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TYROTHRICIN

History
Product Name
TYROTHRICIN
CAS No.
1404-88-2
Chemical Name
TYROTHRICIN
Synonyms
dermotricine;tyri10;coltirot;tyroderm;martricin;solutricine;soluthricin;bactratycin;TYROTHRICIN;hydrotricine
CBNumber
CB7196704
Molecular Formula
C6H13NO5
Formula Weight
179.17112
MOL File
1404-88-2.mol
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TYROTHRICIN Property

storage temp. 
Store at -20°C
solubility 
Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
form 
Solid
color 
White to off-white
EPA Substance Registry System
Tyrothricin (1404-88-2)
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Safety

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
YP2975000
Toxicity
LD50 in mice (mg/kg): >1500 s.c.; 100 i.p.; >3000 orally (Sous)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3000000
Product name
Tyrothricin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
t3000000
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
22177
Product name
Tyrothricin
Purity
≥95%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
22177
Product name
Tyrothricin
Purity
≥95%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
22177
Product name
Tyrothricin
Purity
≥95%
Packaging
10mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
22177
Product name
Tyrothricin
Purity
≥95%
Packaging
25mg
Price
$204
Updated
2024/03/01
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TYROTHRICIN Chemical Properties,Usage,Production

History

At the Rockefeller Institute in New York in 1939, Rene Dubos isolated a bactericidal, proteinfree extract from Bacillus brevis.11 This material, tyrothricin, was soon shown to consist mainly of a cyclic decapeptide called tyrocidin, together with a similar compound called gramicidin S, which was 50 times as potent.12 Their structures were elucidated by Richard Synge at the Lister Institute in London using paper chromatography in one of its earliest applications.13,14 Although both components were able to protect mice against pneumococci, they were too toxic for general use.
 
Tyrothricin was suitable only for topical application. It was marketed in the USA by Sharp & Dohme in 1942 for treatment of Gram-positive infections. Since then, it has been universally used in throat lozenges as a non-prescription antibiotic, but the commercial success of this type of product has been largely due to the incorporation of benzocaine, a topical anaesthetic that soothes sore throats.

Chemical Properties

White or almost white powder.

Uses

Tyrothricin is a complex of two unrelated peptide families, gramicidin complex and tyrocidines complex, produced by Bacillus brevis and discovered by Dubos in 1939. Typically, tyrothricin is composed of 20% of the linear pentadecylpeptide gramicidins and 80% of cyclic decapeptide tyrocidines. Both the gramicidins and tyrocidines act by disrupting bacterial cell wall integrity, but by differing mechanisms. Tyrothricin is used clinically for bacterial skin infections in some countries.

Definition

An antibiotic produced by growth of Bacillus brevis. It consists of a mixture of antibiotics, principally gramicidin and tyrocidine. Gramicidin is the more active component. Use is generally limited to local external applications. It is active against some Gram-positive bacteria, including species of pneumococci, streptococci, and staphylococci.

brand name

Bactratycin (Wallace).

TYROTHRICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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TYROTHRICIN Suppliers

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View Lastest Price from TYROTHRICIN manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
TYROTHRICIN 1404-88-2
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-21
Career Henan Chemical Co
Product
TYROTHRICIN 1404-88-2
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

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