Naphthoic acid derivative Pharmacological effects Pharmacokinetics Adapalene acid drug safety compared with other topical Vitamin A Uses
ChemicalBook > CAS DataBase List > Adapalene

Adapalene

Naphthoic acid derivative Pharmacological effects Pharmacokinetics Adapalene acid drug safety compared with other topical Vitamin A Uses
Product Name
Adapalene
CAS No.
106685-40-9
Chemical Name
Adapalene
Synonyms
Adapalen;Differin;6-(3-(AdaMantan-1-yl)-4-Methoxyphenyl)-2-naphthoic acid;6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid;6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHALENE CARBOXYLIC ACID;ADPL;CD-271;Differi;p75(NTR);ADAPALENE
CBNumber
CB6771245
Molecular Formula
C28H28O3
Formula Weight
412.52
MOL File
106685-40-9.mol
More
Less

Adapalene Property

Melting point:
319-3220C
Boiling point:
606.3±55.0 °C(Predicted)
Density 
1.233±0.06 g/cm3(Predicted)
RTECS 
QJ1987000
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
White solid
pka
4.2(at 25℃)
color 
white to off-white
Merck 
14,150
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months
InChI
InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
InChIKey
LZCDAPDGXCYOEH-UHFFFAOYSA-N
SMILES
C1=C2C(C=C(C3=CC=C(OC)C(C45CC6CC(CC(C6)C4)C5)=C3)C=C2)=CC=C1C(O)=O
CAS DataBase Reference
106685-40-9(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
nwg
HS Code 
2918992090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
114825-M
Product name
Adapalene
Packaging
25mg
Price
$155
Updated
2024/03/01
Sigma-Aldrich
Product number
1011709
Product name
Adapalene
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
A2549
Product name
Adapalene
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$364
Updated
2024/03/01
TCI Chemical
Product number
A2549
Product name
Adapalene
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$104
Updated
2024/03/01
Alfa Aesar
Product number
J67025
Product name
Adapalene
Packaging
25mg
Price
$117
Updated
2021/12/16
More
Less

Adapalene Chemical Properties,Usage,Production

Naphthoic acid derivative

Adapalene, a new class of drugs Naphthoic acid derivatives, was developed by France Galdeama Laboratories Company. It first entered into market in June 1996, under the trade name "Differin", mainly used for relieving inflammatory skin lesions, adjusting differentiation of hair follicles, gland epithelial cells, and also acne treatment.

Pharmacological effects

Adapalene is a retinoid compounds, and is proven to have anti-inflammatory properties in both in vivo and in vitro models of inflammation. It has stable chemical structure, and is not easily to break down in the air and the light. It shares the same mode of action with retinoic acid, bounding to specific retinoic acid nuclear receptors except that adapalene doesn’t bound to the cytoplasmic protein binding receptor. It has been proven to treat acne and affect acne vulgaris and differentiation in skin drug tests established by mouse animal model. Its mechanism of action is reducing the formation of micro-acne through leading the normal differentiation of hair follicle cells. In the standard anti-inflammatory assay both in vivo and in vitro, adapalene has a better effect than retinoic acid. It can inhibit the chemotaxis reaction of human polymorphonuclear leukocytes and also inhibit the metabolism of polymorphonuclear cell through inhibition the formation of anti-inflammatory mediators via oxidation reaction of arachidonic acid, thus relieving inflammatory response by the cell-mediated response. It is useful in the treatment of routine skin with acne, pimples and pustules as the main performance. It can also be used for the treatment of the acne presented in face, chest and back.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Pharmacokinetics

