GSK-CXCR2

ChemicalBook > CAS DataBase List > GSK-CXCR2

Product Name: GSK-CXCR2
CAS No.: 211096-49-0
Chemical Name: GSK-CXCR2
Synonyms: GSK-CXCR2;SB 265610;SB265610 >=98% (HPLC);N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea;Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-;1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea;CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
CBNumber: CB71872298
Molecular Formula: C14H9BrN6O
Formula Weight: 357.16
MOL File: 211096-49-0.mol

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GSK-CXCR2 Property

Boiling point:: 527.0±45.0 °C(Predicted)
Density: 1.77±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
pka: 6.13±0.40(Predicted)
color: white to light brown

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0421
Product name: SB265610
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $160
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0421
Product name: SB265610
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $642
Updated: 2024/03/01

Cayman Chemical

Product number: 17879
Product name: SB 265610
Purity: ≥98%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 17879
Product name: SB 265610
Purity: ≥98%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 17879
Product name: SB 265610
Purity: ≥98%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

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GSK-CXCR2 Chemical Properties,Usage,Production

Uses

SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.

Biological Activity

Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .

Biochem/physiol Actions

SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.

storage

Store at RT

GSK-CXCR2 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-CXCR2 Suppliers

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211096-49-0, GSK-CXCR2Related Search:

Sb-742457 SBI-0206965 SB9200 SBI-993 SB-649868 SB1317 SB 203580 SB 204741 SB1317 GSK-CXCR2 N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA SB242235 SB 225002 (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE SB 297006 SB 239063 Benzamide, N-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-4-nitro-, hydrochloride (1:1) SB 200646 HYDROCHLORIDE

GSK-CXCR2

N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea

SB 265610

1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea

Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-

SB265610 >=98% (HPLC)

CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors

211096-49-0

C14H9BrN6O