Benzamide
- Product Name
- Benzamide
- CAS No.
- 55-21-0
- Chemical Name
- Benzamide
- Synonyms
- Benzamid;BENZOIC ACID AMIDE;NSC 3114;ai3-01031;BENZAMIDE;Carbonamide;BENZOYLAMIDE;BENZOIC AMIDE;Benzamide,99%;Benzamide >
- CBNumber
- CB6853808
- Molecular Formula
- C7H7NO
- Formula Weight
- 121.14
- MOL File
- 55-21-0.mol
Benzamide Property
- Melting point:
- 125-128 °C (lit.)
- Boiling point:
- 228°C
- Density
- 1.341
- vapor pressure
- 0.000056 hPa (20 °C)
- refractive index
- 1.5323 (estimate)
- Flash point:
- 180°C
- storage temp.
- Store below +30°C.
- solubility
- ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to light yellow
- form
- Crystalline Powder
- pka
- 13.0(at 25℃)
- color
- White to almost white
- PH
- 6.9 (H2O)(saturated solution)
- PH Range
- 6.9
- Water Solubility
- 1.35 g/100 mL (20 ºC)
- Merck
- 14,1060
- BRN
- 385876
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- LogP
- 0.640
- CAS DataBase Reference
- 55-21-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzamide(55-21-0)
- EPA Substance Registry System
- Benzamide (55-21-0)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-68
- Safety Statements
- 22-24/25-36/37
- WGK Germany
- 1
- RTECS
- CU8700000
- Autoignition Temperature
- >500 °C
- TSCA
- Yes
- HS Code
- 29242995
- Hazardous Substances Data
- 55-21-0(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 1125 mg/kg
N-Bromosuccinimide Price
- Product number
- 8.02191
- Product name
- Benzamide
- Purity
- for synthesis
- Packaging
- 5G
- Price
- $46.4
- Updated
- 2024/03/01
- Product number
- 8.02191
- Product name
- Benzamide
- Purity
- for synthesis
- Packaging
- 250g
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 8.02191
- Product name
- Benzamide
- Purity
- for synthesis
- Packaging
- 25kg
- Price
- $1280
- Updated
- 2024/03/01
- Product number
- 135828
- Product name
- Benzamide
- Purity
- 99%
- Packaging
- 5g
- Price
- $37.3
- Updated
- 2024/03/01
- Product number
- 135828
- Product name
- Benzamide
- Purity
- 99%
- Packaging
- 100g
- Price
- $63.3
- Updated
- 2024/03/01
Benzamide Chemical Properties,Usage,Production
Description
Benzamide appears as off-white crystals or powder. It is combustible and incompatible with strong oxidising agents and strong bases. On combustion and thermal decomposition, it emits nitrogen oxides, carbon monoxide, and carbon dioxide.
Benzamide is a carbonic acid amide of benzoic acid. Benzamide exhibits an angle of about 15º with the plane of the amide group; this shows that benzamide molecule is not flat. The rotation of the amide group relative to the aromatic ring may result from the repulsion interaction between the hydrogen atoms of the amide group and those of the aromatic ring.
Chemical Properties
Benzamide is a combustible, colorless to beige, off-white, crystalline solid; freezing/melting point=132-133° C. It is slightly soluble in water, and soluble in many organic solvents.
Benzamide was used to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It was used to develop a robust screening method to study biotransformations using (+)-γ-lactamase enzyme.
Uses
Benzamide is utilized to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It is used as a nictoinamide-mimic PARP inhibitor and neuroprotectant. Further, it is used to develop a robust screening method to study biotransformations using (+)-gamma-lactamase enzyme. It is also employed in the determination of glycine. In addition to this, it is used as an intermediate in organic synthesis as well as in the production of pharmaceuticals and dyes.
Uses
Organic synthesis.
Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.
Definition
ChEBI: An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.
Preparation
Take a mixture of 5 ml concentrated ammonia and 5 ml water in a conical flask with a well-fitting cork. Add 2 ml (2.4 g.) benzoyl chloride, cork the flask and shake vigorously. Heat generates due to the reaction, hence hold the cork securely during shaking. After 15 min not even a trace of oily benzoyl chloride remains. Filter the fine flakes, wash with cold water and recrystallise from hot water: yield, 1-5 g. Colourless crystals of benzamide.
Preparation of benzamide from benzoyl chloride
Synthesis Reference(s)
The Journal of Organic Chemistry, 59, p. 4114, 1994 DOI: 10.1021/jo00094a021
Chemical and Pharmaceutical Bulletin, 39, p. 1152, 1991 DOI: 10.1248/cpb.39.1152
Synthetic Communications, 20, p. 1445, 1990 DOI: 10.1080/00397919008052860
General Description
White powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Benzamide reacts with azo and diazo compounds to generate toxic gases. Forms flammable gases with strong reducing agents. Mixing with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. Combustion generates toxic mixed oxides of nitrogen (NOx).
Hazard
Depresses the central nervous system; toxic.
Fire Hazard
Flash point data for Benzamide are not available, however Benzamide is probably combustible.
Biochem/physiol Actions
Inhibits poly(ADP-ribose) polymerase (PARP).
Clinical Use
Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.
Potential Exposure
Benzamide is used in organic synthesis.
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
storage
Color Code—Green: General storage may be used.Store in a refrigerator or a cool, dry place.
Purification Methods
Crystallise it from hot water (about 5mL/g), EtOH or 1,2-dichloroethane, and dry it in air. It has also been crystallised from dilute aqueous NH3, H2O, Me2CO, then *C6H6 using a Soxhlet extractor. Dry it in an oven at 110o for 8hours and store in a desiccator over 99% H2SO4. [Bates & Hobbs J Am Chem Soc 73 2151 1951, Beilstein 9 IV 725.]
Benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzamide manufacturers
- Product
- Benzamide 55-21-0
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 20
- Release date
- 2024-03-27
- Product
- Benzamide 55-21-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-11
- Product
- Benzamide 55-21-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-24