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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE

Product Name
1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
CAS No.
197638-83-8
Chemical Name
1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
Synonyms
BUTTPARK 98\06-98;1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE;4-(N-BOC-PIPERAZIN-1-YL)BENZALDEHYDE;1-boc-4-(4-formylphenyl)piperazine,97%;4-Piperazin-1-ylbenzaldehyde, N4-BOC protected;4-(4-TERT-BUTOXYCARBONYL)PIPERAZINEBENZALDEHYDE;TERT-BUTYL 4-(4'-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLATE;1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE ISO 9001：2015 REACH;1,1-Dimethylethyl 4-(4-formylphenyl)-1-piperazinecarboxylate;4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber
CB7157734
Molecular Formula
C16H22N2O3
Formula Weight
290.36
MOL File
197638-83-8.mol
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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Property

Melting point:
118-121 °C (lit.)
Boiling point:
441.4±40.0 °C(Predicted)
Density 
1.154±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
2.45±0.10(Predicted)
Appearance
Light yellow to yellow Solid
Sensitive 
Air Sensitive
InChI
InChI=1S/C16H22N2O3/c1-16(2,3)21-15(20)18-10-8-17(9-11-18)14-6-4-13(12-19)5-7-14/h4-7,12H,8-11H2,1-3H3
InChIKey
KHORERZDMJTBMR-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(C=O)C=C2)CC1
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Safety

Hazard Codes 
T
Risk Statements 
25-43
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
651427
Product name
1-Boc-4-(4-formylphenyl)piperazine
Purity
97%
Packaging
1g
Price
$73.1
Updated
2023/06/20
Sigma-Aldrich
Product number
651427
Product name
1-Boc-4-(4-formylphenyl)piperazine
Purity
97%
Packaging
5g
Price
$240
Updated
2023/06/20
TRC
Product number
B655953
Product name
1-Boc-4-(4-formylphenyl)piperazine
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR14490
Product name
4-Piperazin-1-ylbenzaldehyde,N4-BOCprotected
Packaging
1g
Price
$93
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142626
Product name
tert-Butyl 4-(4-formylphenyl)piperazine-1-carboxylate
Packaging
5G
Price
$101
Updated
2021/12/16
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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Chemical Properties,Usage,Production

Synthesis

459-57-4

57260-71-6

197638-83-8

Step 1: Anhydrous potassium carbonate (8.5 g, 62 mmol) was added to a solution of N-methyl-2-pyrrolidinone (NMP, 30 mL) containing p-fluorobenzaldehyde (3.9 g, 31 mmol) and N-BOC-piperazine (6.3 g, 34 mmol) under nitrogen protection. The reaction mixture was stirred at 135 °C for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was slowly poured into ice water (100 mL) and a yellow solid was precipitated. The precipitate was collected by filtration and washed three times (20 mL each) with cold water and dried under vacuum to give 1-BOC-4-(4-formylphenyl)piperazine as a yellow solid (6.4 g, 72% yield).

References

[1] Patent: WO2016/57779, 2016, A2. Location in patent: Page/Page column 68
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2747 - 2759
[3] Chemical Communications, 2016, vol. 52, # 67, p. 10289 - 10292
[4] Patent: WO2008/154642, 2008, A2. Location in patent: Page/Page column 155-156
[5] Patent: US2003/13737, 2003, A1

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

4-Fluorophenylacetonitrile Diisobutylaluminium hydride Toluene Potassium carbonate Chloroform Methanol Dimethyl sulfoxide 1-BOC-Piperazine Diisopropyl ether

Preparation Products

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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Suppliers

Belgium 1 China 76 Germany 2 India 2 Switzerland 1 United Kingdom 7 United States 13 Global 102
Carbosynth
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
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Apollo Scientific Ltd.
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sales@apolloscientific.co.uk
Country
United Kingdom
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6084
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CARBONE SCIENTIFIC CO.,LTD
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sales@carbonesci.com
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United Kingdom
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ETA SCIENTIFIC Co.,Ltd
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sales@etascientific.com
Country
United Kingdom
ProdList
6090
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UK GREEN SCIENTIFIC CO.,LIMITED
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sales@gs-chem.com
Country
United Kingdom
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6098
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Fulcrum Scientific Ltd.
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United Kingdom
ProdList
6565
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Butt Park Ltd.
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Email
113707.50@compuserve.com
Country
United Kingdom
ProdList
6078
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View Lastest Price from 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE manufacturers

Dideu Industries Group Limited
Product
1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 197638-83-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-23
Career Henan Chemical Co
Product
1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 197638-83-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02

197638-83-8, 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINERelated Search:

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 1-Boc-4-(2-formylphenyl)piperazine 1-Boc-4-(4-methoxycarbonylphenyl)piperazine 4-(BOC-PIPERAZIN-1-YL)-3-NITROBENZOIC A& 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE TERT-BUTYL 4-(4-CARBAMOYLPHENYL)PIPERAZINE-1-CARBOXYLATE 4-(4-ETHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(1-OXO-INDAN-5-YL)-PIPERAZINE

  • 4-(4-TERT-BUTOXYCARBONYL)PIPERAZINEBENZALDEHYDE
  • 4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 4-(N-BOC-PIPERAZIN-1-YL)BENZALDEHYDE
  • 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
  • 1-(4-FORMYL-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
  • BUTTPARK 98\06-98
  • TERT-BUTYL 4-(4'-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLATE
  • TERT-BUTYL 4-(4-FORMYLPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
  • 4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%
  • 4-Piperazin-1-ylbenzaldehyde, N4-BOC protected
  • 4-(N-Boc-piperazin-1-yl)benzaldehyde, tert-Butyl 4-(4μ-formylphenyl)piperazine-1-carboxylate
  • 1-boc-4-(4-formylphenyl)piperazine,97%
  • 4-(4-formylphenyl)-2-piperazinecarboxylic acid tert-butyl ester
  • 1-Piperazinecarboxylic acid, 4-(4-formylphenyl)-, 1,1-dimethylethyl ester
  • 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE ISO 9001：2015 REACH
  • 1,1-Dimethylethyl 4-(4-formylphenyl)-1-piperazinecarboxylate
  • 197638-83-8
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