ChemicalBook > CAS DataBase List > 3'-Chloropropiophenone

3'-Chloropropiophenone

Product Name: 3'-Chloropropiophenone
CAS No.: 34841-35-5
Chemical Name: 3'-Chloropropiophenone
Synonyms: MCPP;M-CHLOROPROPIOPHENONE;1-(3-chlorophenyl)propan-1-one;3&priMe;3-chlorophenone;3'-chloroacetone;M-ChloroProiophenone;3'-Chloropropiopheno;Bupropion Impurity 22;Bupropion Impurity 48
CBNumber: CB7234165
Molecular Formula: C9H9ClO
Formula Weight: 168.62
MOL File: 34841-35-5.mol

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3'-Chloropropiophenone Property

Melting point:: 45-47 °C(lit.)
Boiling point:: 124 °C14 mm Hg(lit.)
Density: 1.1115 (rough estimate)
refractive index: 1.5350 (estimate)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in methanol.
form: Crystalline Solid
color: White to light yellow
InChI: InChI=1S/C9H9ClO/c1-2-9(11)7-4-3-5-8(10)6-7/h3-6H,2H2,1H3
InChIKey: PQWGFUFROKIJBO-UHFFFAOYSA-N
SMILES: C(C1=CC=CC(Cl)=C1)(=O)CC
LogP: 3.041
CAS DataBase Reference: 34841-35-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-24/25
WGK Germany: 3
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 248193
Product name: 3′-Chloropropiophenone
Purity: 98%
Packaging: 50g
Price: $160
Updated: 2025/07/31

TCI Chemical

Product number: C2033
Product name: 3'-Chloropropiophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: C2033
Product name: 3'-Chloropropiophenone
Purity: >98.0%(GC)
Packaging: 250g
Price: $172
Updated: 2025/07/31

TRC

Product number: C379845
Product name: 3''-Chloropropiophenone
Packaging: 1g
Price: $95
Updated: 2021/12/16

TRC

Product number: C379845
Product name: 3''-Chloropropiophenone
Packaging: 10g
Price: $135
Updated: 2021/12/16

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3'-Chloropropiophenone Chemical Properties,Usage,Production

Description

Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE SOLID

Uses

3'-Chloropropiophenone has been used in the preparation of 1-(3-chlorophenyl)-1-phenyl-1-propanol.

Uses

3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.

Application

3′-Chloropropiophenone can be used as a reactant to synthesize:
(S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
(S)-Dapoxetine, a selective serotonin reuptake inhibitor.

Preparation

4.86 g (0.2 mol) of magnesium turnings, 30 ml of dry diethyl ether and a grain of iodine are placed in a one liter three-necked round-bottomed flask equipped with a condenser, a calcium chloride drying tube, a pressure equalizing funnel and a magnetic stirrer; the flask is purged with nitrogen, and 21.8 g (0.2 mol) of ethyl bromide in 30 ml of dry diethyl ether are then added. The mixture is then heated under reflux for one hour and left to cool. At ambient temperature, 16.51 g (0.12 mol) of 3-chlorobenzonitrile in 70 ml of dry diethyl ether are then added. A copious precipitate forms. The mixture is stirred overnight at ambient temperture and then cooled in an ice bath and hydrolysed by slowly adding 50 ml of water and then about 100 ml of 6N hydrochloric acid until the pH is acid. The mixture is stirred for one and a half hours and then extracted with ethyl acetate. The organic extract is then washed twice with water, dried and concentrated on a rotary evaporator. This gives 26 g of an orange oil, which is concentrated in vacuo to give about 18.2 g of ochre crystals of 3'-chloropropiophenone melting at about 40° C.
Literature source US04690931

Synthesis

63503-60-6

107-12-0

34841-35-5

In a high-pressure reactor equipped with a 10 mL PTFE liner, NiBr2-diglycol dimethyl ether (5 mol%), 1,10-phenanthroline (10 mol%) and a magnetic stirrer were added sequentially. Subsequently, 3-chlorophenylboronic acid (1.0 mmol), NaHCO3 (2.0 equiv), H2O (2.0 mmol) and propionitrile (1.0 mL) were added to the reactor. After sealing the autoclave, it was cooled to low temperature in liquid nitrogen, followed by evacuation and addition of HCFC-244bb (2.0 mL, 2.6 g) by self-priming. The autoclave was transferred to a 100 °C oil bath and the reaction was stirred for 5 hours. Upon completion of the reaction, the autoclave was cooled to room temperature and the excess HCFC-244bb was slowly released. water (30 mL) was added to the reaction mixture and extracted with dichloromethane (3 x 15 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous Na2SO4 and concentrated under reduced pressure to remove the organic solvent. The crude product was purified by column chromatography.