The transdermal absorption rate of adapalene is very low. In clinical trials, the adapalene level of skin acne areas subject to long-term treatment is undetectable. Appling C14 labeled adapalene for rats (intravenous, intraperitoneal injection, oral and dermal medication), rabbits (intravenous oral and dermal administration), respectively, clarified the distribution of radioactivity among various tissues. Also, liver, spleen adrenal and ovarian have the highest level. Adapalene is mainly metabolized through demethylation, hydroxylation and binding reactions of oxygen 1 and metabolism in vivo and mainly excreted through bile.
[Interaction] No interaction between the product and other skin drugs has been reported. But we should not use other retinoids or other drugs with similar mechanism of action. Adapalene has stable chemical structure, and is not easily to break down in the air and sunlight. A wide range of animal and human studies found no phototoxicity and photosensitivity. However, it is not clear whether it is safe to take it when animal and humans are subject to repeated exposure to sunlight or ultraviolet. Avoid excessive sunshine and UV radiation when use this product. Adapalene has a very low level of transdermal absorption, making it impossible to interact with the systematic medication drugs. No evidence was found that the effect of birth control pills, antibiotics and other oral medications are affected by the using Duff Man for treating skin disease.
Duff Man may have a slight local stimulation. Being treated together with the peeling agent, agent or contraction irritating substances can cause additional irritation. Therefore, use other skin medication early in the morning such as erythromycin (concentrations ≤4%), clindamycin phosphate (1%) aqueous solution or benzoyl peroxide gel (concentration ≤10%); Use Duff Man gel at night so that you can avoid drug co-degradation or accumulation of stimulation effect.
[Adverse reactions] During the first 2-4 weeks of treatment, the most common adverse reactions are erythema, dryness, scaling, itching, burning or tingling. The extent is mostly mild to moderate. Less frequent adverse reactions include: sunburn, skin irritation, burning and stinging skin discomfort. Rarely adverse reactions include: redness of acne, dermatitis and contact dermatitis, eye swelling, conjunctivitis, redness, itching, skin discoloration, rashes and eczema. Reduce the amount of drugs applied or totally withdrawal when serious adverse reactions happen.

Adapalene acid drug safety compared with other topical Vitamin A

The effect of traditional topical Vitamin A acid drugs (RA) on the treatment of acne vulgaris is indeed very good, but the irritating side effects limit its use. RA causes local irritation because of its unstable structure and poor receptor selectivity caused by series of weak divalent bond chains in its molecular structure. Studies have shown that RA can be degraded by a number of factors: exposure to sunlight within 24 h, 60.0%~80.0% of baseline concentration RA degradation, and if use an oxidizing agent such as benzoyl peroxide the same time when apply RA, 80% of RA would be degraded within 4 h, and all RA disappear within 24 h. In order to find a more stable molecule with similar effect as RA but much smaller side effect, people developed a naphthoic acid derivative-adapalene. Adapalene has small irritation effect due to: 1. Molecularly stable: The unstable divalent bond chains in RA are replaced by the aromatic ring of naphthoic acid, making it stable in the light and oxidants without degradation even in 72 h. 2. Highly selective receptor binding: after entering the cell, RA first bound to cytoplasmic vitamin A acid bound protein (CRABP), and has no selectivity when binds to nuclear receptor RARα, β, γ. Adapalene does not bind CRABP, but selectively binds to specific amino acids sequences of the binding site in nuclear receptor RAR-β and RAR-γ receptor, then binds to RXR, further binds to specific DNA sites, regulating transcription machinery, protein synthesis, and cell proliferation and differentiation. Therefore, it is highly specific and has a small side effect. 3. Low cellular toxicity: Study found that effects of different vitamin A acid on keratinocyte cell cytotoxicity are also different. Adapalene molecule is neutral, has low cytotoxicity to keratinocytes compared with the long-chain organic acids, Vitamin A acid. 4. Adapalene has a clear anti-inflammatory effect. However, this kind of effect for other Vitamin A acid is not still clear.
In short, adapalene, a third generation vitamin A drugs, not only have a stronger effect on regulation of epidermal cell differentiation, inhibit proliferation of hair follicle keratinocytes and keratinocytes, inhibition sebaceous cell proliferation, dissolved angle plug acne, etc than all-trans vitamin A acid drugs, but also has a strong anti-inflammatory effect. Because of its unique stability, its efficacy and tolerability is much higher than other Vitamin A acid drugs.

Uses

Retinoic acid analogs. Adapalene is an agonist of RARβ, and RARγ receptor. Adapalene inhibits cell proliferation and inducing apoptosis in colorectal cancer cells in vitro. Adapalene gel is an effective medication for treatment of acne.

Description

Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively). It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs). It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants. It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema. Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner. Formulations containing adapalene have been used in the treatment of acne vulgaris.

Chemical Properties

White Crystalline Solid

Originator

Adaferin ,Laboratoires Galderma ,France

Uses

Adapalene has been used as a retinoic acid receptor (RAR) agonist to study its effects on inhibiting transcription of hepatitis B virus in covalently closed circular DNA (cccDNA). It has also been used as a component to culture mixed lymphocyte reactions (MLR) to study its effects on isolated macrophages.

Uses

Retinoid selective for retinoic acid receptor (RAR) subtypes ?and . Antiacne

Uses

Retinoid selective for retinoic acid receptor (RAR) subtypes β and γ. Antiacne.

