Raubasine

ChemicalBook > CAS DataBase List > Raubasine

Product Name: Raubasine
CAS No.: 483-04-5
Chemical Name: Raubasine
Synonyms: Tensyl;Sarpan;Vincain;Vincein;Lamuran;Ranitol;RAUBASIN;Vinceine;Vincaine;Raubasil
CBNumber: CB7129678
Molecular Formula: C21H24N2O3
Formula Weight: 352.43
MOL File: 483-04-5.mol

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Raubasine Property

Melting point:: 258°C (rough estimate)
Boiling point:: 486.04°C (rough estimate)
alpha: D20 -60° (c = 0.5 in chloroform); D20 -45° (c = 0.5 in pyridine); D20 -39° (c = 0.25 in methanol)
Density: 1.1823 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: pK1:10.55(+1) (25°C)
color: Pale Yellow
optical activity: [α]/D -65±3°, c = 1 in chloroform
Water Solubility: insoluble in water
BRN: 97268
LogP: 2.880 (est)
NIST Chemistry Reference: Ajmalicine(483-04-5)

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Safety

Hazard Codes: Xn
Risk Statements: 25-22
Safety Statements: 22-45
RIDADR: 1544
WGK Germany: 3
RTECS: AX7875000
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 41111
Product name: Ajmalicine
Purity: ≥98.0% (HPLC)
Packaging: 50mg
Price: $112.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 41111
Product name: Ajmalicine
Purity: ≥98.0% (HPLC)
Packaging: 10mg
Price: $77.7
Updated: 2023/06/20

Sigma-Aldrich

Product number: R751618
Product name: AJMALICINE
Purity: AldrichCPR
Packaging: 50MG
Price: $97.9
Updated: 2022/05/15

TRC

Product number: R127000
Product name: Raubasine
Packaging: 50mg
Price: $185
Updated: 2021/12/16

Usbiological

Product number: 288595
Product name: Raubasine
Packaging: 5g
Price: $345
Updated: 2021/12/16

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Raubasine Chemical Properties,Usage,Production

Description

Vinca rosea L. yields this alkaloid which crystallizes as colourless needles from MeOH. The base is laevorotatory having a specific rotation of [α]_D_620 (MeOH) and forms a crystalline hydrochloride, m.p. 281-3°e. The structure given above has been elucidated from chemical and spectroscopic data.

Uses

Antihypertensive, anti-ischemic.

Uses

Antihypertensive, anti-ischemic (cerebral and peripheral)

Definition

ChEBI: Ajmalicine is a monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure. It has a role as an antihypertensive agent, an alpha-adrenergic antagonist and a vasodilator agent. It is a monoterpenoid indole alkaloid, a methyl ester and an organic heteropentacyclic compound. It is a conjugate base of an ajmalicine(1+).

target

P450 (e.g. CYP17)

Purification Methods

It crystallises from MeOH, EtOH or EtOAc. [Beilstein 27 III/IV 7927.]

References

Janot, Le Men, Cornpt. Rend., 243, 1786 (1956) Shamma, Moss, J. Arner. Chern. Soc., 83, 5038 (1961) Abdurakhsimova, Yuldashev, Yunusov, Khirn. Prir. Soedin., 1,224 (1965)

Raubasine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Raubasine manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Raubasine 483-04-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-07

Hebei Fengqiang Trading Co., LTD

Product: Raubasine 483-04-5
Price: US $100.00/bag
Min. Order: 1bag
Purity: 99
Supply Ability: 5000
Release date: 2023-09-14

Henan Bao Enluo International TradeCo.，LTD

Product: Raubasine 483-04-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-08-17

483-04-5, RaubasineRelated Search:

Bensulfuron methyl Methylparaben Kresoxim-methyl Methyl acrylate Methyl Methyl bromide almitrine-raubasine Parathion-methyl Methyl 4-piperidineacetate 4-Piperidineethanol 1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE Isobutyl vinyl ether RAUBASINE HYDROCHLORIDE,δ-Yohimbine hydrochloride, Raubasine hydrochloride 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE (1-Methyl-piperidin-4-yl)-acetaldehyde Vinyl isopropyl ether 2,4-Dimethylpiperidine AJMALINE

RAUBASIN

RAUBASINE

YOHIMBINE, C-

, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-

16,17-Didehydro-19alpha-methyloxayohimban-16-carboxylic acid methyl ester

16,17-Didehydro-19-methyloxayohimban-16-carboxylic acid methyl ester

16,17-didehydro-19-methyloxayohimban-16-carboxylicacidmethylester

19-Epiajmalicine

4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine, oxayohimban-16-carboxylic acid deriv.

Ajmalicin

Alkaloid C

Alkaloid F

Alkaloid II

substanceii

Tensyl

Tetrahydroserpentine

Vincain

Vincein

Vinceine

Vinceinen

D-YOHIMBINE

ALPHA-YOHIMBIN

AJMALICINE

AJMALICINE(-YOHIMBINE)

AJMALICINE HCl(RG)

Ajmalicine (base and/or unspecified salts)

(19alpha)-16,17-Didehydro-19-methyloxayohimban-16-carboxylic acid methyl ester

Vincaine

(19α)-16,17-Didehydro-19-Methyl-oxayohiMban-16-carboxylic Acid Methyl Ester

NSC 72133

NSC 95087

TETRAHYDROALSTONINE; AJMALICINE

alkaloidc

alkaloidf

alkaloidii

Circolene

delta-Yohimbine

gamma-Yohimbine

Hydrosarpan

Isoarteril

Lamuran

Methyl 19-methyl-16,17-didehydrooxayohimban-16-carboxylate

Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19alpha)-

oxayohimban-16-carboxylicacid,16,17-didehydro-19-methyl-,methylester,(19

Py-tetrahydroserpentine

Ranitol

Raubaserp

Raubasil

Raumalina

Rauvasan

Sarpan

Substance II

Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methylester, (19a)-

Raubasine USP/EP/BP

(4S,4aR,13bS,14aS)-Methyl 4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate

Vinceine (Raubasine)

Ajmalicine pure, 98%

Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19α)-