Ethyl isocyanoacetate

Product Name: Ethyl isocyanoacetate
CAS No.: 2999-46-4
Chemical Name: Ethyl isocyanoacetate
Synonyms: Ethyl 2-isocyanoacetate;Isocyanoacetate;2-Oxo-2-ethoxyethyl isocyanide;HANSA ISN-0528;BIO-FARMA BF001872;ethyl isocyanzacetate;ETHYL ISOCYANOACETATE;Ethylisocyanatoactate;EthylIsocyanoacetate>Ethylisocyanoacetate,98%
CBNumber: CB7209404
Molecular Formula: C5H7NO2
Formula Weight: 113.11
MOL File: 2999-46-4.mol

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Ethyl isocyanoacetate Property

Boiling point:: 194-196 °C (lit.)
Density: 1.035 g/mL at 25 °C (lit.)
vapor pressure: 61.7Pa at 25℃
refractive index: n20/D 1.418(lit.)
Flash point:: 184 °F
storage temp.: 2-8°C
solubility: Chloroform, Methanol (Slightly)
form: Liquid
color: Clear amber to dark brown
Water Solubility: Miscible with organic solvents. Slightly miscible with water.
Sensitive: Moisture & Light Sensitive
BRN: 3588613
Exposure limits: NIOSH: IDLH 25 mg/m3
LogP: 0.91 at 25℃
CAS DataBase Reference: 2999-46-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/22-20/21/22
Safety Statements: 36/37/39-26-36/37-24/25
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3
F: 8-9-21
HazardClass: 6.1
PackingGroup: III
HS Code: 29299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 226319
Product name: Ethyl isocyanoacetate
Purity: 95%
Packaging: 5g
Price: $125
Updated: 2024/03/01

Sigma-Aldrich

Product number: 226319
Product name: Ethyl isocyanoacetate
Purity: 95%
Packaging: 25g
Price: $272
Updated: 2024/03/01

TCI Chemical

Product number: I0562
Product name: Ethyl Isocyanoacetate
Purity: >97.0%(GC)
Packaging: 5g
Price: $86
Updated: 2024/03/01

TCI Chemical

Product number: I0562
Product name: Ethyl Isocyanoacetate
Purity: >97.0%(GC)
Packaging: 25g
Price: $296
Updated: 2024/03/01

Alfa Aesar

Product number: L15379
Product name: Ethyl isocyanoacetate, 98%
Packaging: 1g
Price: $36.1
Updated: 2024/03/01

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Ethyl isocyanoacetate Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brom liquid. Slightly soluble in water and lye, miscible in ethanol and ether.

Uses

Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.

Uses

Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.

Preparation

synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).

General Description

Material may darken upon storage

Ethyl isocyanoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE

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Ethyl isocyanoacetate Suppliers

Americas 1 Belgium 1 China 181 Europe 1 Germany 5 India 11 Japan 4 Poland 1 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 9 United States 24 Global 241

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View Lastest Price from Ethyl isocyanoacetate manufacturers

Hebei Fengqiang Trading Co., LTD

Product: Ethyl isocyanoacetate 2999-46-4
Price: US $100.00/drum
Min. Order: 1drum
Purity: 99
Supply Ability: 5000
Release date: 2023-08-30

Hebei Mojin Biotechnology Co., Ltd

Product: Ethyl isocyanoacetate 2999-46-4
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 20ton
Release date: 2021-10-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl isocyanoacetate 2999-46-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

2999-46-4, Ethyl isocyanoacetateRelated Search:

Ethyl cellulose Ethylparaben Ethyl methoxyacetate Ethyl acetoacetate Ethylbenzene 2-Methoxyethyl cyanoacetate Ethyl cyanoglyoxylate-2-oxime Ethyl N-cyanoethanimideate Ethyl isobutyrate METHYL ISOCYANOACETATE Tetraethyl orthosilicate Cyanoacetic acid Ethyl formate Ethyl acrylate Ethyl bromoacetate Ethanol Ethyl cyanoacetate CHLOROETHANE

Acetic acid, isocyano-, ethyl ester

Ethylisocyanoacetate,98%

Isocyanoacetate

ethyl isocyanoacetate 2999-46-4

(2-Oxo-2-ethoxyethyl) isocyanide

2-Oxo-2-ethoxyethyl isocyanide

Ethoxycarbonylmethyl isocyanide

Ethyl 2-isocyanoacetate

ethyl isocyanzacetate

Ethyl isocyanoacetate,97%

Ethyl isocyanoacetate,99+%

ethyl forMylaMinoacetate

Ethyl isocyanoacetate, 97% 5GR

Acetic acid, 2-isocyano-, ethyl ester

Ethyl isocyanoacetate(EICA)

Isocyanoacetic acid ethyl ester, Ethyl 2-isocyanoethanoate

BIO-FARMA BF001872

HANSA ISN-0528

ISOCYANOACETIC ACID ETHYL ESTER

ETHYL ISOCYANOACETATE

Ethyl isocyanoacetate 95%

Ethyl isocyanoacetate FP170213

Ethyl Isocyanoacetate, 95+%

EthylIsocyanoacetate&gt

TIANFU-CHEM - Ethyl isocyanoacetate

Isocyanoacetic acid ethyl este

Ethylisocyanatoactate

2999-46-4

CNCH2COOCH2CH3

CNCH2CO2CH2CH3

ISOCYANATE

Building Blocks

Nitrogen Compounds

Isocyanides

Organic Building Blocks

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis

straight chain compounds

pharmacetical

Naphthyridine,Quinoline

Isocyanides

Nitrogen Compounds

Organic Building Blocks