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VESNARINONE

Product Name
VESNARINONE
CAS No.
81840-15-5
Chemical Name
VESNARINONE
Synonyms
Arkin;CS-2139;0PC-8212;OPC 8212;VESNARINONE;Piteranometozine;Vesnarinone(OPC8212);VESNARINONE USP/EP/BP;OPC8212;OPC 8212;OPC-8212;6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
CBNumber
CB6750484
Molecular Formula
C22H25N3O4
Formula Weight
395.45
MOL File
81840-15-5.mol
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VESNARINONE Property

Melting point:
238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
Boiling point:
519.41°C (rough estimate)
Density 
1.2414 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM)
form 
A crystalline solid
pka
2.86(at 25℃)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23489
Product name
Vesnarinone
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23489
Product name
Vesnarinone
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23489
Product name
Vesnarinone
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
23489
Product name
Vesnarinone
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
ChemScene
Product number
CS-5387
Product name
Vesnarinone
Purity
96.06%
Packaging
100mg
Price
$750
Updated
2021/12/16
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VESNARINONE Chemical Properties,Usage,Production

Description

Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.

Description

Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.

Originator

Otsuka (Japan)

Uses

Cardiotonic.

Definition

ChEBI: Arkin (TN) is an organic molecular entity.

brand name

Arkin (Otsuka America);Arkin-Z.

VESNARINONE Preparation Products And Raw materials

Raw materials

4-Methylanisole 3,4-DIHYDROQUINOLIN-2(1H)-ONE Piperazine Formamide

Preparation Products

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VESNARINONE Suppliers

Canada 1 China 51 Europe 2 Germany 1 United Kingdom 3 United States 14 Global 72
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
UK GREEN SCIENTIFIC CO.,LIMITED
Tel
--
Fax
--
Email
sales@gs-chem.com
Country
United Kingdom
ProdList
6098
Advantage
47

81840-15-5, VESNARINONERelated Search:

MK-8931 DOBUTAMINE Pimobendan Olprinone Losartan potassium (4-HYDROXY-PHENYL)-PIPERAZIN-1-YL-METHANONE ETHAMIVAN 1-(4-METHOXYBENZOYL)-PIPERAZINE VESNARINONE 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 4-(4-BENZYLPIPERAZINO)ANILINE (3-METHOXY-PHENYL)-PIPERAZIN-1-YL-METHANONE 2-METHYL-4-(4-METHYLPIPERAZIN-1-YL)ANILINE 1-(3-METHOXYBENZYL)PIPERAZINE 1-(4-METHOXYBENZYL)PIPERAZINE 1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE

  • VESNARINONE
  • Arkin
  • Piteranometozine
  • OPC 8212
  • 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
  • 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-
  • 0PC-8212
  • 3，4-Dihydro-6-[4-(3，4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone
  • Vesnarinone(OPC8212)
  • OPC8212;OPC 8212;OPC-8212
  • CS-2139
  • 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
  • VESNARINONE USP/EP/BP
  • OPC8212,phosphodiesterase 3,Inhibitor,OSC5,OPC 8212,oral activity,OSC4,OSC3,positive inotropic activity,Vesnarinone,heart failure,inhibit,Phosphodiesterase (PDE)
  • 6-(4-(3,4-Dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one
  • 81840-15-5