2-Bromo-5-fomylthiazole

Product Name: 2-Bromo-5-fomylthiazole
CAS No.: 464192-28-7
Chemical Name: 2-Bromo-5-fomylthiazole
Synonyms: 4-BROMOTHIAZOLE-2-CARBALDEHYDE;2-broMo-1,3-thiazole-5-carbaldehyde;CAS:464192-28-7;2-Bromo-5-formyL;2-Bromo-5-fomylthiazole;2-BROMO-5-FORMYLTHIAZOLE;2-Bromo-5-formylthiazole ,98%;2-Bromo-5-formyl-1,3-thiazole;2-Bromothiazole-5-carboxaldehy;2-Bromo-5-thiazolecarbaldehyde
CBNumber: CB7119756
Molecular Formula: C4H2BrNOS
Formula Weight: 192.03
MOL File: 464192-28-7.mol

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2-Bromo-5-fomylthiazole Property

Melting point:: 94-96°C
Boiling point:: 264.9±13.0 °C(Predicted)
Density: 1.920±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: Crystalline Powder
pka: -0.94±0.10(Predicted)
color: White to yellow
InChI: InChI=1S/C4H2BrNOS/c5-4-6-1-3(2-7)8-4/h1-2H
InChIKey: DJUWIZUEHXRECB-UHFFFAOYSA-N
SMILES: S1C(C=O)=CN=C1Br
CAS DataBase Reference: 464192-28-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-43-36-22
Safety Statements: 26-36/37/39-36/37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 756865
Product name: 2-Bromothiazole-5-carboxaldehyde
Purity: 97%
Packaging: 500mg
Price: $121
Updated: 2023/06/20

TRC

Product number: B688275
Product name: 2-Bromothiazole-5-carboxaldehyde
Packaging: 5g
Price: $440
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB149591
Product name: 2-Bromo-5-formylthiazole
Packaging: 5G
Price: $489
Updated: 2021/12/16

Matrix Scientific

Product number: 069437
Product name: 2-Bromo-5-formylthiazole
Purity: 97%
Packaging: 25g
Price: $519
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK125108
Product name: 2-Bromothiazole-5-carboxaldehyde
Purity: 98%
Packaging: 1g
Price: $215
Updated: 2021/12/16

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2-Bromo-5-fomylthiazole Chemical Properties,Usage,Production

Chemical Properties

Yellow powder

Uses

2-Bromothiazole-5-carboxaldehyde is a reactant in the preparation of thienopyridines as potent checkpoint 1 kinase (CHK1) inhibitors.

Synthesis

687636-93-7

464192-28-7

General procedure for the synthesis of 2-bromo-5-formylthiazole from 2-bromothiazole-5-methanol: Manganese dioxide (3.8 g, 37.10 mmol) was added to a solution of 2-bromothiazole-5-methanol (1.44 g, 7.42 mmol) in trichloromethane (20 mL). The reaction mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 2-bromo-5-formylthiazole (870 mg, 61% yield) as a white solid. The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectrum (1H-NMR, 400 MHz, CDCl3): δ 9.95 (s, 1H), 8.16 (s, 1H); nuclear magnetic resonance carbon spectrum (13C-NMR, 100 MHz, CDCl3): δ 180.93, 150.47, 145.48, 142.91; mass spectra (ESI): m/z 192.31 ([MH+]).

References

[1] Patent: WO2008/61795, 2008, A2. Location in patent: Page/Page column 61-62

2-Bromo-5-fomylthiazole Preparation Products And Raw materials

Raw materials

2-Bromothiazole Ammonium hydroxide Acetonitrile Sodium ethoxide tert-Butyl nitrite Cuprous bromide 2-Bromomalonaldehyde Methyl formate Cupric bromide Thiourea Methyl chloroacetate

Preparation Products

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2-Bromo-5-fomylthiazole Suppliers

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View Lastest Price from 2-Bromo-5-fomylthiazole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Bromo-5-fomylthiazole 464192-28-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Bromo-5-fomylthiazole 464192-28-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 2-Bromo-5-fomylthiazole 464192-28-7
Price: US $1.80/KG
Min. Order: 1g
Purity: 90.0%-99.9%
Supply Ability: 800kg
Release date: 2020-03-20

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CAS:464192-28-7

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464192-28-7

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