PHOSPHATIDYLETHANOLAMINE

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PHOSPHATIDYLETHANOLAMINE

Product Name: PHOSPHATIDYLETHANOLAMINE
CAS No.: 39382-08-6
Chemical Name: PHOSPHATIDYLETHANOLAMINE
Synonyms: Cephalins;L-A-PHOSPHATIDYLETHANOLAMINE TYPE III:*F ROM EGG YOL;1,2-Diacyl-sn-glycero-3-phosphoethanolamine, L-α-Cephalin;1,2-Diacyl-sn-glycero-3-phosphoethanolamine, 3-sn-Phosphatidylethanolamine, L-α-Cephalin;Kephalins;E COLI PE;Cephalinex;PE/Cephalin;l-α-cephalin;Phospholipids cephalins
CBNumber: CB7198531
Molecular Formula: C41H78NO8P
Formula Weight: 744.033681
MOL File: 39382-08-6.mol

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PHOSPHATIDYLETHANOLAMINE Property

Density: approximate 1.47g/ml(20℃)
storage temp.: -20°C
solubility: chloroform: 50 mg/mL, slightly hazy, brown-yellow
form: solution
color: Off-white to light yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22-38-40-48/20/22-67-36/38-20-63-68/20/21/22-20/21/22-20/22
Safety Statements: 36/37-26
RIDADR: UN 1888 6.1/PG 3
WGK Germany: 3
F: 1-8-10
HS Code: 2923202000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1535744
Product name: Phosphatidylethanolamine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $805
Updated: 2024/03/01

Sigma-Aldrich

Product number: 60660
Product name: 3-sn-Phosphatidylethanolamine solution
Purity: ≥97.0% (10 mg phospholipid per ml CHCl3, TLC)
Packaging: 1ml
Price: $120
Updated: 2023/06/20

Cayman Chemical

Product number: 24332
Product name: Phosphatidylethanolamines (egg)
Purity: ≥98%
Packaging: 50mg
Price: $305
Updated: 2024/03/01

Cayman Chemical

Product number: 24332
Product name: Phosphatidylethanolamines (egg)
Purity: ≥98%
Packaging: 100mg
Price: $578
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001953
Product name: Phosphatidylethanolamine from soya bean
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001953
Price: $156
Updated: 2024/03/01

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PHOSPHATIDYLETHANOLAMINE Chemical Properties,Usage,Production

Uses

L-α-Phosphatidylethanolamine from egg yolk has been used:

as a component of lipid mixture for the synthesis of giant unilamellar vesicles (GUVs)
in ceramide phosphoethanolamine (CPE) synthase assay using crude sphingomyelin synthase-related protein from Hela cells
for the standard curve generation for the quantification of lipids in plantaris muscle homogenates from mice

General Description

L-α-Phosphatidylethanolamine from egg yolk has high unsaturated fatty acid content and elicits radical-scavenging activity. L-α-Phosphatidylethanolamine (PE) is a membrane phospholipid and is interconverted to phosphotidylserine in the presence of phosphatidylserine synthase 2. PE is essential for maintaining the structural integrity of membranes. It is the second most abundant phospholipid in animals, plants and yeast and the major lipid in bacteria. It is synthesized in mitochondria in mammals.

Enzyme inhibitor

This hygroscopic phospholipid, also called cephalin and 1,2-diacyl-snglycero- 3-phosphoethanolamine, is an important constituent of biomembranes and lipoproteins. It is the major structural phospholipid in brain tissue. The physical properties depend on the nature of the acyl groups and on the presence of other lipids. Freshly prepared phosphatidylethanolamines are white solids that turn yellow and brown on exposure to air. They typically sinter between 80 and 90°C and melt in the neighborhood of 175°C. Solutions of phosphatidylethanolamine slowly decompose at room temperature (roughly 0.3-0.5% per day); hence, solutions should always be freshly prepared and kept cold prior to use. It is labile in alkaline conditions. See also specific compound Target(s): b- N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase; Nacetyllactosamine synthase; acylglycerol kinase, or monoacylglycerol kinase; cholesterol monooxygenase, side-chain-cleaving, or CYP11A1; chymase; cytidylate cyclase; dolichyldiphosphatase; dolichyl-phosphatase; dopamine b-monooxygenase; ethanolaminephosphotransferase; glutamate dehydrogenase; γ-glutamyl transpeptidase, mildly inhibited; glycerol-3-phosphate Oacyltransferase; glycerone-phosphate O-acyltransferase, or dihydroxyacetione-phosphate O-acyltransferase; hormone-sensitive lipase; 3-hydroxybutyrate dehydrogenase; indole-3-acetate b-glucosyltransferase; phosphatidate cytidylyltransferase; 1- phosphatidylinositol 4-kinase; phosphoinositide phospholipase C; phospholipase D, phosphatidylcholine-specific enzyme; sphingomyelin phosphodiesterase; steryl-b-glucosidase; UDP-Nacetylglucosamine: dolichyl-phosphate N-acetylglucosaminephosphotransferase.

Purification Methods

Purify the cephalin by dissolving it in EtOH, adding Pb(OAc)2.3H3O (30g in 100mL H2O) until excess Pb2+ is present. Filter off the solid. Pass CO2 gas through the solution until precipitation of PbCO3 ceases. Filter the solid off and evaporate (while bubbling CO2) under vacuum. An equal volume of H2O is added to the residual oil and extracted with hexane. The hexane extract is washed with H2O until the aqueous phase is free from Pb [test with dithizone (2 mg in 100 mL CCl4; Feigel Spot Tests Vol I, Elsevier p. 10 1954)]. The hexane is dried (Na2SO4), filtered and evaporated to give a yellow waxy solid which should be dried to constant weight in vacuo. It is practically insoluble in H2O and Me2CO, but freely soluble in CHCl3 (5%) and Et2O, and slightly soluble in EtOH. [Schofield & Dutton Biochemical Preparations 5 5 1957.]

PHOSPHATIDYLETHANOLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

4-ISOCYANOBENZOPHENONE

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39382-08-6, PHOSPHATIDYLETHANOLAMINERelated Search:

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide Cupric acetylacetonate Ethyl isocyanoacetate PHENYLSELENOL COBALT(II) ACETYLACETONATE Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) METHYL ISOCYANOACETATE N-BUTYLISOCYANIDE TERT-BUTYL ISOCYANIDE 3-sn-Phosphatidylethanolamine, 1,2-dihexadecyl, L-β,γ-Dihexadecyl-α-cephalin

1,2-Diacyl-sn-glycero-3-phosphoethanolamine, L-α-Cephalin

1,2-Diacyl-sn-glycero-3-phosphoethanolamine, 3-sn-Phosphatidylethanolamine, L-α-Cephalin

[(2R)-1-[2-azanylethoxy(hydroxy)phosphoryl]oxy-3-pentadecanoyloxy-propan-2-yl] icosanoate

arachidic acid [(1R)-1-[[2-aminoethoxy(hydroxy)phosphoryl]oxymethyl]-2-pentadecanoyloxy-ethyl] ester

PHOSPHATIDYLCHOLINE(EGG)(RG)

3-sn-Phosphatidylethanolamine solution,L-α-Cephalin

L-α-Phosphatidylethanolamine from egg yolk,1,2-Diacyl-sn-glycero-3-phosphoethanolamine, L-α-Cephalin

L-α-Phosphatidylethanolamine from Escherichia coli,1,2-Diacyl-sn-glycero-3-phosphoethanolamine, 3-sn-Phosphatidylethanolamine, L-α-Cephalin

L-α-Phosphatidylethanolamine from Glycine max (soybean),1,2-Diacyl-sn-glycero-3-phosphoethanolamine, L-α-Cephalin

3-SN-PHOSPHATIDYLETHANOLAMINE E COLI

Cephalins

L-A-PHOSPHATIDYLETHANOLAMINE TYPE V-A

L-A-PHOSPHATIDYLETHANOLAMINE TYPE III:*F ROM EGG YOL

L-A-PHOSPHATIDYLETHANOLAMINE TYPE V*FROM ESCHERICHI

3-SN-PHOSPHATIDYLETHANOLAMINE SOLUTION, FROM SOYBEAN

3-SN-PHOSPHATIDYLETHANOLAMINE FROM E. CO LI

L-A-PHOSPHATIDYLETHANOLAMINE TYPE III

L-A-PHOSPHATIDYLETHANOLAMINE TYPE IX*FRO M ESCHERICH

L-A-PHOSPHATIDYLETHANOLAMINE TYPE IV:*FR OM SOYBEAN

L-A-PHOSPHATIDYLETHANOLAMINE*TYPE VII-A FROM BOVINE

L-A-PHOSPHATIDYLETHANOLAMINE TYPE VII:*F ROM BOVINE

L-A-PHOSPHATIDYLETHANOLAMINE TYPE VII*FR OM BOVINE L

3-SN-PHOSPHATIDYLETHANOLAMINE SOLUTION, FROM EGG YOLK

L-A-PHOSPHATIDYLETHANOLAMINE TYPE III*FR OM EGG YOLK

PhosphatidylethanolamineExEgg

l-α-cephalin

l-α-phosphatidylethanolamine from egg yolk

l-α-phosphatidylethanolamine from escherichia coli

l-α-phosphatidylethanolamine from glycine max (soybean)

L-ALPHA-PHOSPHATIDYLETHANOLAMINE SOLUTION, EGG YOLK

Phosphatidylethanolamine (100 mg) (COLD SHIPMENT REQUIRED)

L-LPHA-PHOSPHATIDYLETHANOLAMINE FRO

L-A-PHOSPHATIDYLETHANOLAMINE TYPE IV

3-sn-phosphatidylethanolaminesolution

PHOSPHATIDYLETHANOLAMINE

Phosphatidylethanolamine (100 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)

Cephalinex

Glycerophospholipids cephalins

Kephalins

Phospholipids cephalins

L-3-PHOSPHATIDYLETHANOLAMINE

L-ALPHA-CEPHALIN E COLI

L-ALPHA-CEPHALIN TYPE V ESCHERICHIA COLI

L-ALPHA-PHOSPHATIDYLETHANOLAMINE TYPE V ESCHERICHIA COLI

L-A-PHOSPHATIDYLETHANOLAMINE (E COLI)

E COLI PE

1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE TYPE V ESCHERICHIA COLI

L-alpha-Phosphatidylethanolamine from Glycine max (soybean)

L-alpha-Phosphatidylethanolamine from egg yolk

Phosphatidylethanolamine from soya bean

PHOSPHATIDYLETHANOLAMINE (PE)

(18R,21S)-24-Amino-21-hydroxy-21-oxido-15-oxo-16,20,22-trioxa-21λsup5sup-phosphatetracosan-18-ylicosanoate

PHOSPHATIDYLETHANOLAMINE ISO 9001：2015 REACH

L-α-Phosphatidyleth an olamine

Phosphatidylethanolamine (chicken egg)

L-α-Phosphatidylethanolamine from egg yolk

PE/Cephalin

Phosphatidylethanolamine（from egg）