5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)
- Product Name
- 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)
- CAS No.
- 20090-69-1
- Chemical Name
- 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)
- Synonyms
- NSC 243816;2-Chloro-4-MethylpyriMidin-5-aMine;5-Amino-2-chloro-4-methylpyrimidine;5-PyriMidinaMine, 2-chloro-4-Methyl-;2-chloro-4-methyl-pyrimidin-5-ylamine;5-Pyrimidinamine, 2-chloro-4-methyl- (9CI);5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB71082097
- Molecular Formula
- C5H6ClN3
- Formula Weight
- 143.57
- MOL File
- 20090-69-1.mol
5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) Property
- Melting point:
- 93.5℃
- Boiling point:
- 309.4±22.0 °C(Predicted)
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.36±0.29(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C5H6ClN3/c1-3-4(7)2-8-5(6)9-3/h2H,7H2,1H3
- InChIKey
- RZAKVHVZRSQZEQ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(N)C(C)=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H331Toxic if inhaled
H401Toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A595670
- Product name
- 5-Amino-2-chloro-4-methylpyrimidine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC153804
- Product name
- 2-Chloro-4-methylpyrimidin-5-amine
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- W4245
- Product name
- 2-Chloro-4-methylpyrimidin-5-amine
- Packaging
- 250mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- FC153804
- Product name
- 2-Chloro-4-methylpyrimidin-5-amine
- Packaging
- 500mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FC153804
- Product name
- 2-Chloro-4-methylpyrimidin-5-amine
- Packaging
- 1g
- Price
- $332.5
- Updated
- 2021/12/16
5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
13162-26-0
20090-69-1
The general procedure for the synthesis of 5-amino-2-chloro-4-methylpyrimidine from 2,4-dichloro-5-nitro-6-methylpyrimidine was as follows: to a stirred methanol (100 mL) solution of 2,4-dichloro-6-methyl-5-nitropyrimidine (10 g, 48.1 mmol) and ammonium chloride (25.7 g, 481 mmol) under nitrogen protection was added in batches zinc powder ( 31.4 g, 481 mmol). The reaction mixture was stirred at 70 °C for 50 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 30:1). All fractions containing the target product were collected and detected by thin layer chromatography (unfolding agent: ethyl acetate/petroleum ether, 1:1, Rf=0.6), combined and concentrated to give 2-chloro-4-methylpyrimidin-5-amine (2 g, 13.93 mmol, 29.0% yield) as a light yellow solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.95 (s, 1H), 3.66 (s, 2H), 2.88 (s, 3H); ESI-MS m/z: 144.2 ([M+H]+).
References
[1] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 138
[2] Chemische Berichte, 1901, vol. 34, p. 1242
[3] Yakugaku Zasshi, 1942, vol. 62, p. 315,333; dtsch. Ref. S. 95, 106
[4] Chem.Abstr., 1951, p. 5150
[5] Patent: EP2100894, 2009, A1. Location in patent: Page/Page column 20
5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) manufacturers
- Product
- 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) 20090-69-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) 20090-69-1
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10