2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride

Product Name: 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
CAS No.: 42036-65-7
Chemical Name: 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
Synonyms: NSC 12467;NSC 620461;Tramadol EP Impurity E;Tramadol Impurity E HCl;Tramadol EP Impurity E HCl;TraMadol Related CoMpound B;TraMadol Hydrochloride IMpurity-E(EP);Tramadol stg-I mannich HCL EP imp-E RC-B;2-(DIMETHYLAMINOMETHYL) CYCLOHEXANONE HCL;2-(Dimethylaminomethyl)-1-cyclohexanoneHCl
CBNumber: CB7214624
Molecular Formula: C9H18ClNO
Formula Weight: 191.7
MOL File: 42036-65-7.mol

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2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Property

Melting point:: 147-151 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
color: White
Water Solubility: soluble
Major Application: pharmaceutical (small molecule)
InChI: InChI=1S/C9H17NO.ClH/c1-10(2)7-8-5-3-4-6-9(8)11;/h8H,3-7H2,1-2H3;1H
InChIKey: CLVHTSWMNNSUSH-UHFFFAOYSA-N
SMILES: C1(CN(C)C)CCCCC1=O.Cl
CAS DataBase Reference: 42036-65-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: WGK 3
HS Code: 29223900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Dam. 1
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S935484
Product name: 2-(DIMETHYLAMINOMETHYL)-1-CYCLOHEXANONE HYDROCHLORIDE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1672621
Product name: 2-(DIMETHYLAMINOMETHYL)-1-CYCLOHEXANONE HYDROCHLORIDE
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1200
Updated: 2025/07/31

Sigma-Aldrich

Product number: S935484
Product name: 2-(DIMETHYLAMINOMETHYL)-1-CYCLOHEXANONE HYDROCHLORIDE
Purity: Aldrich
Packaging: 50mg
Price: $179
Updated: 2024/03/01

TRC

Product number: B585445
Product name: 2-(Bismethyl)aminomethylcyclohexanoneHydrochloride
Packaging: 2.5g
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 5793AB
Product name: 2-((Dimethylamino)methyl)cyclohexanonehydrochloride
Packaging: 10g
Price: $169
Updated: 2021/12/16

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2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

An impurity found in Tramadol (T712500).

Synthesis

0.982 g (1.03 mL, 10.0 mmol) cyclohexanone, 0.360 g (12.0 mmol) paraformaldehyde, 0.816 g (10.0 mmol) dimethylammonium chloride and 4 mL ethanol are filled in a 25 mL round bottom flask with reflux condenser and magnetic stir bar. 2 drops of conc. hydrochloric acid is added, and the mixture is heated under stirring for 4 hours under reflux. The hot solution is filtered in a round bottom flask, and the solvent is evaporated by the rotary evaporator. The residue is dissolved in 2 mL ethanol under heating. At room temperature, 20 mL acetone is added to the solution. For complete crystallization, the solution is stored overnight in the freezer compartment. The crystallized crude product 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride is sucked off over a Buechner funnel and dried in the desiccator over silica gel.

References

[1] Synlett, 2000, # 3, p. 341 - 342
[2] European Journal of Medicinal Chemistry, 1993, vol. 28, # 4, p. 313 - 322
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 76, # 1-4, p. 115 - 118
[4] Patent: US2017/176476, 2017, A1. Location in patent: Paragraph 0009; 0078

2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Suppliers

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View Lastest Price from 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride 42036-65-7
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

42036-65-7, 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochlorideRelated Search:

4-Dimethylaminobenzaldehyde 4-Dimethylaminopyridine D-Glucosamine hydrochloride Dimethylamine hydrochloride 4-Dimethylaminobenzoic acid Topotecan hydrochloride METHYLCYCLOHEXANONE Cyclohexanone Aminoacetonitrile hydrochloride 2-Dimethylaminoethanol 2-[(DIETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE 2-[(N,N-DIBENZYLAMINO)METHYL]CYCLOHEXANONE, HYDROCHLORIDE 2-(PIPERIDYLMETHYL)-1-CYCLOHEXANONE HYDROCHLORIDE 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride TOSLAB 869097 SPIRO[5,5-DIMETHYL-1,3-CYCLOHEXANEDIONE-2,5'-(9'-CHLORO-3'-PHENYL-2',3',4',4A',5',6'-HEXAHYDRO-1'H-PYRAZINO[1',2'-A']QUINOLINE)] SPIRO[5,5-DIMETHYL-1,3-CYCLOHEXANEDIONE-2,5'-(3'-(3'-CHLOROPHENYL)-2',3',4',4A',5',6'-HEXAHYDRO-1'H-PYRAZINO[1',2'-A]QUINOLINE)] RARECHEM AQ NN 0359

2-(DIMETHYLAMINOMETHYL)-1-CYCLOHEXANONE HYDROCHLORIDE

2-(DIMETHYLAMINOMETHYL)-CYCLOHEXAN-1-ONE HCL

2-(DIMETHYLAMINOMETHYL) CYCLOHEXANONE HCL

2-[(DIMETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE

2-(N,N-DIMETHYLAMINOMETHYL)CYCLOHEXANONE HCL

2-(Dimethylaminomethyl)-1-cyclohexanone, hydrochloride salt

2-(Dimethylamino)methyl cyclhexanone hydrochloride

2-(Dimethylaminomethyl)-1-cyclohexanoneHCl

Tramadol EP Impurity E

Tramadol Impurity 5（Tramadol EP Impurity E）

2-dimethylaminomethyl cyclohexanon hydrochloride

Tramadol Impurity E HCl

2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride 98%

2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride,98%

2-Dimethyl Amino Methyl Cyclohexanone.HCL (Menich Base)

Tramadol Related Compound B (25 mg) (2-(dimethylaminomethyl)-1-cyclohexanone hydrochloride)

2-(DiMethylaMinoMethyl)-1-cyclohexanone hydrochlor

2-(DiMethylaMinoMethyl)-1-cyclohexanone hydrochloride, 98% 1GR

2-(BisMethyl)aMinoMethylcyclohexanone Hydrochloride

DiMethyl((2-oxocyclohexyl)Methyl)aMMoniuM Chloride

NSC 12467

NSC 620461

Cyclohexanone, 2-[(diMethylaMino)Methyl]-, hydrochloride

TraMadol Hydrochloride IMpurity-E(EP)

TraMadol Related CoMpound B

Tramadol EP Impurity E HCl

2 - DIMETHYL - METHYL - 1 CYCLOHEXANONE HYDROCHLORIDE

Tramadol stg-I mannich HCL EP imp-E RC-B

Tramadol EP Impurity E/ Tramadol Related Compound B

Tramadol Related Compound B (2-(dimethylaminomethyl)-1-cyclohexanone hydrochloride) (1672621)

Tramadol Related Compound B as Hydrochloride

Tramadol USP Related Compound B as Hydrochloride

Tramadol Hydrochloride EP Impurity E as Hydrochloride

Tramadol Hydrochloride Impurity E as Hydrochloride

Tramadol Related Compound B (25 mg) (2-[(Dimethylamino)methyl]cyclohexanone hydrochloride)

2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride/DMCH

Tramadol EP Impurity E HCl (Tramadol USP Related Compound B)

(2RS)-2-[(Dimethylamino)methyl]cyclohexanone Hydrochloride

2-((Dimethylamino)methyl)cyclohexan-1-one hydrochloride (Tramadol Impurity)

42036-65-7

C9H17NOClH

C9H17NOHCl

Aminomethyl's

Ring Systems