Trimethyl phosphite

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Trimethyl phosphite

Product Name: Trimethyl phosphite
CAS No.: 121-45-9
Chemical Name: Trimethyl phosphite
Synonyms: P(OMe)3;P(OCH3)3;PHOSPHOROUS ACID TRIMETHYL ESTER;Trimethoxyphosphine;TrimethyPhosphite;AURORA KA-1230;Trimethylfosfit;Trimethoxyfosfin;METHYL PHOSPHITE;Trimethylphosphit
CBNumber: CB7100684
Molecular Formula: C3H9O3P
Formula Weight: 124.08
MOL File: 121-45-9.mol

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Trimethyl phosphite Property

Melting point:: −78 °C(lit.)
Boiling point:: 111-112 °C(lit.)
Density: 1.052 g/mL at 25 °C(lit.)
vapor density: 4.3 (vs air)
vapor pressure: 17 mm Hg ( 20 °C)
refractive index: n20/D 1.408(lit.)
Flash point:: 82 °F
storage temp.: 2-8°C
solubility: Chloroform, DMSO (Sparingly)
form: Liquid
color: Colorless
Specific Gravity: 1.052
explosive limit: 5.2-61.2%(V)
Water Solubility: Hydrolyzes with water.
Sensitive: Air & Moisture Sensitive
Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions
BRN: 956570
Exposure limits: TLV-TWA 10 mg/m³ (2 ppm) (ACGIH).
Stability:: Moisture Sensitive
CAS DataBase Reference: 121-45-9(CAS DataBase Reference)
NIST Chemistry Reference: Phosphorous acid, trimethyl ester(121-45-9)
EPA Substance Registry System: Trimethyl phosphite (121-45-9)

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Safety

Hazard Codes: Xn,T,F,Xi
Risk Statements: 10-22-36/37/38-41-37/38-65-48/23/24/25-11-46-45-67-66-36
Safety Statements: 26-39-62-45-16-53
RIDADR: UN 2329 3/PG 3
WGK Germany: 1
RTECS: TH1400000
F: 10-13-21
Autoignition Temperature: 250 °C
TSCA: Yes
HS Code: 2920 23 00
HazardClass: 3
PackingGroup: III
Hazardous Substances Data: 121-45-9(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: 1600 mg/kg LD50 dermal Rabbit 2600 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.00553
Product name: Trimethyl phosphite
Purity: for synthesis
Packaging: 100mL
Price: $48.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.00553
Product name: Trimethyl phosphite
Purity: for synthesis
Packaging: 500mL
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: 240907
Product name: Trimethyl phosphite
Purity: ≥99%
Packaging: 25g
Price: $44.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 240907
Product name: Trimethyl phosphite
Purity: ≥99%
Packaging: 100g
Price: $102
Updated: 2024/03/01

Alfa Aesar

Product number: 030132
Product name: Trimethyl phosphite, 97%
Packaging: 100g
Price: $43.8
Updated: 2023/06/20

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Trimethyl phosphite Chemical Properties,Usage,Production

Chemical Properties

Trimethyl phosphite is a colorless liquid. Distinctive pungent, pyridine-like odor. The Odor Threshold is 0.0001 ppm.

Uses

Trimethyl phosphite has been used primarily as an intermediate in the manufacture of pesticides and the synthesis of organophosphate insecticides. It is also used as a fire retardants in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst.

Production Methods

Produced via a reaction between phosphorus trichloride and methanol in the presence of a tertiary amine catalyst such as diethylaniline.

Definition

ChEBI: Trimethyl phosphite is an organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds. It has a role as an alkylating agent.

Reactions

The reaction of trimethyl phosphite and dimethyl acetylenedicarboxylate in the presence of dimedone as the proton source/nucleophile leads to 2-(dimethoxy-phosphoryl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-succinic acid dimethyl ester in 91 % yields.
It reacts with a catalytic amount of methyl iodide in the Arbuzov reaction to give dimethyl methylphosphonate:
P(OCH3)3 → CH3P(O)(OCH3)2
It is susceptible to oxidation to trimethyl phosphate.

General Description

Trimethyl phosphite appears as a clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in water. Vapors heavier than air. It is used in making pesticides, flame retardants and organophosphorous additives.

Air & Water Reactions

Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol. Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol. The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC).

Reactivity Profile

As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).

Health Hazard

Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.
LD50 value, oral (rats): 1600 mg/kg
Teratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite.
The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..

Fire Hazard

Special Hazards of Combustion Products: Toxic fumes of PO x

Safety Profile

Moderately toxic by ingestion and skin contact. An experimental teratogen. A severe skin and eye irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use water, foam, fog, CO2. Violent explosive reaction on contact with magnesium perchlorate or trimethyl platinum(IV) azide tetramer. When heated to decomposition it emits toxic fumes of POx. An intermediate in the production of pesticides, fire retardants, and organic phosphorus additives. See also ESTERS.

Potential Exposure

Trimethyl phosphite is a flame retardant, and used as an intermediate in the manufacture of a number of pesticides, and organophosphorus additives.

Carcinogenicity

Trimethyl phosphite was genotoxic in mouse lymphoma assays but was not mutagenic in various bacterial assays.

Shipping

UN2329 Trimethyl phosphite, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]

Incompatibilities

Vaor May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Violent reaction with magnesium perchlorate. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts (hydrolyzes) with water. Incompatible with air, moisture.

Waste Disposal

Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.

Trimethyl phosphite Preparation Products And Raw materials

Raw materials

Organic base Triphenyl phosphite Sodium Methoxide N,N-Dimethylaniline 1,2-Dichlorobenzene AMMONIUM CARBAMATE

Preparation Products

Tetrachlorvinphos Phosphite Flame retardant for pure-dacron MEVINPHOS 6-Bromoisoquinoline HEPTENOPHOS Dichlorvos 1,4-BIS(2-METHYLSTYRYL)BENZENE 6-(bromomethyl)isoquinoline (Aminomethyl)phosphonic acid 6-Methylisoquinoline Capsaicin Dimethyl acetylmethylphosphonate Flame retardant for fabric Triadimefon PHOSPHAMIDON Glyphosate fluorescent whitening agent ATS-X Monocrotophos 8-METHYL-ISOQUINOLINE

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View Lastest Price from Trimethyl phosphite manufacturers

Henan Fengda Chemical Co., Ltd

Product: Trimethyl phosphite 121-45-9
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-23

Hebei Duling International Trade Co. LTD

Product: Trimethyl phosphite 121-45-9
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-05-25

Hebei Mojin Biotechnology Co., Ltd

Product: Trimethyl phosphite 121-45-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-29

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