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TYROTHRICIN

History

Product Name: TYROTHRICIN
CAS No.: 1404-88-2
Chemical Name: TYROTHRICIN
Synonyms: dermotricine;tyri10;coltirot;tyroderm;martricin;solutricine;soluthricin;bactratycin;TYROTHRICIN;hydrotricine
CBNumber: CB7196704
Molecular Formula: C6H13NO5
Formula Weight: 179.17112
MOL File: 1404-88-2.mol

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TYROTHRICIN Property

storage temp.: Store at -20°C
solubility: Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
form: Solid
color: White to off-white
EPA Substance Registry System: Tyrothricin (1404-88-2)

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Safety

Safety Statements: 22-24/25
WGK Germany: 2
RTECS: YP2975000
Toxicity: LD50 in mice (mg/kg): >1500 s.c.; 100 i.p.; >3000 orally (Sous)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3000000
Product name: Tyrothricin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 20 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: T3000000
Product name: Tyrothricin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: t3000000
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 22177
Product name: Tyrothricin
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 22177
Product name: Tyrothricin
Purity: ≥95%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 22177
Product name: Tyrothricin
Purity: ≥95%
Packaging: 10mg
Price: $131
Updated: 2024/03/01

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TYROTHRICIN Chemical Properties,Usage,Production

History

At the Rockefeller Institute in New York in 1939, Rene Dubos isolated a bactericidal, proteinfree extract from Bacillus brevis.11 This material, tyrothricin, was soon shown to consist mainly of a cyclic decapeptide called tyrocidin, together with a similar compound called gramicidin S, which was 50 times as potent.12 Their structures were elucidated by Richard Synge at the Lister Institute in London using paper chromatography in one of its earliest applications.13,14 Although both components were able to protect mice against pneumococci, they were too toxic for general use.

Tyrothricin was suitable only for topical application. It was marketed in the USA by Sharp & Dohme in 1942 for treatment of Gram-positive infections. Since then, it has been universally used in throat lozenges as a non-prescription antibiotic, but the commercial success of this type of product has been largely due to the incorporation of benzocaine, a topical anaesthetic that soothes sore throats.

Chemical Properties

White or almost white powder.

Uses

Tyrothricin is a complex of two unrelated peptide families, gramicidin complex and tyrocidines complex, produced by Bacillus brevis and discovered by Dubos in 1939. Typically, tyrothricin is composed of 20% of the linear pentadecylpeptide gramicidins and 80% of cyclic decapeptide tyrocidines. Both the gramicidins and tyrocidines act by disrupting bacterial cell wall integrity, but by differing mechanisms. Tyrothricin is used clinically for bacterial skin infections in some countries.

Definition

An antibiotic produced by growth of Bacillus brevis. It consists of a mixture of antibiotics, principally gramicidin and tyrocidine. Gramicidin is the more active component. Use is generally limited to local external applications. It is active against some Gram-positive bacteria, including species of pneumococci, streptococci, and staphylococci.

brand name

Bactratycin (Wallace).

in vivo

In animal models using HSV type 1, a pre-incubation of the virus suspension with Tyrothricin could significantly decrease the lethality in mice. The effect could only be shown after a direct contact between Tyrothricin and the virus^[1].
Nevertheless disruption of the integrity of eukaryotic membranes is observed at higher Tyrothricin concentrations in vitro. This effect is exemplified as hemolytic activity of Tyrothricin in in vitro studies and when applied to animals i.v.. In contrast to an intravenous (LD₅₀ mouse: 3,7 mg/kg) and an intraperitoneal (LD₅₀ mouse: 20-45 mg/kg) application the oral application is very well tolerated, as Tyrothricin is destroyed in the gastro-intestinal tract^[1].

TYROTHRICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TYROTHRICIN manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Tyrothricin 1404-88-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2025-08-30

RongNa Biotechnology Co.,Ltd

Product: Tyrothricin 1404-88-2
Price: US $1.00/g
Min. Order: 1g
Purity: 0.99
Supply Ability: 20 tons
Release date: 2025-06-02

Hebei Yanxi Chemical Co., Ltd.

Product: TYROTHRICIN 1404-88-2
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-21

1404-88-2, TYROTHRICINRelated Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) COBALT(II) ACETYLACETONATE Benzyl isocyanide Cupric acetylacetonate SALCOMINE N-BUTYLISOCYANIDE TERT-BUTYL ISOCYANIDE Ferric acetylacetonate PHENYLSELENOL Aluminum acetylacetonate METHYL ISOCYANOACETATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE

bactratycin

coltirot

dermotricine

duboscrudecrystals

hydrotricine

3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-3,22,25-tris(phenylmethyl)-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid

3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-azanyl-2-oxo-ethyl)-9-(3-azanylpropyl)-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-3,22,25-tris(phenylmethyl)-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid

intradermtyrothricin

martricin

soluthricin

solutricine

tyri10

tyroderm

TYROTHRICIN

Tyrothricine

tyrothricin from bacillus aneurinolyticus (bacillus brevis)

3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-keto-ethyl)-9-(3-aminopropyl)-3,22,25-tris(benzyl)-15-(4-hydroxybenzyl)-6-isobutyl-12-isopropyl-2,5,8,11,14,18,21,24,27-nonaketo-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propionic acid

Tyrothricin CRS

TYROTHRICIN USP/EP/BP

1404-88-2

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