ChemicalBook > CAS DataBase List > 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

Product Name
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
CAS No.
42895-58-9
Chemical Name
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Synonyms
AP 10;14-dehydro Andrographolide;Andrographolide Impurity 1;14-deoxy11,12 deoxyandrographolide;14-Deoxy-11,12-didehydroandrographol;Deoxy 11,14-didehydroandrographolide;14-Deoxy-11,14-didehydroandrographolide;11,12-Didehydro-14-deoxyandrographolide;14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;Deoxy-11,12-Didehydroandrographolide, 14-
CBNumber
CB6735337
Molecular Formula
C20H28O4
Formula Weight
332.43
MOL File
42895-58-9.mol
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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Property

Melting point:
204-205℃
Boiling point:
519.6±50.0 °C(Predicted)
Density 
1.17
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
pka
14.80±0.70(Predicted)
form 
Solid
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89631
Product name
14-Deoxy-11,12-didehydroandrographolide
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$574
Updated
2024/03/01
Sigma-Aldrich
Product number
55549
Product name
14-Deoxy-11,12-didehydroandrographolide
Purity
analytical standard
Packaging
5mg
Price
$426
Updated
2024/03/01
Cayman Chemical
Product number
11670
Product name
14-deoxy-11,12-didehydro Andrographolide
Purity
≥98%
Packaging
500μg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
11670
Product name
14-deoxy-11,12-didehydro Andrographolide
Purity
≥98%
Packaging
1mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
11670
Product name
14-deoxy-11,12-didehydro Andrographolide
Purity
≥98%
Packaging
5mg
Price
$263
Updated
2024/03/01
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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Chemical Properties,Usage,Production

Description

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.

Uses

14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

Definition

ChEBI: 14-Deoxy-11,12-didehydroandrographolide is a diterpene lactone. It has a role as a metabolite.

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Suppliers

China 105 Germany 1 India 2 United Kingdom 1 United States 13 Global 122
MedChemexpress LLC
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View Lastest Price from 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE manufacturers

Dideu Industries Group Limited
Product
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 42895-58-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-21
Shaanxi Dideu Medichem Co. Ltd
Product
14-Deoxy-11,12-didehydroandrographolide 42895-58-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
800 tons
Release date
2020-05-01
Career Henan Chemical Co
Product
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 42895-58-9
Price
US $8.00/KG
Min. Order
1KG
Purity
＞98% HPLC
Supply Ability
20 tons
Release date
2020-02-17

42895-58-9, 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDERelated Search:

β-Elemonic Acid Carboxyatractyloside DARUTOSIDE dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate 10-Deacetylbaccatin III DARUTIGENOL 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one 11-Hydroxy-sugiol ANDROGRAPHOLIDE, DEOXY- Dehydroandrographolide Andrographis Paniculata PE 14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE DEHYDROANDROGRAPHOLIDESUCCINATE Andrographolide AKOS NCG1-0062 3-[2-(6-HYDROXY-5-HYDROXYMETHYL-5,8A-DIMETHYL-2-METHYLENE-DECAHYDRO-NAPHTHALEN-1-YL)-VINYL]-5H-FURAN-2-ONE 4-[1-(3-CARBOXYLATOPROPANOYLOXYMETHYL)-1,4A-DIMETHYL-6-METHYLIDENE-5-[2-(2-OXO-5H-FURAN-3-YL)ETHENYL]DECALIN-2-YL]OXY-4-OXO-BUTANOATE

  • 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
  • 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone
  • ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide
  • 11,12-Didehydro-14-deoxyandrographolide
  • 14-Deoxy-11,14-didehydroandrographolide
  • AP 10
  • Deoxy-11,12-Didehydroandrographolide, 14-
  • 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
  • 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-6α-hydroxy-5,8aα-dimethyldecahydronaphthalene-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
  • 3-[(E)-2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-(hydroxymethyl)-5,8aα-dimethyl-2-methylenenaphthalen-1-yl]vinyl]furan-2(5H)-one
  • 14-Deoxy-11,12-didehydroandrographol
  • 14-Deoxy-11,12-didehydroandrographolide16,15-olide
  • 3,19-Dihydroxylabda-8(17),11,13-trien-16,15-olide
  • 3-((E)-2-((1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)vinyl)furan-2(5H)-one
  • 14-Deoxy-11,12-didehydroandrographolide?, >98%
  • 2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-
  • 14-dehydro Andrographolide
  • 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP
  • Andrographolide Impurity 1
  • 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2H-furan-5-one
  • 14-deoxy11,12 deoxyandrographolide
  • 14 - deoxy11,12-12 dehydroandrographolide
  • 14-Deoxy 11,14-didehydroandrographolide-RM
  • Deoxy 11,14-didehydroandrographolide
  • 42895-58-9