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C5, HUMAN

Product Name
C5, HUMAN
CAS No.
80295-53-0
Chemical Name
C5, HUMAN
Synonyms
C5, HUMAN;C5 Protein;COMPLEMENT C5;COMPLEMENT C5, HUMAN;COMPLEMENT C5 FROM HUMAN SERUM
CBNumber
CB7239438
Formula Weight
0
MOL File
Mol file
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C5, HUMAN Property

storage temp. 
-70°C
form 
Liquid
biological source
human serum
Specific Activity
>100,000C5H50 units/mg protein
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Safety

Hazard Codes 
B
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C3160
Product name
Complement C5 from human serum
Purity
≥90% (SDS-PAGE), >100,000?C5H50 units/mg protein
Packaging
0.1mg
Price
$354
Updated
2024/03/01
Sigma-Aldrich
Product number
204888
Product name
Complement C5, Human
Purity
Complement C5, Human, CAS 80295-53-0. is a native glycoprotein composed of two non-identical subunits of M.W. 120 kDa (α) and 75 kDa (β) linked by disulfide bonds.
Packaging
250μg
Price
$520
Updated
2024/03/01
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C5, HUMAN Chemical Properties,Usage,Production

Uses

Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.

General Description

Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120 kDa (α) and 75 kDa (β) linked by disulfide bonds. Present in normal human serum at 70 μg/ml. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).

Biochem/physiol Actions

Complement component C5 is processed by convertase enzymes in a cascade modulated in a unique way. The multi-subunit catalytic complex initially shows little activity against C5, but instead cleaves C3. A C3 cleavage product C3b covalently attaches to the complex and shifts its specificity to C5 by a factor of 1000.

C5, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

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C5, HUMAN Suppliers

ecochem international chemical broker
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export@ecochem.dk
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kemikalieimport
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80295-53-0, C5, HUMANRelated Search:


  • C5, HUMAN
  • COMPLEMENT C5, HUMAN
  • COMPLEMENT C5
  • COMPLEMENT C5 FROM HUMAN SERUM
  • C5 Protein
  • 80295-53-0
  • Complement Proteins
  • Complement Factor Proteins
  • Enzymes, Inhibitors, and Substrates
  • BioChemical
  • Biochemicals and Reagents
  • Cell Signaling Enzymes
  • Application Index
  • Complement Factor ProteinsProteins and Derivatives
  • Plasma Protein Composition
  • Complement Proteins
  • ComplementCell Signaling Enzymes
  • Plasma&Blood Proteins
  • Plasma, Blood, and Related Proteins and Reagents