4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

Product Name: 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
CAS No.: 788136-89-0
Chemical Name: 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
Synonyms: Gefitinib analog III;Gefitinib IMpurity VIII;Gefitinib Intermediate 6;Gefitinib interMediate VI;4-((3-Chloro-4-fluorophenyl);-7-methoxyquinazolin-6-yl acetate;O-Desmorpholinopropyl Gefitinib Acetate;4-(3-Chloro-4-fluorophenylamino)-7-methoxyquizolin-6-yl acetate;4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl ac...;4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
CBNumber: CB71503974
Molecular Formula: C17H13ClFN3O3
Formula Weight: 361.75
MOL File: 788136-89-0.mol

More

Less

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate Property

Boiling point:: 471.5±45.0 °C(Predicted)
Density: 1.425
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.22±0.30(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 091222
Product name: 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
Purity: 95+%
Packaging: 250mg
Price: $521
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0037425
Product name: 4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-METHOXY-6-QUINAZOLINOL 6-ACETATE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

Matrix Scientific

Product number: 091222
Product name: 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
Purity: 95+%
Packaging: 1g
Price: $1143
Updated: 2021/12/16

Arctom

Product number: AS097578
Product name: 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate
Purity: 95%
Packaging: 250mg
Price: $6
Updated: 2021/12/16

Arctom

Product number: AS097578
Product name: 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate
Purity: 95%
Packaging: 1g
Price: $13
Updated: 2021/12/16

More

Less

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate Chemical Properties,Usage,Production

Uses

4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl Acetate, is an impurity of Gefitinib (G304000), an antineoplastic.

Synthesis

367-21-5

230955-75-6

788136-89-0

General procedure for the synthesis of 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol acetate from 3-chloro-4-fluoroaniline and 6-acetoxy-4-chloro-7-methoxyquinazoline: at 65°C, AuCl (4.2 g, 18 mmol), 6-acetoxy-4-chloro-7-methoxyquinazoline (12.6 g, 50 mmol) and 3-chloro-4-fluoroaniline (12.3 g, 85 mmol) were dissolved in 50 mL of methanol for substitution reaction. After completion of the reaction, the reaction mixture was filtered. The filtrate was concentrated and washed with petroleum ether to afford 16.9 g of the intermediate 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol acetate in 93.4% yield and 99.91% purity.

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 2, p. 870 - 879
[2] Patent: CN105693630, 2016, A. Location in patent: Paragraph 0033
[3] Patent: CN106045980, 2016, A. Location in patent: Paragraph 0024; 0025; 0026
[4] Patent: CN108047209, 2018, A. Location in patent: Paragraph 0041; 0047; 0048
[5] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00195

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate Suppliers

China 77 India 3 United States 9 Global 89

Chengdu Green Young Biomedical Technology Co., Ltd.

Tel: 86+28-85337952 18081025021
Fax: 86+28-85337952
Email: greenyoung@glykj.com
Country: China
ProdList: 94
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax: +86 (20) 39218032
Country: China
ProdList: 454
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Nanjing First Pharmaceutical Co., Ltd.

Tel: 025-83172655 13585105703
Fax: +86-25-86501191
Email: sales@njfirstpharm.com
Country: China
ProdList: 110
Advantage: 60

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

FarmaSino Pharmaceuticals (Anhui) Co.,Ltd.

Tel: +86-18512541987
Fax: 0555-5963572
Email: hll@farmasino.com
Country: China
ProdList: 241
Advantage: 60

More

Less

View Lastest Price from 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate 788136-89-0
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-25

Nanjing Fred Technology Co., Ltd

Product: 4-(3-Chloro-4-fluorophenyl-ami-no)-7-methoxyquinazolin-6-yl acetate 788136-89-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%(HPLC)
Supply Ability: 5000kg
Release date: 2023-12-13

Career Henan Chemical Co

Product: 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate 788136-89-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-16

788136-89-0, 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetateRelated Search:

Glycine Iminodiacetic acid Nitrilotriacetic acid Cellulose acetate Ammonium acetate Vinyl acetate 2-Methoxyethanol Ethyl acetate Goserelin acetate Ethyl 3-aminopropanoate hydrochloride Butyl acetate Ethyl methoxyacetate Sodium acetate Methoxyacetic acid Benzyl acetate 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol Magnesium acetate 4-(3-Chloropropyl)morpholine

4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol 6-acetate

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, 6-acetate

Gefitinib interMediate VI

Gefitinib IMpurity VIII

acetic acid [4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl] ester

4-((3-Chloro-4-fluorophenyl)

-7-methoxyquinazolin-6-yl acetate

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquizolin-6-yl acetate

6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, 6-aceta

O-Desmorpholinopropyl Gefitinib Acetate

Gefitinib Intermediate 6

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl ac...

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

Gefitinib analog III

788136-89-0

C17H13ClFN3O3

C18H15ClFN3O3