Trimethyl phosphite
- Product Name
- Trimethyl phosphite
- CAS No.
- 121-45-9
- Chemical Name
- Trimethyl phosphite
- Synonyms
- P(OMe)3;P(OCH3)3;PHOSPHOROUS ACID TRIMETHYL ESTER;Trimethoxyphosphine;TrimethyPhosphite;AURORA KA-1230;Trimethylfosfit;Trimethoxyfosfin;METHYL PHOSPHITE;Trimethylphosphit
- CBNumber
- CB7100684
- Molecular Formula
- C3H9O3P
- Formula Weight
- 124.08
- MOL File
- 121-45-9.mol
Trimethyl phosphite Property
- Melting point:
- −78 °C(lit.)
- Boiling point:
- 111-112 °C(lit.)
- Density
- 1.052 g/mL at 25 °C(lit.)
- vapor density
- 4.3 (vs air)
- vapor pressure
- 17 mm Hg ( 20 °C)
- refractive index
- n20/D 1.408(lit.)
- Flash point:
- 82 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, DMSO (Sparingly)
- form
- Liquid
- color
- Colorless
- Specific Gravity
- 1.052
- explosive limit
- 5.2-61.2%(V)
- Water Solubility
- Hydrolyzes with water.
- Sensitive
- Air & Moisture Sensitive
- Hydrolytic Sensitivity
- 4: no reaction with water under neutral conditions
- BRN
- 956570
- Exposure limits
- TLV-TWA 10 mg/m3 (2 ppm) (ACGIH).
- Stability:
- Moisture Sensitive
- CAS DataBase Reference
- 121-45-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Phosphorous acid, trimethyl ester(121-45-9)
- EPA Substance Registry System
- Trimethyl phosphite (121-45-9)
Safety
- Hazard Codes
- Xn,T,F,Xi
- Risk Statements
- 10-22-36/37/38-41-37/38-65-48/23/24/25-11-46-45-67-66-36
- Safety Statements
- 26-39-62-45-16-53
- RIDADR
- UN 2329 3/PG 3
- OEB
- B
- OEL
- TWA: 2 ppm (10 mg/m3)
- WGK Germany
- 1
- RTECS
- TH1400000
- F
- 10-13-21
- Autoignition Temperature
- 250 °C
- TSCA
- Yes
- HS Code
- 2920 23 00
- HazardClass
- 3
- PackingGroup
- III
- Hazardous Substances Data
- 121-45-9(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 1600 mg/kg LD50 dermal Rabbit 2600 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 8.00553
- Product name
- Trimethyl phosphite
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $48.3
- Updated
- 2024/03/01
- Product number
- 8.00553
- Product name
- Trimethyl phosphite
- Purity
- for synthesis
- Packaging
- 500mL
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 240907
- Product name
- Trimethyl phosphite
- Purity
- ≥99%
- Packaging
- 25g
- Price
- $44.4
- Updated
- 2024/03/01
- Product number
- 240907
- Product name
- Trimethyl phosphite
- Purity
- ≥99%
- Packaging
- 100g
- Price
- $102
- Updated
- 2024/03/01
- Product number
- 030132
- Product name
- Trimethyl phosphite, 97%
- Packaging
- 100g
- Price
- $43.8
- Updated
- 2023/06/20
Trimethyl phosphite Chemical Properties,Usage,Production
Chemical Properties
Trimethyl phosphite is a colorless liquid. Distinctive pungent, pyridine-like odor. The Odor Threshold is 0.0001 ppm.
Uses
Trimethyl phosphite has been used primarily as an intermediate in the manufacture of pesticides and the synthesis of organophosphate insecticides. It is also used as a fire retardants in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst.
Production Methods
Produced via a reaction between phosphorus trichloride and methanol in the presence of a tertiary amine catalyst such as diethylaniline.
Definition
ChEBI: Trimethyl phosphite is an organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds. It has a role as an alkylating agent.
Reactions
The reaction of trimethyl phosphite and dimethyl acetylenedicarboxylate in the presence of dimedone as the proton source/nucleophile leads to 2-(dimethoxy-phosphoryl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-succinic acid dimethyl ester in 91 % yields.
It reacts with a catalytic amount of methyl iodide in the Arbuzov reaction to give dimethyl methylphosphonate:
P(OCH3)3 → CH3P(O)(OCH3)2
It is susceptible to oxidation to trimethyl phosphate.
General Description
Trimethyl phosphite appears as a clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in water. Vapors heavier than air. It is used in making pesticides, flame retardants and organophosphorous additives.
Air & Water Reactions
Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol. Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol. The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC).
Reactivity Profile
As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).
Health Hazard
Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.
LD50 value, oral (rats): 1600 mg/kg
Teratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite.
The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..
Fire Hazard
Special Hazards of Combustion Products: Toxic fumes of PO x
Safety Profile
Moderately toxic by ingestion and skin contact. An experimental teratogen. A severe skin and eye irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use water, foam, fog, CO2. Violent explosive reaction on contact with magnesium perchlorate or trimethyl platinum(IV) azide tetramer. When heated to decomposition it emits toxic fumes of POx. An intermediate in the production of pesticides, fire retardants, and organic phosphorus additives. See also ESTERS.
Potential Exposure
Trimethyl phosphite is a flame retardant, and used as an intermediate in the manufacture of a number of pesticides, and organophosphorus additives.
Carcinogenicity
Trimethyl phosphite was genotoxic in mouse lymphoma assays but was not mutagenic in various bacterial assays.
Shipping
UN2329 Trimethyl phosphite, Hazard Class: 3; Labels: 3-Flammable liquid.
Purification Methods
Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]
Incompatibilities
Vaor May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Violent reaction with magnesium perchlorate. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts (hydrolyzes) with water. Incompatible with air, moisture.
Waste Disposal
Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.
Trimethyl phosphite Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimethyl phosphite manufacturers
- Product
- Trimethyl phosphite 121-45-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2021-09-27
- Product
- Trimethyl phosphite 121-45-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-23
- Product
- Trimethyl phosphite 121-45-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-29