ChemicalBook > CAS DataBase List > N-BOC-(METHYLAMINO)ACETALDEHYDE

N-BOC-(METHYLAMINO)ACETALDEHYDE

Product Name
N-BOC-(METHYLAMINO)ACETALDEHYDE
CAS No.
123387-72-4
Chemical Name
N-BOC-(METHYLAMINO)ACETALDEHYDE
Synonyms
N-Boc-(methyL;Macitentan Impurity 51;N-BOC-(METHYLAMINO)ACETALDEHYDE;N-Boc-2-(methylamino)acetaldehyde;ert-butylN-methyl-N-(2-oxoethyl)carbamate;tert-Butyl N-methyl-N-(2-oxoethyl)carbamate;O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate;N-tert-Butoxycarbonyl-(methylamino)acetaldehyde;N-methyl-N-(2-oxoethyl)-, 1,1-dimethylethyl ester;N-(tert-butoxycarbonyl)-N-MethylaMinoacetaldehyde
CBNumber
CB71480019
Molecular Formula
C8H15NO3
Formula Weight
173.21
MOL File
123387-72-4.mol
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N-BOC-(METHYLAMINO)ACETALDEHYDE Property

Boiling point:
218.2±19.0 °C(Predicted)
Density 
1.026g/ml
refractive index 
1.44
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
clear liquid
pka
-1.63±0.70(Predicted)
color 
Colorless to Light yellow
Water Solubility 
Slightly miscible with water.
Sensitive 
Air Sensitive
InChI
InChI=1S/C8H15NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h6H,5H2,1-4H3
InChIKey
MSWTVSDFEYSRMQ-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)N(C)CC=O
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5825
Product name
N-tert-Butoxycarbonyl-(methylamino)acetaldehyde
Purity
>96.0%(GC)
Packaging
1g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
B5825
Product name
N-tert-Butoxycarbonyl-(methylamino)acetaldehyde
Purity
>96.0%(GC)
Packaging
5g
Price
$126
Updated
2025/07/31
TRC
Product number
B656860
Product name
N-Boc-(Methylamino)acetaldehyde
Packaging
2.5g
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-B0863
Product name
tert-Butylmethyl(2-oxoethyl)carbamate
Purity
98.44%
Packaging
5g
Price
$71
Updated
2021/12/16
ChemScene
Product number
CS-B0863
Product name
tert-Butylmethyl(2-oxoethyl)carbamate
Purity
98.44%
Packaging
10g
Price
$124
Updated
2021/12/16
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N-BOC-(METHYLAMINO)ACETALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

N-Boc-(methylamino)acetaldehyde is involved in the preparation of benzo[d]imidazole inhibitor of co-activator associated arginine methyltransferase.

Synthesis

57561-39-4

123387-72-4

General procedure for the synthesis of N-Boc-(methylamino)acetaldehyde from N-BOC-N-methylaminoethanol: (a) Dess-Martin periodontane (22 g, 52 mmol) was added batchwise to a solution of 2-(N-Boc-methylamino)ethanol (8.8 g, 50 mmol) dissolved in dichloromethane at 0 °C. The reaction mixture was naturally warmed to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution and sodium thiosulfate solution were added and stirring was continued for 0.5 hours. Subsequently, the organic phase was separated, washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate, and concentrated to give 9 g (quantitative yield) of the title compound N-Boc-(methylamino)acetaldehyde. The product was analyzed by GC-MS and showed m/z 174 (M + 1).

References

[1] Patent: WO2007/120098, 2007, A1. Location in patent: Page/Page column 88
[2] Patent: WO2013/68552, 2013, A1. Location in patent: Page/Page column 53
[3] ChemMedChem, 2015, vol. 10, # 3, p. 470 - 489
[4] Patent: WO2011/133039, 2011, A2. Location in patent: Page/Page column 202
[5] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 21, p. 3219 - 3225

N-BOC-(METHYLAMINO)ACETALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-(METHYLAMINO)ACETALDEHYDE Suppliers

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Sci General Material & Chemical Ltd
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View Lastest Price from N-BOC-(METHYLAMINO)ACETALDEHYDE manufacturers

Career Henan Chemical Co
Product
tert-butyl N-methyl-N-(2-oxoethyl)carbamate 123387-72-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

123387-72-4, N-BOC-(METHYLAMINO)ACETALDEHYDERelated Search:

Boc-Hyp-OH BOC-L-Proline BOC-HYP(BZL)-OH BOC-3,4-DEHYDRO-PRO-OH BOC-PRO-OSU Boc-N-Me-Val-OH Boc-N-methyl-L-phenylalanine Boc-N-methyl-L-leucine N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine BOC-N-Methyl-L-alanine BOC-SAR-OH Boc-N-Methyl-L-phenylglycine BOC-N-ME-ALLO-ILE-OH BOC-PRO-PRO-OH BOC-N-ME-P-NITRO-PHE-OH DCHA BOC-N-ME-GLU(OBZL)-OH BOC-N-ME-TYR(2,6-DICHLORO-BZL)-OH BOC-PRO-LEU-VAL-OME

  • tert-Butyl N-methyl-N-(2-oxoethyl)carbamate
  • N-(tert-butoxycarbonyl)-N-MethylaMinoacetaldehyde
  • N-Boc-2-(methylamino)acetaldehyde
  • CARBAMIC ACID,N-METHYL-N-(2-OXOETHYL)-, 1,1-DIMETHYLETHYL ESTER
  • N-BOC-(METHYLAMINO)ACETALDEHYDE
  • N-methyl-N-(2-oxoethyl)-, 1,1-dimethylethyl ester
  • O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate
  • N-tert-Butoxycarbonyl-(methylamino)acetaldehyde
  • N-Boc-(methyL
  • ert-butylN-methyl-N-(2-oxoethyl)carbamate
  • 1,1-Dimethylethyl N-methyl-N-(2-oxoethyl)carbamate
  • Macitentan Impurity 51
  • 123387-72-4
  • Indolines ,Indoles