ChemicalBook > CAS DataBase List > 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine

1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine

Product Name
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine
CAS No.
4271-96-9
Chemical Name
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine
Synonyms
DMTHPM;Pyrantel Impurity D;1,2-Dimethyl-1,4,5,6;Phenytoin Impurity 12;-1,4,5,6-tetrahydropyrimidine;Pyrantel impurity D (Y0001817);Pyrantel embonate EP Impurity D;1,2-dimethyl-5,6-dihydro-4H-pyrimidine;1,2-Dimethyl-1,4,5,6-terahydropyrimidine;1,2-Dimethyl-1,4,5,6-Tetrahydropyrimidne
CBNumber
CB7164640
Molecular Formula
C6H12N2
Formula Weight
112.17
MOL File
4271-96-9.mol
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1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Property

Boiling point:
125°C (115 mmHg)
Density 
0,98 g/cm3
Flash point:
73°C
storage temp. 
2-8°C
solubility 
Acetone (Sparingly), Chloroform (Sparingly), DMSO (Sparingly), Methanol(Sparingly)
pka
13.42±0.20(Predicted)
form 
Oil
color 
Clear Colourless
Specific Gravity
0.982 (20/4℃)
CAS DataBase Reference
4271-96-9(CAS DataBase Reference)
EPA Substance Registry System
Pyrimidine, 1,4,5,6-tetrahydro-1,2-dimethyl- (4271-96-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
22-34
Safety Statements 
23-26-36/37/39
RIDADR 
3267
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001817
Product name
Pyrantel impurity D
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
20 mg
Price
$164
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR2084
Product name
Pyrantel Impurity D
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50mg
Price
$330
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001817
Product name
Pyrantel impurity D
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001817
Price
$151
Updated
2023/01/07
TRC
Product number
D440120
Product name
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine
Packaging
25g
Price
$185
Updated
2021/12/16
TRC
Product number
D440120
Product name
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine
Packaging
250g
Price
$485
Updated
2021/12/16
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1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Chemical Properties,Usage,Production

Uses

1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine is a reagent used in the synthesis of pyrantel derivatives with nematocidal activity. Also used as a reactant in the preparation of hapten antibodies that evoke terpenoid cyclization.

Synthesis

56125-48-5

4271-96-9

General procedure for the synthesis of 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine from N-[3-(methylamino)propyl]-acetamide: N-[3-(methylamino)propyl]-acetamide obtained from the previous step was dissolved in 200 mL of polyphosphoric acid ester (PPE) and placed in a microwave reactor. The reaction temperature was controlled to be 80 °C and the reaction time was 2 hours. After completion of the reaction, the reaction mixture was purified to afford the target product 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine 240 g in 94.42% yield.

References

[1] Patent: CN108822044, 2018, A. Location in patent: Paragraph 0025; 0028; 0031; 0032; 0037; 0042; 0047-0057

1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Preparation Products And Raw materials

Raw materials

1,2-Diaminopropane 3-Aminopropionitrile

Preparation Products

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View Lastest Price from 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine 4271-96-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Career Henan Chemical Co
Product
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine 4271-96-9
Price
US $8.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-15

4271-96-9, 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidineRelated Search:

Dimethyl sulfone Dimethyl fumarate Dacthal Xylene Poly(dimethylsiloxane) Dimethyl sulfoxide N,N-Dimethylformamide 1,3-Dimethylbarbituric acid Dimethyl carbonate N,N-Dimethylaniline Dimethyl sulfate Dimethyl ether ETHANE Dimethyl phthalate N,N-Dimethylacetamide 1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE HYDROTRIBROMIDE 1,5-Diazabicyclo[4.3.0]non-5-ene MORANTEL CITRATE MONOHYDRATE

  • 1,4,5,6-tetrahydro-1,2-dimethyl-pyrimidin
  • Pyrimidine,1,4,5,6-tetrahydro-1,2-dimethyl-
  • DMTHPM
  • 1,2-DIMETHYL-1,4,5,6-TETRAHYDROPYRIMIDINE
  • 1,4,5,6-TETRAHYDRO-1,2-DIMETHYLPYRIMIDINE
  • 1,2-Dimethyl-1,4,5,6-Tetrahydropyrimidne
  • Two-1,4,5,6- four1,2-MethylhydrogenpyriMidine
  • 1,2-Dimethyl-1,4,5,6-terahydropyrimidine
  • 1,2-dimethyl-5,6-dihydro-4H-pyrimidine
  • 1,2-Dimethyl-1,4,5,6
  • Pyrantel Impurity D
  • -1,4,5,6-tetrahydropyrimidine
  • Di- Methyl Tetra Hydro Pyrimidine (DMTHP)
  • Morantel hydrogen tartrate EP Impurity C
  • Pyrantel embonate EP Impurity D
  • Pyrantel impurity D (Y0001817)
  • Phenytoin Impurity 12
  • 4271-96-9
  • 4171-96-9
  • Heterocyclic Compounds
  • Boron, Nitrile, Thio,& TM-Cpds