References

[1] Synlett, 2018, vol. 29, # 5, p. 593 - 596

3'-Chloropropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3'-Chloropropiophenone Suppliers

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View Lastest Price from 3'-Chloropropiophenone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3′-Chloropropiophenone 34841-35-5
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 1 ton
Release date: 2025-06-10

Hebei Yiduo Import and Export Co., Ltd.

Product: 3'-Chloropropiophenone 34841-35-5
Price: US $100.00-80.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000000
Release date: 2025-05-21

RongNa Biotechnology Co.,Ltd

Product: 3-CHLORO PROPIOPHENONE 34841-35-5
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-05-15

34841-35-5, 3'-ChloropropiophenoneRelated Search:

3-Chlorophenol Acetylacetone Calcium pyruvate Hexachloroacetone 1,3-Dichlorobenzene 4'-Chloropropiophenone 1,1,3-Trichloroacetone 1-Chloro-3-nitrobenzene Chlorphenamine maleate Citric acid monohydrate 3'-Hydroxypropiophenone Pyruvic acid 3-Chloroanisole 3-Chloropropiophenone 3-Chlorobenzonitrile BUPROPION MORPHOLINOL 1-(3-Chlorophenyl)-1,2-propanedione Bupropion Hydrochloride Related Compound A (15 mg) (2-(tert-butylamino)-4'-chloropropiophenone hydrochloride)

3-CHLOROPHENYL ETHYL KETONE

(3-CHLOROPHENYL)PROPAN-1-ONE

M-CHLOROPROPIOPHENONE

MCPP

1-(3-CHLOROPHENYL)-1-PROPANONE

3-CHLORO-1-PHENYL-PROPANONE

3-CHLOROPROPIOPHENONE M-CHLORO PROPIOPHENONE

3-Chloro-Propiophenone(M-ChloroProiophenone)

M-ChloroProiophenone

1-(3-chlorophenyl)propan-1-one

3'-Chloropropiophenone

3'-Chloropropiopheno

Between chloropropiophenone

1-Propanone, 1-(3-chlorophenyl)-

Bupropion Des-t-ButylaMino IMpurity

3&priMe

Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone

Bupropion Impurity 14 (3'-Chloropropiophenone)

Bupropion Impurity 22

3'-chloroacetone

：3’-Chloropropiophenone，1-(3-chlorophenyl)propan-1-one

3 '- chlorobenzene acetone

3'-Chloropropiophenone Synonyms 1-(3-Chlorophenyl)-1-propanone

3'-Chloropropiophenone, 97+%

Bupropion Hydrochloride Impurity Ⅰ（3-chloropropiophenone）

Chloropropiophenone Chloropropiophenone

MCPP 3'-Chloropropiophenone

3'-Chloropropiophenone USP/EP/BP

3'-Chloropropiophenone/META CHLOROPROPIOPHENONE

3’-ChloropropiophenoneQ: What is 3’-Chloropropiophenone Q: What is the CAS Number of 3’-Chloropropiophenone Q: What is the storage condition of 3’-Chloropropiophenone Q: What are the applications of 3’-Chloropropiophenone

1-(3-Chlorphenyl)propan-1-on

Bupropion Hydrochloride Impurity Ⅰ (3-chloropropiophenone)

DES-T-BUTYLAMINO IMPURITY

Meta Chloropropiophenone

3-chlorophenone

Bupropion Intermediate

Meta - Chloropropiophenone ( 3 - Chloropropiophenone )

Chloropropiophenone (10 mg) (1-(3-Chlorophenyl)propan-1-one) (COLD SHIPMENT REQUIRED)

3'-Chloropropiophenone, ≥ 98.0%

Bupropion Des-tert-butylamine Impurity

Bupropion Impurity 48

1-(3-Chlorophenyl)propan-1-one (Bupropion Impurity)

3′-Chloropropiophenone, CAS 34841-35-5

3Chemicalbook-CHLORO-1-PHENYL-PROPANONE

Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone

1-(3-Chlorophenyl)propan-1-one - [C93020]

34841-35-5

Organic Building Blocks

Ketones

Building Blocks

Carbonyl Compounds

KETONE

Carbonyl Compounds

Ketones

Aromatic Propiophenones (substituted)

Aromatic Ketones (substituted)