5-Phenylthiophene-2-carboxylic acid
Uses- Product Name
- 5-Phenylthiophene-2-carboxylic acid
- CAS No.
- 19163-24-7
- Chemical Name
- 5-Phenylthiophene-2-carboxylic acid
- Synonyms
- AKOS B029964;AKOS BAR-0576;BUTTPARK 98\04-16;RARECHEM AL BE 0489;5-Phenyl-2-thenoic Acid;2-Carboxy-5-phenylthiophene;5-phenyl-2-furancarbothioic S-acid;5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID;5-PHENYL-2-THIOPHENECARBOXYLIC ACID;2-Thiophenecarboxylic acid, 5-phenyl-
- CBNumber
- CB7123393
- Molecular Formula
- C11H8O2S
- Formula Weight
- 204.24
- MOL File
- 19163-24-7.mol
5-Phenylthiophene-2-carboxylic acid Property
- Melting point:
- 186-190°C
- Boiling point:
- 393.6±30.0 °C(Predicted)
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- powder to crystal
- pka
- 3.52±0.10(Predicted)
- color
- White to Orange to Green
- λmax
- 310nm(EtOH)(lit.)
- CAS DataBase Reference
- 19163-24-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L498998
- Product name
- 5-PHENYL-2-THIOPHENECARBOXYLIC ACID
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $42.8
- Updated
- 2025/07/31
- Product number
- L498998
- Product name
- 5-PHENYL-2-THIOPHENECARBOXYLIC ACID
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $41.5
- Updated
- 2024/03/01
- Product number
- P2347
- Product name
- 5-Phenyl-2-thiophenecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 250mg
- Price
- $51
- Updated
- 2025/07/31
- Product number
- P2347
- Product name
- 5-Phenyl-2-thiophenecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $149
- Updated
- 2025/07/31
- Product number
- P320933
- Product name
- 5-Phenylthiophene-2-carboxylicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
5-Phenylthiophene-2-carboxylic acid Chemical Properties,Usage,Production
Uses
Thiophene derivatives are widely used in the synthesis of pesticides, pharmaceuticals, chemical reagents, dyes, and polymer auxiliaries. 5-Phenylen-2-carboxylic acid has extensive applications in organic synthesis.
Definition
ChEBI: 5-Phenylthiophene-2-carboxylic acid is a thiophenecarboxylic acid.
Synthesis
14597-62-7
19163-24-7
GENERAL STEPS: To a mixed solution of methanol (5 mL) and tetrahydrofuran (5 mL) of 2-methoxycarbonyl-5-phenylthiophene (437 mg) was added 1 N aqueous sodium hydroxide (3 mL), and the reaction was stirred for 2 hours at room temperature. After completion of the reaction, 1 N hydrochloric acid (5 mL) was slowly added to the reaction mixture for acidification. The precipitated solid was collected by filtration and washed with a small amount of cold water and dried under vacuum to give 5-phenylthiophene-2-carboxylic acid (397 mg, 97.1% yield). The product was confirmed by NMR hydrogen spectrum (DMSO-d6, δ): 7.3-7.5 (3H, m), 7.58 (1H, d, J = 3.9 Hz), 7.6-7.8 (3H, m), 13.15 (1H, wide s). Electrospray mass spectrometry (ESI-MS) showed m/z: 203 ([M-H]-).
References
[1] Patent: US6770667, 2004, B1. Location in patent: Page column 11
[2] ChemMedChem, 2011, vol. 6, # 2, p. 362 - 377
[3] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5536 - 5548
5-Phenylthiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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