ChemicalBook > CAS DataBase List > Tariquidar

Tariquidar

Product Name
Tariquidar
CAS No.
206873-63-4
Chemical Name
Tariquidar
Synonyms
Xr9576;CS-678;XL9576;D06008;Xr 9576;Tariquidar;Unii-J58862dtvd;XL9576 Free base;Tariquidar, >=98%;Tariquidar(XR9576)
CBNumber
CB71456926
Molecular Formula
C38H38N4O6
Formula Weight
646.73
MOL File
206873-63-4.mol
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Tariquidar Property

Melting point:
>190oC (dec.)
Boiling point:
716.0±60.0 °C(Predicted)
Density 
1.276±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
10.67±0.70(Predicted)
color 
white to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1790
Product name
Tariquidar
Purity
≥98% (HPLC)
Packaging
5MG
Price
$135
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1790
Product name
Tariquidar
Purity
≥98% (HPLC)
Packaging
25MG
Price
$542
Updated
2023/06/20
Cayman Chemical
Product number
24180
Product name
Tariquidar
Purity
≥95%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
24180
Product name
Tariquidar
Purity
≥95%
Packaging
10mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
24180
Product name
Tariquidar
Purity
≥95%
Packaging
25mg
Price
$264
Updated
2024/03/01
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Tariquidar Chemical Properties,Usage,Production

Description

Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine and paclitaxel in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug sensitive cell levels (EC50 = 487 nM). Tariquidar also enhances the distribution of its substrates, increasing the amount of substrate entering the CNS. When administered at doses of 2 and 6.25 mg/kg in mice in combination with the peripherally-restricted opioid loperamide, the latency to paw withdrawal in a hot plate assay increases, indicating that loperamide is transported into the CNS.

Uses

Tariquidar is a p-glycoprotein drug efflux pump inhibitor. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both.Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer

Uses

Tariquidar is a p-glycoprotein drug efflux pump inhibitor. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both.Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer.

Definition

ChEBI: Tariquidar is a member of benzamides.

Biochem/physiol Actions

Specific inhibitor of MDR-1 (P-gp)

target

P-glycoprotein

Tariquidar Preparation Products And Raw materials

Raw materials

Preparation Products

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Tariquidar Suppliers

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View Lastest Price from Tariquidar manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Tariquidar 206873-63-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tariquidar 206873-63-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tariquidar 206873-63-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

206873-63-4, TariquidarRelated Search:

Diphenyldiethoxysilane XR9576 AC480 (BMS-599626) ISOXADIFEN-ETHYL PHENYL VALERATE p-(2-Methoxyethyl) phenol Diphenyldimethoxysilane Ethyl acetate Ethyl acrylate Ethyl formate Ethanol Ethylparaben 4-Methoxyphenylacetone Isoquinoline Methoxydiethylborane PHENYL RESIN 4-[2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)ETHYL]-BENZENAMINE Tariquidar

  • N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxy-phenyl]quinoline-3-carboxamide
  • Tariquidar
  • 3-Quinolinecarboxamide, N-(2-(((4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)amino)carbonyl)-4,5-dimethoxyphenyl)-
  • N-(2-((4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide
  • Unii-J58862dtvd
  • Xr 9576
  • Xr9576
  • N-[2-[N-[4-[2-(6,7-DiMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl]carbaMoyl]-4,5-diMethoxyphenyl]quinoline-3-carboxaMide
  • Tariquidar(XR9576)
  • N-[2-[[[4-[2-(3,4-Dihydro-6,7-diMethoxy-isoquinolin-2(1H)-yl)ethyl]phenyl]aMino]carbonyl]-4,5-diMethoxyphenyl]-3-quinolinecarboxaMide
  • N-[2-({4-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}carbaMoyl)-4,5-diMethoxyphenyl]quinoline-3-carboxaMide
  • CS-678
  • N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide Tariquidar
  • Tariquidar N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide
  • Tariquidar, >=98%
  • XL9576 Free base
  • XL9576
  • D06008
  • XR 9576;XR-9576;D06008
  • Tariquidar USP/EP/BP
  • 206873-63-4
  • C38H38N4O6
  • Inhibitors
  • Anti-cancer&immunity
  • Inhibitor