oxsoralen;Methoxalen;Methoxsale
CBNumber
CB6733540
Molecular Formula
C12H8O4
Formula Weight
216.19
MOL File
298-81-7.mol
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8-Methoxypsoralen Property

Melting point:
148-150 °C(lit.)
Boiling point:
276.6°C (rough estimate)
Density 
1.1344 (rough estimate)
refractive index 
1.4270 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: slightly soluble
form 
Needle-Like Crystals or Powder
color 
white to yellow
Water Solubility 
PRACTICALLY INSOLUBLE
Merck 
14,5988
BRN 
196453
LogP
1.523 (est)
CAS DataBase Reference
298-81-7(CAS DataBase Reference)
IARC
1 (Vol. 24, Sup 7, 100A) 2012
NIST Chemistry Reference
Methoxsalen(298-81-7)
EPA Substance Registry System
Methoxsalen (298-81-7)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-43-46-45-34
Safety Statements 
36/37-53-45-36/37/39-26
RIDADR 
3216
WGK Germany 
3
RTECS 
LV1400000
F 
10
TSCA 
Yes
HS Code 
29322090
Hazardous Substances Data
298-81-7(Hazardous Substances Data)
Toxicity
LD50 i.p. in rats: 470 ±30 mg/kg (Hakim)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3040
Product name
Methoxsalen
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$139
Updated
2024/03/01
Sigma-Aldrich
Product number
56448
Product name
Xanthotoxin
Purity
analytical standard
Packaging
50mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
1417001
Product name
Methoxsalen
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL89866
Product name
Xanthotoxin
Purity
phyproof? Reference Substance
Packaging
50MG
Price
$250
Updated
2023/01/07
TCI Chemical
Product number
X0009
Product name
Xanthotoxin
Purity
>98.0%(GC)
Packaging
100mg
Price
$16
Updated
2024/03/01
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8-Methoxypsoralen Chemical Properties,Usage,Production

Description

8-methoxypsoralen (also known as methoxsalen) is a naturally occurring furocoumarin compound existing in several species of plants such as Psoralea corylifolia. It is a photoactive substance that can form DNA adducts upon UVA irradiation. It is a drug used for the treatment of psoriasis, eczema, vitiligo, and some kinds of cutaneous lymphomas associated with the exposure of skin to the UVA or light from lamps or sunlight. Its mechanism of action is through inhibiting the synthesis of the deoxyribonucleic acid (DNA). After the activation, it can preferentially bind to the guanine and cytosine molecules of DNA, further leading to the cross-linking of DNA, thus inhibiting the DNA synthesis. It can further inhibit the RNA and protein synthesis at high concentration. It is extracted from Ammi majus.

References

https://www.drugbank.ca/drugs/DB00553
https://en.wikipedia.org/wiki/Methoxsalen

Description

8-Methoxypsoralen (8-MOP) and other psoralens are naturally found in plants, including common fruit and vegetable crops.

Chemical Properties

White to cream-colored, crystalline solid; odorless. Slightly soluble in alcohol; practically insoluble in water. Combustible.

Originator

Oxsoracen,Eider,US,1955

Uses

8-Methoxypsoralen, is used in Photochemotherapy (methoxsalen with long wave ultraviolet radiation) is indicated for the repigmentation of idiopathic vitiligo. It is also used in Photopheresis (methoxsalen with long wave ultraviolet radiation of white blood cells) is indicated for use with the UVAR* System in the palliative treatment of the skin manifestations of cutaneous T-cell lymphoma.

Uses

antipsoriatic, pigmentation agent

Uses

Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides.

Uses

For the treatment of psoriasis and vitiligo

Uses

A potent suicide inhibitor of cytochrome P-450.

Uses

Naturally occurring analog of psoralen. Use in treatment of psoriasis and mycosis fungoides

Indications

Methoxsalen has effects similar to those of trioxsalen. Methoxsalen is superior to trioxsalen in producing erythema and tanning and is the drug used in PUVA therapy. Methoxsalen is also available as a 1% lotion.

Definition

ChEBI: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.

Manufacturing Process

It has been found that the compound 8-geranoxy psoralen is present in citrus oils, particularly lemon and lime oils. This compound can be isolated from the oil by a process which involves primarily absorption on an adsorbent material followed by elution with a suitable solvent.
(A) Cleavage of 8-Geranoxypsoralen: 275 mg of 8-geranoxypsoralen was dissolved with mechanical stirring in 4 ml glacial acetic acid. After 10 minutes,one drop of concentrated sulfuric acid was added to the solution. In 4 minutes thereafter a light tan precipitate began to form. Stirring was continued for 35 minutes and the reaction mixture was refrigerated for one hour and 20 minutes. The precipitate was then removed by suction filtration and washed on the filter with glacial acetic acid followed by ice-cold ethyl ether. The product, 8-hydroxypsoralen, weighed 115 mg, that is, 74% of theory.
(B) Methylation of 8-Hydroxypsoralen: 115 mg of 8-hydroxypsoralen was dissolved in 10 ml absolute methanol, an excess of diazomethane dissolved in ether was added and the mixture allowed to stand at room temperature with occasional stirring for 3 hours. The next day the reaction mixture was reduced in volume to 3 ml by evaporation on the steam bath and the concentrate was held in a refrigerator overnight. The next day, fine needles (80 mg) of 8- methoxypsoralen were filtered from the solution. The compound had a MP of 145 to 146°C and was obtained in a yield of 65% of theory.
There is also a wholly synthetic route to Methoxsalen as outlined by Kleeman and Engel.

