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Pyridoxal 5'-phosphate monohydrate

Product Name
Pyridoxal 5'-phosphate monohydrate
CAS No.
41468-25-1
Chemical Name
Pyridoxal 5'-phosphate monohydrate
Synonyms
PLP;PYRIDOXAL 5-PHOSPHATE MONOHYDRATE;5-Phosphate Monohydrate;PYRIDOXAL PHOSPHATE MONOHYDRATE;Pyridoxal 5-phosphate monohydrate(PLP);(4-ForMyl-5-hydroxy-6-Methylpyridin-3-yl)Methyl dihydrogen phosphate hydrate;Plp1;ACR1;B116;AOEB116
CBNumber
CB6757175
Molecular Formula
C8H12NO7P
Formula Weight
265.16
MOL File
41468-25-1.mol
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Pyridoxal 5'-phosphate monohydrate Property

Melting point:
140-143 °C(lit.)
storage temp. 
2-8°C
solubility 
Acetonitrile (Slightly), DMSO (Slightly)
form 
Crystalline Powder
color 
Pale yellow
Water Solubility 
5 g/L (20 ºC)
Sensitive 
Light Sensitive
Merck 
14,7979
BRN 
234749
Stability:
Air Sensitive, Moisture Sensitive
InChI
InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
InChIKey
CEEQUQSGVRRXQI-UHFFFAOYSA-N
SMILES
C1(COP(=O)(O)O)=CN=C(C)C(O)=C1C=O.O
CAS DataBase Reference
41468-25-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
2
RTECS 
UV1208000
F 
8-10-23
TSCA 
Yes
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
82870
Product name
Pyridoxal 5′-phosphate monohydrate
Purity
≥97.0% (NT)
Packaging
1g
Price
$71.3
Updated
2024/03/01
Sigma-Aldrich
Product number
82870
Product name
Pyridoxal 5′-phosphate monohydrate
Purity
≥97.0% (NT)
Packaging
5g
Price
$248
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB2501870
Product name
Anti-PDXP (C-terminal) antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μG
Price
$568
Updated
2024/03/01
Sigma-Aldrich
Product number
SRP6075
Product name
PRDX 5 human
Purity
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Packaging
100μG
Price
$483
Updated
2023/06/20
TCI Chemical
Product number
C0377
Product name
Pyridoxal 5-Phosphate Monohydrate
Purity
>98.0%(HPLC)
Packaging
1g
Price
$43
Updated
2024/03/01
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Pyridoxal 5'-phosphate monohydrate Chemical Properties,Usage,Production

Chemical Properties

Pyridoxal Phosphate Hydrate occurs as a pale yellow-white to light yellow crystalline powder.
It is slightly soluble in water, and practically insoluble in ethanol (99.5).
It dissolves in dilute hydrochloric acid and in sodium hydroxide TS.
The pH of a solution prepared by dissolving 0.1 g of Pyridoxal Phosphate Hydrate in 200 mL of water is between 3.0 and 3.5.
Pyridoxal Phosphate Hydrate is colored to light red by light.

Uses

Pyridoxal 5-phosphate (PLP) (active form of Vitamin B6) is an enzyme prosthetic group that acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into GABA; of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

Application

Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.
Pyridoxal 5′-phosphate monohydrate has been used:
as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
as a dietary supplement to study its effects on the lethal phenotype of mutant flies.

Definition

ChEBI: Pyridoxal 5-phosphate monohydrate is a pyridinecarbaldehyde.

Biosynthesis

Two distinct pathways for Pyridoxal 5′-phosphate (PLP) biosynthesis are known. 1.The 'DXP dependent' pathway is found in Escherichia coli and a few members of the γ subdivision of proteobacteria and has been extensively characterized. In this pathway deoxyxylulose 5-phosphate (DXP) is condensed with 3-hydroxy-1-aminoacetone phosphate to give PNP. PNP is oxidized to PLP by PdxH. The DXP dependent pathway is not widely distributed and is surprisingly complex requiring seven enzymes (GapB, PdxB, PdxF (SerC), PdxA, DXS, PdxJ and PdxH). This pathway was the first discovered and it has been extensively reviewed. 2. The second pathway uses Pdx1 and Pdx2 to catalyze the condensation of d-ribose 5-phosphate (R5P), glutamine and glyceraldehyde 3-phosphate to form PLP. The mechanistic and structural characterization of both pathways is at an advanced stage.

General Description

Pyridoxal 5'-phosphate (PLP, vitamin B6) is an essential cofactor in all living systems. It is one of the most versatile cofactors and participates in transamination, decarboxylation, racemization, Cα-Cβ cleavage and α-β elimination reactions. PLP plays an important role in amino acid and carbohydrate metabolism and has been implicated in singlet oxygen resistance. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. By inhibiting AGE formation and working as a coenzyme in chemical reactions, pyridoxal 5’-phosphate can support healthy nerve, eye, cardiovascular and kidney function.

Biological Activity

Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

Pyridoxal 5'-phosphate monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

DL-Tryptophan
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View Lastest Price from Pyridoxal 5'-phosphate monohydrate manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Pyridoxal 5'-phosphate monohydrate 41468-25-1
Price
US $318.00/Kg/Bag
Min. Order
1KG
Purity
98%
Supply Ability
1T
Release date
2021-06-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pyridoxal 5'-phosphate monohydrate 41468-25-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%~102.0%
Supply Ability
1000kg/month
Release date
2021-06-23
airuikechemical co., ltd.
Product
pyridoxal 5′-phosphate 41468-25-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08

41468-25-1, Pyridoxal 5'-phosphate monohydrateRelated Search:

Bensulfuron methyl AMPHISOL A Methylparaben DICALCIUM PHOSPHATE DIHYDRATE Tylosin phosphate CHLOROPHOSPHONAZO III Pyridoxal 5’-Phosphate pyridoxal Thiophanate-methyl Zinc phosphate Methyl acetate MELIBIOSE Triethyl phosphate Kresoxim-methyl Alkaline Phosphatase Methyl acrylate Trisodium phosphate Pyridoxal phosphate

  • 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehydemonohydr
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  • Pyridoxal 5′-phosphate, monohydrate, 98%+
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