5-BROMO-2-METHYLPYRIDIN-3-AMINE
Description Reference- Product Name
- 5-BROMO-2-METHYLPYRIDIN-3-AMINE
- CAS No.
- 914358-73-9
- Chemical Name
- 5-BROMO-2-METHYLPYRIDIN-3-AMINE
- Synonyms
- 3-Amino-5-bromopicoline;3-Amino-5-bromo-2-methylp...;3-Amin-5-bromo-2-methylpyridine;5-bromo-2-methyl-3-Pyridinamine;5-BROMO-2-METHYLPYRIDIN-3-AMINE;2-Methyl-3-amino-5-bromopyridine;3-Amino-5-bromo-2-methylpyridine;5-Bromo-2-Methylpyridine-3-amine;3-pyridinaMine, 5-broMo-2-Methyl;5-BroMo-2-Methyl-pyridin-3-ylaMine
- CBNumber
- CB6818821
- Molecular Formula
- C6H7BrN2
- Formula Weight
- 187.04
- MOL File
- 914358-73-9.mol
5-BROMO-2-METHYLPYRIDIN-3-AMINE Property
- Melting point:
- 108-109℃
- Boiling point:
- 283.5±35.0 °C(Predicted)
- Density
- 1.593±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- crystalline solid
- pka
- 4.53±0.20(Predicted)
- color
- Off-white
- InChI
- InChI=1S/C6H7BrN2/c1-4-6(8)2-5(7)3-9-4/h2-3H,8H2,1H3
- InChIKey
- CBAXYISWNGGXOZ-UHFFFAOYSA-N
- SMILES
- C1(C)=NC=C(Br)C=C1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 3H30-9-42
- Product name
- 3-Amino-5-bromo-2-methylpyridine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 066625
- Product name
- 3-Amino-5-bromo-2-methylpyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J94603
- Product name
- 5-Bromo-2-methylpyridin-3-amine
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA55674
- Product name
- 3-Amino-5-bromo-2-methylpyridine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3H30-9-42
- Product name
- 3-Amino-5-bromo-2-methylpyridine
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
5-BROMO-2-METHYLPYRIDIN-3-AMINE Chemical Properties,Usage,Production
Description
5-Bromo-2-methylpyridin-3-amine is also named as 3-Amino-5-bromo-2-methylpyridine. It can be converted to 5-bromo-2-methyl-3-pyridinol by diazotization with sodium nitrite in aqueous sulfuric acid. 5-Bromo-2-methyl-3-pyridinol can be used to make brominated dihydropyridines, which are substrates for the palladium catalyzed coupling, a process to produce compounds for the treatment of patients with disorders, such as central nervous system disorders.
Reference
G. Dull, J. Munoz, J. Genus, J. Moore, Hydroxybenzoate salts of metanicotine compounds, Patent US20060122239A1
Uses
3-Amino-5-bromo-2-methylpyridine (3ABMP) is a kind of biochemical reagent.
Synthesis
911434-05-4
914358-73-9
The general procedure for the synthesis of 2-methyl-3-amino-5-bromopyridine from 5-bromo-2-methyl-3-nitropyridine was as follows: 5-bromo-2-methyl-3-nitropyridine (13.8 g, 63.9 mmol) was dissolved in industrial methanol (330 mL) at 40 °C, followed by the addition of powdered iron (20 g) in batches to avoid agglomeration. Next, concentrated aqueous hydrochloric acid (5 mL) was added for elution. The resulting dark brown mixture was stirred vigorously under reflux conditions for 2 h. After completion of the reaction, it was cooled to room temperature and filtered through Celite (the filter cake was washed with 1 L of industrial methanol). The filtrate was concentrated under reduced pressure to remove the solvent, and the residue was dissolved in ethyl acetate (200 mL), the organic phase was washed with saturated aqueous sodium bicarbonate (200 mL), and dried with anhydrous magnesium sulfate. Finally, the solvent was removed under reduced pressure to afford the target product 5-bromo-2-methylpyridin-3-amine as an orange solid (10.7 g, 90% yield). The structure of the product was confirmed by 1HNMR (400 MHz, CDCl3, δ): 7.91 (s, 1H), 7.00 (s, 1H), 3.75 (br.s, 2H), 2.25 (s, 3H).
References
[1] Bergmeyer, et al. "Biochemical reagents." Methods of Enzymatic Analysis. Academic Press, 1965. 967-1037.
5-BROMO-2-METHYLPYRIDIN-3-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-2-METHYLPYRIDIN-3-AMINE Suppliers
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View Lastest Price from 5-BROMO-2-METHYLPYRIDIN-3-AMINE manufacturers
- Product
- 5-BROMO-2-METHYLPYRIDIN-3-AMINE 914358-73-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 5-BROMO-2-METHYLPYRIDIN-3-AMINE 914358-73-9
- Price
- US $6.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03
- Product
- 5-bromo-2-methylpyridin-3-amine 914358-73-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2019-12-25