brand name

8-Mop (Valeant); Oxsoralen (Valeant); Uvadex (Therakos).

Therapeutic Function

Dermal pigmentation enhancer

General Description

Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation.

Air & Water Reactions

Sensitive to light and air. Insoluble in water.

Reactivity Profile

8-Methoxypsoralen is incompatible with strong oxidizing agents.

Fire Hazard

Flash point data for 8-Methoxypsoralen are not available; however, 8-Methoxypsoralen is probably combustible.

Contact allergens

This fur(an)ocoumarin is an phototoxic compound that causes phototoxic dermatitis. Many plants of the Apiaceae–Umbelliferae and most of the Rutaceae family contain 5-methoxypsoralen and 8-methoxypsoralen. Their spectra is in the UVA range (300–360 nm). It is used in combination with UVA to treat various skin disorders such as psoriasis.

Safety Profile

Confirmed carcinogen. Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. A drug used to treat slun diseases.

Environmental Fate

The industrial use of 8-MOP results in its release into the environment through multiple pathways, and its existence as a natural substance in plants further expands exposure to the environment. Airborne 8-MOP will exist in the vapor and particulate phases, and will be degraded in air by reaction with photochemically produced hydroxyl radicals, with an estimated half-life of approximately 1.2 h, it may also be subject to direct photolysis by sunlight. Particulate 8-MOP will be removed from the atmosphere by wet or dry deposition. If released into the soil, it is expected to have high mobility and is not expected to volatilize. 8-MOP does not biodegrade. In aqueous environments, 8-MOP is not expected to hydrolyze, it will, however, adsorb to suspended solids and sediment. Due to 8-MOP’Ks resistance to degradation by many routes, it is expected to remain in the environment for a prolonged period, and as such will also be subject to long-range transport. 8-MOP has an estimated bioconcentration factor (BCF) of 9, meaning that bioconcentration and bioaccumulation are low in aquatic organisms.

Purification Methods

Purify xanthotoxin by recrystallisation from *C6H6/pet ether (b 60-80o) to give silky needles, or from EtOH/Et2O to give rhombic prisms or from hot H2O to give needles. It is soluble in aqueous alkali due to ring opening of the cyclic lactone but recyclises upon acidification. It has UV max in EtOH at 219, 249 and 300nm (log  4.32, 4.35 and 4.06) and 1H NMR in CDCl3 with at 7.76 (d, 1H, J 10 Hz), 7.71 (d, 1H, J 2.5 Hz), 7.38 (s, 1H), 6.84 (d, 1H, J 2.5 Hz), 6.39 (d, 1H, J 10 Hz) and 4.28 (s, 3H)ppm. [Nore & Honkanen J Heterocycl Chem 17 985 1980.] It is a DNA intercalator, is used in the treatment of dermal diseases, and is a human carcinogen [Tessman et al. Biochemistry 24 1669 1985.] [Beilstein 19 I 711, 19/6 V 15.]

