ChemicalBook > CAS DataBase List > 2,4,6-Collidine

2,4,6-Collidine

Product Name
2,4,6-Collidine
CAS No.
108-75-8
Chemical Name
2,4,6-Collidine
Synonyms
2,4,6-TRIMETHYLPYRIDINE;S-COLLIDINE;g-Collidine;2,4,6-Kollidin;246CO;246BD;2,4,6-CoL;SYM COLLIDINE;2,4,6-COLLIDINE;GAMMA-COLLIDINE
CBNumber
CB6852760
Molecular Formula
C8H11N
Formula Weight
121.18
MOL File
108-75-8.mol
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2,4,6-Collidine Property

Melting point:
-43 °C (lit.)
Boiling point:
171-172 °C (lit.)
Density 
0.917 g/mL at 25 °C (lit.)
vapor pressure 
4 hPa (20 °C)
refractive index 
n20/D 1.498(lit.)
Flash point:
135 °F
storage temp. 
Store below +30°C.
solubility 
35g/l
form 
Liquid
pka
7.43(at 25℃)
color 
Clear colorless to yellow
Water Solubility 
35 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,9718
BRN 
107283
Dielectric constant
1.9（20℃）
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
LogP
1.25 at 20℃
CAS DataBase Reference
108-75-8(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,4,6-trimethyl-(108-75-8)
EPA Substance Registry System
2,4,6-Trimethylpyridine (108-75-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
10-20/21/22-36/37/38
Safety Statements 
26-36/37-36
RIDADR 
UN 1992 3/PG 3
WGK Germany 
3
RTECS 
UU0970000
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29333999
Hazardous Substances Data
108-75-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 400 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22267
Product name
2,4,6-Trimethylpyridine
Purity
for synthesis
Packaging
50mL
Price
$53
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22267
Product name
2,4,6-Trimethylpyridine
Purity
for synthesis
Packaging
250ML
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22267
Product name
2,4,6-Trimethylpyridine
Purity
for synthesis
Packaging
1L
Price
$429
Updated
2024/03/01
Sigma-Aldrich
Product number
142387
Product name
2,4,6-Trimethylpyridine
Purity
ReagentPlus , 99%
Packaging
5ml
Price
$29.2
Updated
2024/03/01
Sigma-Aldrich
Product number
142387
Product name
2,4,6-Trimethylpyridine
Purity
ReagentPlus , 99%
Packaging
1l
Price
$832
Updated
2024/03/01
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2,4,6-Collidine Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

2,4,6-Collidine is used as a tissue fixative for electron microscopy. It is useful in dehydrohalogenation reactions and acts as a solvent for the cleavage of hindered esters by anhydrous lithium iodide.

Uses

2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.

Definition

Methyl, ethyl, propyl, and trimethyl homologs of pyridine.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 4184, 1950 DOI: 10.1021/ja01165a097

General Description

2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. Collidine-buffered osmium tetroxide solutions have been prepared by adding osmium tetroxide solution to it. These solutions have been used as fixative for electron microscopic studies.
2,4,6-Trimethylpyridine can undergo oxidation with potassium permanganate to form 2,4,6-pyridinetricarboxylic acid.

Hazard

Toxic.

Flammability and Explosibility

Flammable

Purification Methods

Commercial samples may be grossly impure. Likely contaminants include 3,5-dimethylpyridine, 2,3,6-trimethylpyridine and water. Brown, Johnson and Podall [J Am Chem Soc 76 5556 1954] fractionally distilled 2,4,6-trimethylpyridine under reduced pressure through a 40cm Vigreux column (p 11) and added to 430mL of the distillate slowly, with cooling to 0o, 45g of BF3-diethyl etherate. The mixture was again distilled, and an equal volume of dry *benzene was added to the distillate. Dry HCl was passed into the solution, which was kept cold in an ice-bath, and the hydrochloride was filtered off. It was recrystallised from absolute EtOH (1.5mL/g) to m 286-287o[m 256o(sealed tube), also m 293-294o subliming slowly]. The free base was regenerated by treatment with aqueous NaOH, then extracted with *benzene, dried (MgSO4) and distilled under reduced pressure. Sisler et al. [J Am Chem Soc 75 446 1953] precipitated trimethylpyridine as its phosphate from a solution of the base in MeOH by adding 85% H3PO4, shaking and cooling. The free base was regenerated as above. Garrett and Smythe [J Chem Soc 763 1903] purified the trimethylpyridine via the HgCl2 complex. It is more soluble in cold than hot H2O [the solubility is 20.8% at 6o, 3.5% at 20o, 1.8% at 100o]. Alternatively, purify it by dissolving it in CHCl3, adding solid K2CO3 and Drierite, filtering and fractionally distilling through an 8in helix-packed column. The sulfate has m 205o, and the picrate (from hot H2O) has m 155-156o. [Frank & Meikle J Am Chem Soc 72 4184 1950, Beilstein 20 H 250, 20 I 87, 20 II 164, 20 III/IV 2810, 20/6 V 93.]

