ChemicalBook > CAS DataBase List > 3-Aminopyrazine-2-carboxylic acid
3-Aminopyrazine-2-carboxylic acid
- Product Name
- 3-Aminopyrazine-2-carboxylic acid
- CAS No.
- 5424-01-1
- Chemical Name
- 3-Aminopyrazine-2-carboxylic acid
- Synonyms
- 3-AMINO-2-PYRAZINECARBOXYLIC ACID;NSC 13148;Deacetylhypnosin;TIMTEC-BB SBB004179;3-Aminopyrazine-2-ca;3-Aminopyrazinoic acid;2-Amino-3-pyrazinecarboxyL;3-AMINOPYRAZINE-2-CARBOXYLIC ACID;3-Aminophrazine-2-carboxylic acid;2-Aminopyrazine-3-carboxylic acid
- CBNumber
- CB7103665
- Molecular Formula
- C5H5N3O2
- Formula Weight
- 139.11
- MOL File
- 5424-01-1.mol
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3-Aminopyrazine-2-carboxylic acid Property
- Melting point:
- 205-210 °C (dec.) (lit.)
- Boiling point:
- 255.04°C (rough estimate)
- Density
- 1.4551 (rough estimate)
- refractive index
- 1.5900 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Sparingly) , Methanol (Slightly)
- pka
- 3.65±0.10(Predicted)
- form
- Crystalline Powder
- color
- Yellow-greenish
- BRN
- 124835
- InChI
- InChI=1S/C5H5N3O2/c6-4-3(5(9)10)7-1-2-8-4/h1-2H,(H2,6,8)(H,9,10)
- InChIKey
- ZAGZIOYVEIDDJA-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=CN=C1N
- LogP
- -3.1 at 20℃ and pH7
- Surface tension
- 73.6mN/m at 1g/L and 20℃
- CAS DataBase Reference
- 5424-01-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- A76982
- Product name
- 3-Amino-2-pyrazinecarboxylic acid
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $22.3
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- A76982
- Product name
- 3-Amino-2-pyrazinecarboxylic acid
- Purity
- ≥99%
- Packaging
- 25g
- Price
- $40.2
- Updated
- 2025/07/31
TCI Chemical
- Product number
- A0848
- Product name
- 3-Aminopyrazine-2-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $62
- Updated
- 2025/07/31
TCI Chemical
- Product number
- A0848
- Product name
- 3-Aminopyrazine-2-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $184
- Updated
- 2025/07/31
TRC
- Product number
- A628925
- Product name
- 3-Amino-2-pyrazinecarboxylic acid
- Packaging
- 100g
- Price
- $160
- Updated
- 2021/12/16
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3-Aminopyrazine-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Pale Brown Crystalline Solid
Uses
Antidiabetic
Synthesis
16298-03-6
5424-01-1
General procedure for the synthesis of 3-aminopyrazine-2-carboxylic acid from methyl 3-aminopyrazine-2-carboxylate: Methyl 3-aminopyrazine-2-carboxylate (2.08 g, 13.6 mmol) was suspended in methanol (40 mL) under nitrogen protection, and treated with 1N aqueous sodium hydroxide (30 mL). The reaction mixture was warmed up to room temperature and stirred for 50 min. Subsequently, methanol (about 45 mL) was partially evaporated under reduced pressure. The resulting mixture was cooled in an ice water bath and 1N aqueous hydrochloric acid solution (70 mL) was slowly added. Initially the mixture appeared as a solution and gradually a precipitate was generated with further addition of acid. The solid product was collected by filtration, washed with water (3 x 10 mL) and finally dried under vacuum to give 1.48 g of the target product 3-aminopyrazine-2-carboxylic acid.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[2] Patent: WO2013/169907, 2013, A1. Location in patent: Page/Page column 44
3-Aminopyrazine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Aminopyrazine-2-carboxylic acid manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 3-Aminopyrazine-2-carboxylic acid 5424-01-1
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500KGS
- Release date
- 2021-06-04
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 3-Aminopyrazine-2-carboxylic acid 5424-01-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
R&D Scientific Inc.
- Product
- 3-Aminopyrazine-2-carboxylic acid 5424-01-1
- Price
- US $1190.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 5000 Kg
- Release date
- 2025-03-28
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