ChemicalBook > CAS DataBase List > 3'-Chloropropiophenone

3'-Chloropropiophenone

Product Name
3'-Chloropropiophenone
CAS No.
34841-35-5
Chemical Name
3'-Chloropropiophenone
Synonyms
MCPP;M-CHLOROPROPIOPHENONE;1-(3-chlorophenyl)propan-1-one;3&priMe;3-chlorophenone;3'-chloroacetone;M-ChloroProiophenone;3'-Chloropropiopheno;Bupropion Impurity 22;Bupropion Impurity 48
CBNumber
CB7234165
Molecular Formula
C9H9ClO
Formula Weight
168.62
MOL File
34841-35-5.mol
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3'-Chloropropiophenone Property

Melting point:
45-47 °C(lit.)
Boiling point:
124 °C14 mm Hg(lit.)
Density 
1.1115 (rough estimate)
refractive index 
1.5350 (estimate)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in methanol.
form 
Crystalline Solid
color 
White to light yellow
InChI
InChI=1S/C9H9ClO/c1-2-9(11)7-4-3-5-8(10)6-7/h3-6H,2H2,1H3
InChIKey
PQWGFUFROKIJBO-UHFFFAOYSA-N
SMILES
C(C1=CC=CC(Cl)=C1)(=O)CC
LogP
3.041
CAS DataBase Reference
34841-35-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-24/25
WGK Germany 
3
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
248193
Product name
3′-Chloropropiophenone
Purity
98%
Packaging
50g
Price
$155
Updated
2024/03/01
TCI Chemical
Product number
C2033
Product name
3'-Chloropropiophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
C2033
Product name
3'-Chloropropiophenone
Purity
>98.0%(GC)
Packaging
250g
Price
$172
Updated
2024/03/01
Alfa Aesar
Product number
A12542
Product name
3'-Chloropropiophenone, 98%
Packaging
25g
Price
$30.65
Updated
2024/03/01
Alfa Aesar
Product number
A12542
Product name
3'-Chloropropiophenone, 98%
Packaging
100g
Price
$76.65
Updated
2024/03/01
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3'-Chloropropiophenone Chemical Properties,Usage,Production

Description

Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE SOLID

Uses

3'-Chloropropiophenone has been used in the preparation of 1-(3-chlorophenyl)-1-phenyl-1-propanol.

Uses

3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.

Application

3′-Chloropropiophenone can be used as a reactant to synthesize:
(S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
(S)-Dapoxetine, a selective serotonin reuptake inhibitor.

Preparation

4.86 g (0.2 mol) of magnesium turnings, 30 ml of dry diethyl ether and a grain of iodine are placed in a one liter three-necked round-bottomed flask equipped with a condenser, a calcium chloride drying tube, a pressure equalizing funnel and a magnetic stirrer; the flask is purged with nitrogen, and 21.8 g (0.2 mol) of ethyl bromide in 30 ml of dry diethyl ether are then added. The mixture is then heated under reflux for one hour and left to cool. At ambient temperature, 16.51 g (0.12 mol) of 3-chlorobenzonitrile in 70 ml of dry diethyl ether are then added. A copious precipitate forms. The mixture is stirred overnight at ambient temperture and then cooled in an ice bath and hydrolysed by slowly adding 50 ml of water and then about 100 ml of 6N hydrochloric acid until the pH is acid. The mixture is stirred for one and a half hours and then extracted with ethyl acetate. The organic extract is then washed twice with water, dried and concentrated on a rotary evaporator. This gives 26 g of an orange oil, which is concentrated in vacuo to give about 18.2 g of ochre crystals of 3'-chloropropiophenone melting at about 40° C.
Literature source US04690931

3'-Chloropropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3'-Chloropropiophenone Suppliers

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View Lastest Price from 3'-Chloropropiophenone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
3'-Chloropropiophenone 34841-35-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-04-30
Hebei Weibang Biotechnology Co., Ltd
Product
3'-Chloropropiophenone 34841-35-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
Hebei Weibang Biotechnology Co., Ltd
Product
3'-Chloropropiophenone 34841-35-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01