Uses

anesthetic

Uses

inhibits serotonin and noradrenaline reuptake antidepressant antimigraine therapeutic

Uses

Acnetreatment

Definition

ChEBI: A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.

Indications

Adapalene (Differin) is a polyaromatic retinoidlike compound that binds to specific retinoic acid nuclear receptors and is thought to normalize the differentiation of keratinocytes in the sebaceous acroinfundibulum. Adapelene is indicated for topical treatment of acne. Minor local irritation is a common, usually tolerable side effect. In contrast to other drugs of the retinoid group, adapalene has not been shown to be teratogenic in rodents. However, since adequate human studies are lacking, its use in pregnant women should be discouraged until further information is available.

Manufacturing Process

Preparation of 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid consist of 4 steps.
1. 2-(1-Adamantyl)-4-bromophenol.
34.6 g (200 mmol) of p-bromophenol and 30.4 g (200 mmol) of 1- adamantanol are dissolved in 100 ml of dichloromethane. To the resulting solution there are slowly added 10 ml of concentrated sulfuric acid. The mixture is stirred for 8 hours at ambient temperature, poured into water, neutralized with sodium bicarbonate, extracted with methylehe chloride, dried and evaporated. After recrystallization in isooctane 52.8 g of the expected product are obtained. Yield - 86%. MP: 140°-141°C. 2. 2-(1-Adamantyl)-4-bromoanisole.
To suspension of sodium hydride (80% in oil, 4.32 g, 144 mmol) in 50 ml of THF, there are slowly added while maintaining the temperature at 20°C, 36.8 g (120 mmol) of 2-(1-adamantyl)-4-bromophenol. The mixture is stirred for 1 hour at ambient temperature at which point 9 ml of methyl iodide are added. The mixture is then stirred for 2 hours at 20°C, poured into water, extracted with ether, dried and evaporated. The product is purified by passage through a silica column (10x30), eluting with a mixture of hexane (90%) and dichloromethane (10%). On evaporation, 26.2 g of a white solid are obtained. Yield - 68%. MP: 138°-139°C.
3. Methyl ester of 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid.
To a suspension of magnesium (1.64 g, 67.5 mmol in 30 ml of THF, there is added a solution of 1.4 g (4.5 mmol) of 2-(1-adamantyl)-4-bromoanisole and 0.39 ml of dibromoethane in 10 ml of THF. The mixture is stirred until the reaction is initiated and then there is slowly added a solution of (40.8 mmol) of 2-(1-adamantyl)-4-bromoanisole in 90 ml of THF. The mixture is refluxed for 2 hours, and then cooled to 20°C. After that 6.2 g (45 mmol) of anhydrous ZnCl2 are added. The mixture is stirred for 1 hour at 20°C at which point 7.95 g (30 mmol) of methyl 6-bromo-2-naphthoate are added followed by addition of 300 g of NiCl2/1,2-(diphenylphosphino)ethane-complex as the catalyst. The mixture is stirred again for 2 hours at 20°C, poured into water, extracted with CH2Cl2 dried and evaporated. The product is isolated by column chromatography, eluting with a mixture of heptane (70%) and dichloromethane (30%) and then recrystallized in ethyl acetate. 12.2 g of the expected product are obtained. Yield - 78%. MP: 222°-223°C.
4. 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid.
10.5 g of the ester obtained above (step 3) are treated with a solution of soda in methanol (200 ml, 4.2 N). The mixture is heated at reflux for 48 hours. The solvents are evaporated and the resulting residue is taken up in water and acidified with concentrated HCl. The solid is filtered and dried under vacuum over phosphoric anhydride. The resulting white solid is recrystallized in a mixture of THF and ethyl acetate. 8.2 g of expected product are obtained. Yield - 81%. MP: 325°-327°C.

brand name

Differin (Galderma).

Therapeutic Function

Antiacne

General Description

Adapalene is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.

Biological Activity

Retinoic acid analog that is a RAR β and RAR γ agonist (AC 50 values are 2.2, 9.3, 22 and > 1000 nM for RAR β , RAR γ , RAR α and RXR α receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro . Displays comedolytic activity.

Biochem/physiol Actions

Retinoic acid analogue that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Displays comedolytic activity. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.

storage

Store at +4°C

Structure and conformation

Retinoid-like compound that binds to retinoic acid nuclear receptors, but not to cytoplasmic receptor proteins.

