2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
- Product Name
- 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
- CAS No.
- 42036-65-7
- Chemical Name
- 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
- Synonyms
- NSC 12467;NSC 620461;Tramadol EP Impurity E;Tramadol Impurity E HCl;Tramadol EP Impurity E HCl;TraMadol Related CoMpound B;TraMadol Hydrochloride IMpurity-E(EP);Tramadol stg-I mannich HCL EP imp-E RC-B;2-(DIMETHYLAMINOMETHYL) CYCLOHEXANONE HCL;2-(Dimethylaminomethyl)-1-cyclohexanoneHCl
- CBNumber
- CB7214624
- Molecular Formula
- C9H18ClNO
- Formula Weight
- 191.7
- MOL File
- 42036-65-7.mol
2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Property
- Melting point:
- 147-151 °C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- color
- White
- Water Solubility
- soluble
- InChI
- InChI=1S/C9H17NO.ClH/c1-10(2)7-8-5-3-4-6-9(8)11;/h8H,3-7H2,1-2H3;1H
- InChIKey
- CLVHTSWMNNSUSH-UHFFFAOYSA-N
- SMILES
- C1(CN(C)C)CCCCC1=O.Cl
- CAS DataBase Reference
- 42036-65-7(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- HS Code
- 29223900
N-Bromosuccinimide Price
- Product number
- S935484
- Product name
- 2-(DIMETHYLAMINOMETHYL)-1-CYCLOHEXANONE HYDROCHLORIDE
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 1672621
- Product name
- 2-(DIMETHYLAMINOMETHYL)-1-CYCLOHEXANONE HYDROCHLORIDE
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1210
- Updated
- 2024/03/01
- Product number
- B585445
- Product name
- 2-(Bismethyl)aminomethylcyclohexanoneHydrochloride
- Packaging
- 2.5g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FD149699
- Product name
- 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FD149699
- Product name
- 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
- Packaging
- 2g
- Price
- $300
- Updated
- 2021/12/16
2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
An impurity found in Tramadol (T712500).
Synthesis
0.982 g (1.03 mL, 10.0 mmol) cyclohexanone, 0.360 g (12.0 mmol) paraformaldehyde, 0.816 g (10.0 mmol) dimethylammonium chloride and 4 mL ethanol are filled in a 25 mL round bottom flask with reflux condenser and magnetic stir bar. 2 drops of conc. hydrochloric acid is added, and the mixture is heated under stirring for 4 hours under reflux. The hot solution is filtered in a round bottom flask, and the solvent is evaporated by the rotary evaporator. The residue is dissolved in 2 mL ethanol under heating. At room temperature, 20 mL acetone is added to the solution. For complete crystallization, the solution is stored overnight in the freezer compartment. The crystallized crude product 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride is sucked off over a Buechner funnel and dried in the desiccator over silica gel.
2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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