34841-35-5, 3'-ChloropropiophenoneRelated Search:

3-Chlorophenol Acetylacetone Calcium pyruvate Hexachloroacetone 1,3-Dichlorobenzene 4'-Chloropropiophenone 1,1,3-Trichloroacetone 1-Chloro-3-nitrobenzene Chlorphenamine maleate Citric acid monohydrate 3'-Hydroxypropiophenone Pyruvic acid 3-Chloroanisole 3-Chloropropiophenone 3-Chlorobenzonitrile BUPROPION MORPHOLINOL 1-(3-Chlorophenyl)-1,2-propanedione Bupropion Hydrochloride Related Compound A (15 mg) (2-(tert-butylamino)-4'-chloropropiophenone hydrochloride)

  • 3-CHLOROPHENYL ETHYL KETONE
  • (3-CHLOROPHENYL)PROPAN-1-ONE
  • M-CHLOROPROPIOPHENONE
  • MCPP
  • 1-(3-CHLOROPHENYL)-1-PROPANONE
  • 3-CHLORO-1-PHENYL-PROPANONE
  • 3-CHLOROPROPIOPHENONE M-CHLORO PROPIOPHENONE
  • 3-Chloro-Propiophenone(M-ChloroProiophenone)
  • M-ChloroProiophenone
  • 1-(3-chlorophenyl)propan-1-one
  • 3'-Chloropropiophenone
  • 3'-Chloropropiopheno
  • Between chloropropiophenone
  • 1-Propanone, 1-(3-chlorophenyl)-
  • Bupropion Des-t-ButylaMino IMpurity
  • 3&priMe
  • Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
  • Bupropion Impurity 14 (3'-Chloropropiophenone)
  • Bupropion Impurity 22
  • 3'-chloroacetone
  • ：3’-Chloropropiophenone，1-(3-chlorophenyl)propan-1-one
  • 3 '- chlorobenzene acetone
  • 3'-Chloropropiophenone Synonyms 1-(3-Chlorophenyl)-1-propanone
  • 3'-Chloropropiophenone, 97+%
  • Bupropion Hydrochloride Impurity Ⅰ（3-chloropropiophenone）
  • Chloropropiophenone Chloropropiophenone
  • MCPP 3'-Chloropropiophenone
  • 3'-Chloropropiophenone USP/EP/BP
  • 3'-Chloropropiophenone/META CHLOROPROPIOPHENONE
  • 3’-ChloropropiophenoneQ: What is 3’-Chloropropiophenone Q: What is the CAS Number of 3’-Chloropropiophenone Q: What is the storage condition of 3’-Chloropropiophenone Q: What are the applications of 3’-Chloropropiophenone
  • 1-(3-Chlorphenyl)propan-1-on
  • Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
  • Bupropion Hydrochloride Impurity Ⅰ (3-chloropropiophenone)
  • DES-T-BUTYLAMINO IMPURITY
  • Meta Chloropropiophenone
  • 3-chlorophenone
  • Bupropion Intermediate
  • Meta - Chloropropiophenone ( 3 - Chloropropiophenone )
  • Chloropropiophenone (10 mg) (1-(3-Chlorophenyl)propan-1-one) (COLD SHIPMENT REQUIRED)
  • 1-(3-Chlorophenyl)propan-1-one (Bupropion Impurity)
  • 3'-Chloropropiophenone, ≥ 98.0%
  • 3'-Chloropropiophenone
  • Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
  • Bupropion Des-tert-butylamine Impurity
  • Bupropion Impurity 48
  • 34841-35-5
  • Organic Building Blocks
  • Ketones
  • Building Blocks
  • Carbonyl Compounds
  • C9
  • KETONE
  • C9
  • Carbonyl Compounds
  • Ketones
  • Aromatic Propiophenones (substituted)
  • Aromatic Ketones (substituted)
  • Aromatic Halides (substituted)