ChemicalBook > CAS DataBase List > GSK-CXCR2
GSK-CXCR2
- Product Name
- GSK-CXCR2
- CAS No.
- 211096-49-0
- Chemical Name
- GSK-CXCR2
- Synonyms
- GSK-CXCR2;SB 265610;SB265610 >=98% (HPLC);N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea;Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-;1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea;CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
- CBNumber
- CB71872298
- Molecular Formula
- C14H9BrN6O
- Formula Weight
- 357.16
- MOL File
- 211096-49-0.mol
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GSK-CXCR2 Property
- Boiling point:
- 527.0±45.0 °C(Predicted)
- Density
- 1.77±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 6.13±0.40(Predicted)
- color
- white to light brown
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0421
- Product name
- SB265610
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $160
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0421
- Product name
- SB265610
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $642
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17879
- Product name
- SB 265610
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $97
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17879
- Product name
- SB 265610
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17879
- Product name
- SB 265610
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $223
- Updated
- 2024/03/01
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GSK-CXCR2 Chemical Properties,Usage,Production
Uses
SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.
Biological Activity
Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
Biochem/physiol Actions
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
storage
Store at RT
GSK-CXCR2 Preparation Products And Raw materials
Raw materials
Preparation Products
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