2,4,6-Collidine Preparation Products And Raw materials

Raw materials

Acetone Zinc chloride Urea Benzene Phosphorus pentoxide Sulfuric acid Ammonia

Preparation Products

4,6-DIMETHYL-PYRIDINE-2-CARBOXYLIC ACID 2-Cyclopenten-1-one Estrone
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View Lastest Price from 2,4,6-Collidine manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
2,4,6-Collidine 108-75-8
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2,4,6-Collidine 108-75-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
10 TONS/Month
Release date
2021-06-25
Hebei Longbang Technology Co., Ltd
Product
2,4,6-Collidine 108-75-8
Price
US $6.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-04-29

108-75-8, 2,4,6-CollidineRelated Search:

Pyridine sulfur trioxide 4-Methylpyridine Azamethiphos 2-Chloro-5-chloromethylpyridine 2,6-Lutidine trimethylpyridine,MIX-COLLIDINE,collidine(combustibleliquid,n.o.s. Pyrroloquinoline quinone 2,3,5-COLLIDINE,2,3,5-COLLIDINE 2,3,5-TRIMETHYLPYRIDINE,2,3,5-Collidine, 99+%,2,3,5-COLLIDINE 2,3,5-TRIMETHYLPYRIDINE,2,3,5-TRIMETHYLPYRIDINE 2.4.6-TRIMETHYL-3-NITROPYRIDINE HYDROGEN FLUORIDE 2,4,6-COLLIDINE COMPLEX 1-FLUORO-2,4,6-TRIMETHYLPYRIDINIUM TRIFLATE Streptonigrin 2,6-Di-tert-butyl-4-methylpyridine 2,4,6-TRI-TERT-BUTYLPYRIDINE 2,6-DIPHENYL-4-(2,4,6-TRIPHENYL-1-PYRIDINIO)PHENOLATE 2,4,6-TRIMETHYLPYRIDINIUM P-TOLUENESULFONATE 2,4,6-TRIPHENYLPYRIDINE 3-Acetyl-2,4,6-trimethylpyridine

  • 2,4,6-Kollidin
  • 2,4,6-trimethyl-pyridin
  • a,g,a'-Collidine
  • alpha,gamma,alpha’-collidine
  • alpha,gamma,alpha'-Collidine
  • g-Collidine
  • Pyridine,2,4,6-trimethyl-
  • 2 Minus 2-3 Methyl pyridine
  • 2,4,6-Trimethylpyridine puriss. p.a., >=99.0% (GC)
  • 2,4,6-Trimethylpyridine ReagentPlus(R), 99%
  • 2,4,6-Trimethylpyridine Vetec(TM) reagent grade, 98%
  • 2,4,6-Trimethylpyridine, 98.5%
  • TMP 2,4,6-Collidine sym-Collidine s-Collidine
  • 2,4,6-CoL
  • S-COLLIDINE
  • SYM COLLIDINE
  • 246CO
  • 2,4,6-COLLIDINE
  • 2,4,6-TRIMETHYLPYRIDINE
  • GAMMA-COLLIDINE
  • 2,4,6-COLLIDINE, REAGENTPLUS, 99%
  • #nsym.-Collidine
  • 2,4,6-Collidine99%
  • 2,4,6-Collidine 99%
  • Trimethylpyridine, 2,4,6-
  • 2,4,6-COLLIDIN pure
  • 2,4,6-Collidine, sym-Collidine
  • 1H-Tetrazole, 5-phenyl-, barium salt
  • Barium 5-phenyl-2,3,4-triaza-1-azanidacyclopenta-2,4-diene
  • 2,4,6-Trimethylpyridine ,99%
  • 2,4,6-Collidine,99%,electron microscopy grade
  • 2,4,6-Collidine,75%,tech.
  • 2,4,6-Trimethylpyridine,2,4,6-Collidine, sym-Collidine
  • 2,4,6-Trimethylpyrid
  • 2,4,6-Collidine, Reagent
  • 2,4,6-Collidine, 99% 100ML
  • 2,4,6-Collidine, 99% 500ML
  • 2,4,6-Collidine, electron microscopy grade, 99%
  • 2,4,6-Collidine, tech., 75%
  • 2,6 -Dimethylpyridine (2,4,6-dimethylpyridine)
  • 2,4,6-TRIMETHYLPYRIDINE(2,4,6-COLLIDINE)
  • 2,4,6-COLLIDINE: 97.5%
  • 2,4,6-COLLIDINE 2,4,6-TRIMETHYLPYRIDINE
  • 2,4,6-Collidine 98+ %
  • 2,4,6-Trimethylpyridine, 98.5%, for synthesis
  • 2,4,6-Trimethylpyridine &gt
  • 2,4,6-TRIMETHYLPYRIDINE FOR SYNTHESIS
  • 2 minus 2 - butyl can force
  • 2,4,6-Trimethylpyridinev
  • Aqualine Electrolyte AD-G, for Karl Fischer analysis
  • 2,4,6-Collidine pure, 98%
  • 246BD
  • 108-75-8
  • Puriss p.a.
  • General Use
  • Analytical Reagents
  • Analytical Chromatography Product Catalog
  • Heterocyclic Compounds