References

1) Michel et al. (1998), Pharmacology of Adapalene; Br. J. Dermatol., 139 Suppl. 52 3 2) Ocker et al. (2003), The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells on vitro; Int. J. Cancer, 107 453 3) Milikan et al. (2000), Adapalene: an update on newer comparative studies between the various retinoids; Int. J. Dermatol., 39 784 4) Bernard et al. (1993), Adapalene, a new chemical entity with retinoid activity; Skin Pharmacol., 6 61

Adapalene Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Adapalene Suppliers

Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
027-027-59212684 19107121455
Fax
QQ:2188308251
Email
p19107121455@163.com
Country
China
ProdList
1797
Advantage
58
Beijing Chempion Pharm-Tech Co. Ltd.
Tel
18601331139
Fax
QQ:3454155726
Email
BD@chempion.com.cn
Country
China
ProdList
146
Advantage
58
Hubei wei shi reagent group ltd., company
Tel
027-027-59102966 18717199209
Email
2853877583@qq.com
Country
China
ProdList
5764
Advantage
58
Henan yingchuang
Tel
0370-3678455 16650708709
Fax
qq:778660296
Email
hnyingchuang@163.com
Country
China
ProdList
3961
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7583
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Mediking Biopharm Co., Ltd
Tel
010-81769521,89753524,81760121 15901403431
Fax
+86-10-81769652
Email
sales01@mediking.cn
Country
China
ProdList
99
Advantage
68
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17987
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Shanghai Everchem Co., Ltd
Tel
86-29-81325371
Fax
+86-29-81325373
Email
info@everchem.cn
Country
China
ProdList
85
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Syncozymes (Shanghai) Co.,Ltd.
Tel
021-68187180-819 13681683526
Fax
021-68187179
Email
lchen@syncozymes.com
Country
China
ProdList
186
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8033
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1975
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1958
Advantage
55
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Eastbang Pharmaceuticals Technology Co., Ltd.
Tel
+86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax
+86 (20) 39218032
Country
China
ProdList
454
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
Junyu Chemexpress Co., Ltd.
Tel
0731-88036271 13723890100
Fax
0731-88036271
Email
info@csjyyy.com
Country
China
ProdList
47
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9352
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9636
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2071
Advantage
56
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
10015
Advantage
53
More
Less

View Lastest Price from Adapalene manufacturers

Hebei Dangtong Import and export Co LTD
Product
Adapalene 106685-40-9
Price
US $3740.00-3720.00/kilograms
Min. Order
10kilograms
Purity
99%
Supply Ability
100tons
Release date
2023-02-17
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Adapalene 106685-40-9
Price
US $5.00/kg
Min. Order
1kg
Purity
99.92%
Supply Ability
50000tons
Release date
2024-04-26
Shaanxi Dideu Medichem Co. Ltd
Product
Adapalene 106685-40-9
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25

106685-40-9, AdapaleneRelated Search:


  • Adapalen
  • ADAPALENE
  • 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHALENE CARBOXYLIC ACID
  • 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID
  • 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid
  • 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid
  • CD-271
  • Differi
  • Adapalene - CAS 106685-40-9 - Calbiochem
  • Adapalene-13C6
  • Differin
  • 6-[4-Methoxy-3-(adamantan-1-yl)phenyl]-2-naphthalenecarboxylic acid
  • 6-[3-(adaMantan-1-yl)-4-Methoxyphenyl]naphthalene-2-carboxylic acid
  • 6-(3-(AdaMantan-1-yl)-4-Methoxyphenyl)-2-naphthoic acid
  • [1]6-[4-Methoxy-3-(tricyclo[3.3.1.1~3,7~]dec-1-yl)phenyl]naphthalene-2-carboxylic acid
  • p75(NTR)
  • Monoclonal Anti-NGFR antibody produced in mouse
  • ADPL
  • Adapalene (200 mg)
  • 2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-
  • Adapalene, >=99%
  • Adapalene (superfine)
  • Adapalene-d6
  • ADAPALENE-API
  • Adapalone
  • Adapalene for peak identification CRS
  • Adapalene CRS
  • Adapalene &gt
  • Adapalene USP/EP/BP
  • AdapaleneQ: What is Adapalene Q: What is the CAS Number of Adapalene Q: What is the storage condition of Adapalene Q: What are the applications of Adapalene
  • Adapalene (1011709)
  • Ada palin
  • 106685-40-9
  • C28H28O3
  • C28H29O3
  • Pharmaceutical raw materials
  • Adamantane derivatives
  • Antiacne
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • ULTANE
  • Aromatics
  • Adapalen
  • APIs
  • API