2-BROMO-4-PHENYLPYRIDINE

Uses

Product Name: 2-BROMO-4-PHENYLPYRIDINE
CAS No.: 54151-74-5
Chemical Name: 2-BROMO-4-PHENYLPYRIDINE
Synonyms: Methyl 2-bromo-4-phenylpyridine;4-Phenyl-2-bromopyridine;2-BROMO-4-PHENYLPYRIDINE;2-bromo-4-phenyl-pyridin;2-bromine-4-phenylpyridine;Pyridine, 2-bromo-4-phenyl-;2-Bromo-4-phenylpyridine 97+%;(2-Bromo-pyridin-4-yl)benzene
CBNumber: CB6769945
Molecular Formula: C11H8BrN
Formula Weight: 234.09
MOL File: 54151-74-5.mol

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2-BROMO-4-PHENYLPYRIDINE Property

Melting point:: 65-66 °C(Solv: ligroine (8032-32-4))
Boiling point:: 311.7±22.0 °C(Predicted)
Density: 1.426±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 0.96±0.10(Predicted)
form: powder
color: Yellow
InChI: InChI=1S/C11H8BrN/c12-11-8-10(6-7-13-11)9-4-2-1-3-5-9/h1-8H
InChIKey: KRIILKQTJUOQCJ-UHFFFAOYSA-N
SMILES: C1(Br)=NC=CC(C2=CC=CC=C2)=C1
EPA Substance Registry System: 2-Bromo-4-phenylpyridine (54151-74-5)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB142806
Product name: 2-Bromo-4-phenylpyridine
Packaging: 250mg
Price: $67.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142806
Product name: 2-Bromo-4-phenylpyridine
Packaging: 500mg
Price: $115
Updated: 2021/12/16

Apolloscientific

Product number: OR9966
Product name: 2-Bromo-4-phenylpyridine
Purity: 97+%
Packaging: 1g
Price: $131
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-U9
Product name: 2-Bromo-4-phenylpyridine
Packaging: 1g
Price: $144
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142806
Product name: 2-Bromo-4-phenylpyridine
Packaging: 1g
Price: $201
Updated: 2021/12/16

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2-BROMO-4-PHENYLPYRIDINE Chemical Properties,Usage,Production

Uses

2-Bromo-4-phenylpyridine is used as an intermediate in organic synthesis and pharmaceuticals.

Synthesis

939-23-1

54151-74-5

The general procedure for the synthesis of 2-bromo-4-phenylpyridine from 4-phenylpyridine was as follows: dimethylaminoethanol (DMAE, 1.50 mL, 15.0 mmol) was dissolved in hexane (20.0 mL) and stirred under cooling in an ice bath. Under the same cooling conditions, n-butyllithium (2.5 mol/L hexane solution, 12.0 mL, 30.0 mmol) was slowly added dropwise, followed by stirring the reaction mixture for 30 minutes. Keeping the ice bath cool, a hexane solution (30.0 mL) of 4-phenylpyridine (776 mg, 5.00 mmol) was slowly added and stirring was continued for 1 h under these conditions. The reaction system was cooled to -78°C, a hexane solution (15.0 mL) of carbon tetrafluoride (6.30 g, 18.0 mmol) was slowly added dropwise and stirred for 50 minutes. Upon completion of the reaction, deionized water was added under cooling in an ice bath to quench the reaction, followed by extraction with ethyl acetate (100 mL x 2). The organic layers were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography using ethyl acetate/hexane (1:4, v/v) as eluent to afford the target product 2-bromo-4-phenylpyridine (645 mg, 55.1% yield).

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 5, p. 2028 - 2029
[2] Patent: TW2016/39840, 2016, A. Location in patent: Paragraph 0020; 0040
[3] Patent: WO2007/20888, 2007, A1. Location in patent: Page/Page column 43
[4] Journal of the American Chemical Society, 1956, vol. 78, p. 5842

2-BROMO-4-PHENYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4-PHENYLPYRIDINE Suppliers

Canada 1 China 72 Germany 1 India 1 United Kingdom 2 United States 5 Global 82

Synthonix Inc

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Precursor Chemicals, Inc.

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View Lastest Price from 2-BROMO-4-PHENYLPYRIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-BROMO-4-PHENYLPYRIDINE 54151-74-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

54151-74-5, 2-BROMO-4-PHENYLPYRIDINERelated Search:

3-BROMO-4-PHENYLPYRIDINE 2-BROMO-5-PHENYLPYRIDINE 2-BROMO-3-PHENYLPYRIDINE 2-BROMO-6-PHENYLPYRIDINE 4-BROMO-3-PHENYLPYRIDINE 3-BROMO-5-PHENYLPYRIDINE 4-Bromo-2-phenylpyridine 3-AMINO-6-BROMO-2-PHENYLPYRIDINE 2-AMINO-3-BROMO-5-PHENYLPYRIDINE 5-BROMO-2-PHENYLPYRIDINE 3-BROMO-N-PHENYLPYRIDINE-4-CARBOXAMIDE 3-BROMO-2-PHENYLPYRIDINE 2-BROMO-4-PHENYLPYRIDINE 2-BROMO-4-(3-METHOXYPHENYL) PYRIDINE 2-Bromo-4-methylpyridine 2-BROMO-4-(3-(TRIFLUOROMETHYL)PHENYL) PYRIDINE

Pyridine, 2-bromo-4-phenyl-

(2-Bromo-pyridin-4-yl)benzene

2-bromo-4-phenyl-pyridin

2-BROMO-4-PHENYLPYRIDINE

4-Phenyl-2-bromopyridine

Methyl 2-bromo-4-phenylpyridine

2-Bromo-4-phenylpyridine 97+%

2-bromine-4-phenylpyridine

54151-74-5