Toxicity evaluation

The toxic effects of psoralens almost never occur without exposure to UV light. These are photosensitizing materials that exert their primary effect on the skin. 8-MOP, when activated by long-wavelength UV light in the range of 320–400 nm, is strongly erythemogenic, melanogenic, and cytotoxic in the epidermis. The mechanisms of action of 8-MOP in inducing repigmentation of vitiliginous skin have not been established. Repigmentation depends on the presence of functioning melanocytes and UV light. 8-MOP may activate the functional and dihydroxyphenylalanine-positive melanocytes present in vitiliginous skin. An increase in the activity of tyrosinase, the enzyme that catalyzes the conversion of tyrosine to dihydroxyphenylalanine (a precursor of melanin), has been shown in melanin-producing cells exposed in vitro to trioxsalen and UVA light. In addition, binding of photoactivated psoralens (in triplet states) to pyrimidine bases of nucleic acids, with subsequent inhibitions of DNA synthesis, cell division, and epidermal turnover, has been demonstrated. Following photoactivation, 8-MOP forms covalent bonds with DNA to produce monofunctional (addition to a single strand of DNA) and bifunctional adducts (cross-linking to both strands of DNA). Reactions with other proteins also occur. Psoralens may also increase melanin formation by producing an inflammatory reaction in the skin. Other mechanisms of increased pigmentation may include an increase in the number of functional melanocytes (and possibly activation of dormant melanocytes); enhancement of melanin granule synthesis; stimulation of the movement of melanocytes up hair follicles resulting in melanocytic repopulation of the epidermis; and/or hypertrophy of melanocytes and increased arborization of their dendrites. Since psoriasis is a hyperproliferative disorder and other agents effective in the treatment of psoriasis are known to inhibit DNA synthesis, the therapeutic effect of 8-MOP in the treatment of psoriasis probably involves binding to DNA and inhibition of DNA synthesis resulting in decreased cell proliferation; other vascular, leukocyte, or cell regulatory mechanisms may be involved. It has been suggested that at low drug load, 8-MOP binds to DNA as an intercalator, whereas at higher ratios of 8-MOP to DNA, it binds to the outside of DNA, probably in the minor groove and causes some compaction in DNA. Protective eyewear is used to prevent irreversible binding of 8-MOP to proteins and DNA components of the lens. The central hypothesis for the reproductive toxicity of 8-MOP is that it produces reproductive effects by disrupting the hypothalamus– pituitary axis, and the alternative hypothesis is that this compound targets gonadal function, resulting in alteration of pregnancy outcome.

8-Methoxypsoralen Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 8-Methoxypsoralen manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
8-Methoxypsoralen 298-81-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Hangzhou Hyper Chemicals Limited
Product
Methoxsalen 298-81-7
Price
US $0.00-0.00/Gram
Min. Order
10Gram
Purity
USP
Supply Ability
2kg
Release date
2024-04-25
Hebei Yanxi Chemical Co., Ltd.
Product
8-Methoxypsoralen 298-81-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-09

298-81-7, 8-MethoxypsoralenRelated Search:

POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE Psoralen p-Anisaldehyde p-Anisidine Methoxyacetic acid m-Anisyl alcohol Anisole (Trifluoromethoxy)benzene XANTHOTOXOL(RG) XANTHOTOXOL Prickly ash extract Xanthiazone 2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE XANTHOSINE Xanthiside Xanthohumol xanthatin HERALENOL

  • 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo(
  • 2-g][1]benzopyran-7-one,9-methoxy-7h-furo[
  • 8-Methoxy-2',3',6,7-furocoumarin
  • 8-methoxy-2’,3’,6,7-furocoumarin
  • 8-Methoxy-4',5',6,7-furocoumarin
  • 8-Methoxy-4',5':6,7-furocoumarin
  • 8-methoxy-4’,5’,6,7-furocoumarin
  • 8-methoxy-4’,5’:6,7-furocoumarin
  • 8-Methoxy-6,7-furanocoumarin
  • 8-Methoxyfuranocoumarin
  • 8-mopcapsules
  • 8-MP
  • 9-methoxy-7h-furo(3,2-g)(1)benzopyran-7-one
  • 9-Methoxy-7H-furo(3,2-g)benzopyran-7-one
  • 9-Methoxy-7H-furo[3,2-g]chromen-7-one
  • Oxypsoralen
  • Proralone-mop
  • Psoralen-mop
  • psoralon-mop
  • Puvalen
  • Puvamet
  • Uvadex
  • Xanthotoxine
  • Xanthoxin
  • AMMOIDIN
  • AKOS 214-64
  • 8-MOP
  • 8-METHOXYPSORALEN
  • 8-METHOXYPSORALENE
  • 9-methoxypsoralen
  • 9-METHOXYFURO[3,2-G][1]BENZOPYRAN-7-ONE
  • 9-methoxyfuro[3,2-g]chromen-7-one
  • Xanthotoxin,Methoxsalen
  • anthotoxin
  • METHOXSALEN
  • ZANTHOTOXIN
  • XANTHOTOXIN
  • TIMTEC-BB SBB005950
  • 8-Methoxy
  • Methoxsalene
  • NSC 45923
  • Vitpso
  • Methoxsalen(8-Methoxypsoralen、Xanthotoxin)
  • Xanthotoxin 〔8-Methoxypsoralen〕
  • Xanthotoxin, 98%, a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450)
  • 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
  • 5-Benzofuranacrylicacid,6-hydroxy-7-methoxy-,δ-lactone
  • 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid gamma-lactone
  • 6-hydroxy-7-methoxy-5-benzofuranacrylicaciddelta-lactone
  • 6-hydroxy-7-methoxy-5-benzofuranacrylicacidelta-lactone
  • 7-Furocoumarin
  • 7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-
  • 7H-Furo[3,2-g][1]benzopyran-7-one,9-methoxy-
  • 8-methoxy-(furano-3’.2’:6.7-coumarin)
  • 8-Methoxy-[furano-3'.2':6.7-coumarin]
  • 8-methoxy[furano-3’,2’:6,7-coumarin]
  • Ammodin
  • geroxalen