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Tariquidar

Product Name
Tariquidar
CAS No.
206873-63-4
Chemical Name
Tariquidar
Synonyms
Xr9576;CS-678;XL9576;D06008;Xr 9576;Tariquidar;Unii-J58862dtvd;XL9576 Free base;Tariquidar, >=98%;Tariquidar(XR9576)
CBNumber
CB71456926
Molecular Formula
C38H38N4O6
Formula Weight
646.73
MOL File
206873-63-4.mol
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Tariquidar Property

Melting point:
>190oC (dec.)
Boiling point:
716.0±60.0 °C(Predicted)
Density 
1.276±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
10.67±0.70(Predicted)
color 
white to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1790
Product name
Tariquidar
Purity
≥98% (HPLC)
Packaging
5MG
Price
$135
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1790
Product name
Tariquidar
Purity
≥98% (HPLC)
Packaging
25MG
Price
$542
Updated
2023/06/20
Cayman Chemical
Product number
24180
Product name
Tariquidar
Purity
≥95%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
24180
Product name
Tariquidar
Purity
≥95%
Packaging
10mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
24180
Product name
Tariquidar
Purity
≥95%
Packaging
25mg
Price
$264
Updated
2024/03/01
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Tariquidar Chemical Properties,Usage,Production

Description

Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine and paclitaxel in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug sensitive cell levels (EC50 = 487 nM). Tariquidar also enhances the distribution of its substrates, increasing the amount of substrate entering the CNS. When administered at doses of 2 and 6.25 mg/kg in mice in combination with the peripherally-restricted opioid loperamide, the latency to paw withdrawal in a hot plate assay increases, indicating that loperamide is transported into the CNS.

Uses

Tariquidar is a p-glycoprotein drug efflux pump inhibitor. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both.Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer.

Definition

ChEBI: Tariquidar is a member of benzamides.

Biochem/physiol Actions

Specific inhibitor of MDR-1 (P-gp)

target

P-glycoprotein

Tariquidar Preparation Products And Raw materials

Raw materials

Preparation Products

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Tariquidar Suppliers

Canada 1 China 138 India 4 United Kingdom 2 United States 19 Global 164
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Tariquidar manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Tariquidar 206873-63-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tariquidar 206873-63-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tariquidar 206873-63-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

206873-63-4, TariquidarRelated Search:

Diphenyldiethoxysilane XR9576 AC480 (BMS-599626) ISOXADIFEN-ETHYL PHENYL VALERATE p-(2-Methoxyethyl) phenol Diphenyldimethoxysilane Ethyl acetate Ethyl acrylate Ethyl formate Ethanol Ethylparaben 4-Methoxyphenylacetone Isoquinoline Methoxydiethylborane PHENYL RESIN 4-[2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)ETHYL]-BENZENAMINE Tariquidar

  • N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxy-phenyl]quinoline-3-carboxamide
  • Tariquidar
  • 3-Quinolinecarboxamide, N-(2-(((4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)amino)carbonyl)-4,5-dimethoxyphenyl)-
  • N-(2-((4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide
  • Unii-J58862dtvd
  • Xr 9576
  • Xr9576
  • N-[2-[N-[4-[2-(6,7-DiMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl]carbaMoyl]-4,5-diMethoxyphenyl]quinoline-3-carboxaMide
  • Tariquidar(XR9576)
  • N-[2-[[[4-[2-(3,4-Dihydro-6,7-diMethoxy-isoquinolin-2(1H)-yl)ethyl]phenyl]aMino]carbonyl]-4,5-diMethoxyphenyl]-3-quinolinecarboxaMide
  • N-[2-({4-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}carbaMoyl)-4,5-diMethoxyphenyl]quinoline-3-carboxaMide
  • CS-678
  • N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide Tariquidar
  • Tariquidar N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide
  • Tariquidar, >=98%
  • XL9576 Free base
  • XL9576
  • D06008
  • XR 9576;XR-9576;D06008
  • Tariquidar USP/EP/BP
  • 206873-63-4
  • C38H38N4O6
  • Inhibitors
  • Anti-cancer&immunity
  • Inhibitor