2-Chloropyridine-5-carbaldehyde

Product Name: 2-Chloropyridine-5-carbaldehyde
CAS No.: 23100-12-1
Chemical Name: 2-Chloropyridine-5-carbaldehyde
Synonyms: 6-CHLORONICOTINALDEHYDE;6-CHLORO-PYRIDINE-3-CARBALDEHYDE;TIMTEC-BB SBB004157;2-Chloropyridine-5-c;oropyridine-5-carbaL;6-Chloronicotildehyde;2-CHLORO-5-FORMYLPYRIDINE;6-Chloronicotinaldehyde 97%;6-CHLORO-PYRIDIN-3-CARBALDEHYDE;2-CHLOROPYRIDINE-5-CARBALDEHYDE
CBNumber: CB7205204
Molecular Formula: C6H4ClNO
Formula Weight: 141.56
MOL File: 23100-12-1.mol

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2-Chloropyridine-5-carbaldehyde Property

Melting point:: 77-81 °C(lit.)
Boiling point:: 117-119 °C(Press: 5 Torr)
Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: -1.85±0.10(Predicted)
form: Crystalline Powder
color: White to yellow
Water Solubility: Soluble in water.
InChI: InChI=1S/C6H4ClNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
InChIKey: AFWWKZCPPRPDQK-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=CC=C1C=O
CAS DataBase Reference: 23100-12-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 596175
Product name: 6-Chloropyridine-3-carboxaldehyde
Purity: 96%
Packaging: 1g
Price: $39.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 596175
Product name: 6-Chloropyridine-3-carboxaldehyde
Purity: 96%
Packaging: 5g
Price: $144
Updated: 2023/06/20

TCI Chemical

Product number: C2519
Product name: 6-Chloro-3-pyridinecarboxaldehyde
Purity: >96.0%(GC)
Packaging: 1g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: C2519
Product name: 6-Chloro-3-pyridinecarboxaldehyde
Purity: >96.0%(GC)
Packaging: 5g
Price: $136
Updated: 2025/07/31

TRC

Product number: C380528
Product name: 6-Chloronicotinaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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2-Chloropyridine-5-carbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Off-white crystal

Uses

2-Chloropyridine-5-carboxaldehyde is used as pharmaceutical intermediates

Synthesis

21543-49-7

23100-12-1

The general procedure for the synthesis of 6-chloropyridine-3-carbaldehyde according to Lee et al. was as follows: oxalyl chloride (3.81 g, 30.0 mmol, 3.0 equiv.) was dissolved in dry dichloromethane (35 mL) at -78 °C (dry ice/acetone bath). Dimethyl sulfoxide (DMSO, 46.9 g, 0.60 mol, 60.0 eq.) was slowly added dropwise under stirring and stirring was continued for 30 min at -78 °C. Subsequently, 2-chloro-5-hydroxymethylpyridine (1.44 g, 10.0 mmol, 1.00 eq.) was dissolved in dichloromethane (10 mL) and added slowly dropwise via syringe to the cooled reaction mixture. After the reaction mixture was stirred at -78 °C for 40 min, triethylamine (NEt3, 91.9 g, 0.90 mol, 90.0 eq.) was added at a rate of 2.0 mL/min. Stirring was continued at -78 °C for 1 hour, then brought to room temperature and stirred for 1.5 hours. After completion of the reaction, the reaction mixture was diluted with ether (60 mL) and the organic phase was washed sequentially with saturated aqueous sodium bicarbonate (2 x 30 mL), 1M aqueous potassium bisulfate (60 mL) and saturated aqueous sodium bicarbonate (30 mL). After separation of the organic phase, it was dried with anhydrous sodium sulfate, filtered to remove solids, and concentrated under reduced pressure to remove solvent. Finally, it was purified by silica gel column chromatography (n-pentane/ethyl acetate/triethylamine=200/100/6) to afford the light yellow solid product 6-chloropyridine-3-carbaldehyde (1.35 g, 96% yield).

References

[1] Chemical Communications, 1999, # 18, p. 1907 - 1908
[2] Organic Letters, 2005, vol. 7, # 14, p. 2965 - 2967
[3] Electrochimica Acta, 2014, vol. 140, p. 101 - 107
[4] Chemistry - A European Journal, 2016, vol. 22, # 15, p. 5319 - 5326
[5] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 10, p. 1253 - 1255

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View Lastest Price from 2-Chloropyridine-5-carbaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloropyridine-5-carbaldehyde 23100-12-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-23

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloropyridine-5-carbaldehyde 23100-12-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

Henan Fengda Chemical Co., Ltd

Product: 6-Chloronicotinaldehyde 23100-12-1
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

23100-12-1, 2-Chloropyridine-5-carbaldehydeRelated Search:

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6-Chloropyridine-3-carboxaldehyde≥ 98%(GC)

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2-Chloropyridine-5-carbaldehyde ISO 9001：2015 REACH

TIANFUCHEM--23100-12-1--High purity 2-Chloropyridine-5-carbaldehyde factory price

Oxazole,2-(chloromethyl)-7-methyl-

6-Chloronicotinaldehyde, 2-Chloropyridine-5-carbaldehyde, 6-Chloropyridine-3-carbaldehyde, 2-Chloro-5-formylpyridine, 6-Chloro-3-pyridinecarboxaldehyde, 2-Chloro-5-pyridinecarbaldehyde

6-Chloronicotildehyde

23100-12-1

23100-13-1

C6H4CINO

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

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C1 to C6

C5 to C6

C6 to C7

Carbonyl Compounds

Chemical Synthesis

Halogenated Heterocycles

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Organic Building Blocks

Boronic Acid

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Aldehydes

Pyridines

Heterocycle-Pyridine series

Pyridine