Benzamide

ChemicalBook > CAS DataBase List > Benzamide

Product Name: Benzamide
CAS No.: 55-21-0
Chemical Name: Benzamide
Synonyms: Benzamid;BENZOIC ACID AMIDE;NSC 3114;ai3-01031;BENZAMIDE;Carbonamide;BENZOYLAMIDE;BENZOIC AMIDE;Benzamide,99%;Benzamide >
CBNumber: CB6853808
Molecular Formula: C7H7NO
Formula Weight: 121.14
MOL File: 55-21-0.mol

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Benzamide Property

Melting point:: 125-128 °C (lit.)
Boiling point:: 228°C
Density: 1.341
vapor pressure: 0.000056 hPa (20 °C)
refractive index: 1.5323 (estimate)
Flash point:: 180°C
storage temp.: Store below +30°C.
solubility: ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to light yellow
form: Crystalline Powder
pka: 13.0(at 25℃)
color: White to almost white
PH: 6.9 (H2O)(saturated solution)
PH Range: 6.9
Water Solubility: 1.35 g/100 mL (20 ºC)
Merck: 14,1060
BRN: 385876
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
LogP: 0.640
CAS DataBase Reference: 55-21-0(CAS DataBase Reference)
NIST Chemistry Reference: Benzamide(55-21-0)
EPA Substance Registry System: Benzamide (55-21-0)

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Safety

Hazard Codes: Xn
Risk Statements: 22-68
Safety Statements: 22-24/25-36/37
WGK Germany: 1
RTECS: CU8700000
Autoignition Temperature: >500 °C
TSCA: Yes
HS Code: 29242995
Hazardous Substances Data: 55-21-0(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: 1125 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.02191
Product name: Benzamide
Purity: for synthesis
Packaging: 5G
Price: $46.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02191
Product name: Benzamide
Purity: for synthesis
Packaging: 250g
Price: $86
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02191
Product name: Benzamide
Purity: for synthesis
Packaging: 25kg
Price: $1280
Updated: 2024/03/01

Sigma-Aldrich

Product number: 135828
Product name: Benzamide
Purity: 99%
Packaging: 5g
Price: $37.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 135828
Product name: Benzamide
Purity: 99%
Packaging: 100g
Price: $63.3
Updated: 2024/03/01

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Benzamide Chemical Properties,Usage,Production

Description

Benzamide appears as off-white crystals or powder. It is combustible and incompatible with strong oxidising agents and strong bases. On combustion and thermal decomposition, it emits nitrogen oxides, carbon monoxide, and carbon dioxide.
Benzamide is a carbonic acid amide of benzoic acid. Benzamide exhibits an angle of about 15º with the plane of the amide group; this shows that benzamide molecule is not flat. The rotation of the amide group relative to the aromatic ring may result from the repulsion interaction between the hydrogen atoms of the amide group and those of the aromatic ring.

Chemical Properties

Benzamide is a combustible, colorless to beige, off-white, crystalline solid; freezing/melting point=132-133° C. It is slightly soluble in water, and soluble in many organic solvents.

Benzamide was used to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It was used to develop a robust screening method to study biotransformations using (+)-γ-lactamase enzyme.

Uses

Benzamide is utilized to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It is used as a nictoinamide-mimic PARP inhibitor and neuroprotectant. Further, it is used to develop a robust screening method to study biotransformations using (+)-gamma-lactamase enzyme. It is also employed in the determination of glycine. In addition to this, it is used as an intermediate in organic synthesis as well as in the production of pharmaceuticals and dyes.

Uses

Organic synthesis.
Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.

Definition

ChEBI: An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.

Preparation

Take a mixture of 5 ml concentrated ammonia and 5 ml water in a conical flask with a well-fitting cork. Add 2 ml (2.4 g.) benzoyl chloride, cork the flask and shake vigorously. Heat generates due to the reaction, hence hold the cork securely during shaking. After 15 min not even a trace of oily benzoyl chloride remains. Filter the fine flakes, wash with cold water and recrystallise from hot water: yield, 1-5 g. Colourless crystals of benzamide.

Preparation of benzamide from benzoyl chloride

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 4114, 1994 DOI: 10.1021/jo00094a021
Chemical and Pharmaceutical Bulletin, 39, p. 1152, 1991 DOI: 10.1248/cpb.39.1152
Synthetic Communications, 20, p. 1445, 1990 DOI: 10.1080/00397919008052860

General Description

White powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Benzamide reacts with azo and diazo compounds to generate toxic gases. Forms flammable gases with strong reducing agents. Mixing with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. Combustion generates toxic mixed oxides of nitrogen (NOx).

Hazard

Depresses the central nervous system; toxic.

Fire Hazard

Flash point data for Benzamide are not available, however Benzamide is probably combustible.

Biochem/physiol Actions

Inhibits poly(ADP-ribose) polymerase (PARP).

Clinical Use

Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.

Potential Exposure

Benzamide is used in organic synthesis.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

storage

Color Code—Green: General storage may be used.Store in a refrigerator or a cool, dry place.

Purification Methods

Crystallise it from hot water (about 5mL/g), EtOH or 1,2-dichloroethane, and dry it in air. It has also been crystallised from dilute aqueous NH3, H2O, Me2CO, then *C6H6 using a Soxhlet extractor. Dry it in an oven at 110o for 8hours and store in a desiccator over 99% H2SO4. [Bates & Hobbs J Am Chem Soc 73 2151 1951, Beilstein 9 IV 725.]

Benzamide Preparation Products And Raw materials

Raw materials

Glass-lined reaction pot Benzoyl chloride Ammonium carbonate

Preparation Products

BENZOYL ISOCYANATE (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Methyl anthranilate Bifenthrin Butyl 2-[[3-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-hydroxy-1-naphthyl]azo]benzoate Pigment Red 175 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID Procainamide hydrochloride Benzonitrile brotianide 4-Piperidinone Cisapride 2-Phenylindole

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View Lastest Price from Benzamide manufacturers

CONTIDE BIOTECH CO.,LTD

Product: Benzamide 55-21-0
Price: US $0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 20
Release date: 2024-03-27

Hebei Guanlang Biotechnology Co., Ltd.

Product: Benzamide 55-21-0
Price: US $10.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-04-06

Hebei Mojin Biotechnology Co., Ltd

Product: Benzamide 55-21-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-24

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