MK-2206 2HCl
- Product Name
- MK-2206 2HCl
- CAS No.
- 1032350-13-2
- Chemical Name
- MK-2206 2HCl
- Synonyms
- MK-2206;CS-260;MK-2206 2HCl;MK-2206 HCl salt;MK-2206 2HCL;MK2206;Benodanil Impurity 9;MK-2206 2HCl USP/EP/BP;MK 2206 (hydrochloride);MK-2206 Dihydrochloride;MK 2206 2HCL;MK2206 2HCL
- CBNumber
- CB72489901
- Molecular Formula
- C25H22ClN5O
- Formula Weight
- 443.94
- MOL File
- 1032350-13-2.mol
MK-2206 2HCl Property
- Melting point:
- >255°C (dec.)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml with warming)
- form
- Yellow powder.
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11593
- Product name
- MK-2206 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $43
- Updated
- 2024/03/01
- Product number
- 11593
- Product name
- MK-2206 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 11593
- Product name
- MK-2206 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 11593
- Product name
- MK-2206 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $137
- Updated
- 2024/03/01
- Product number
- M4095-40
- Product name
- MK-2206
- Packaging
- 500ug
- Price
- $316
- Updated
- 2021/12/16
MK-2206 2HCl Chemical Properties,Usage,Production
Description
MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the?in vitro?and?in vivo?antitumor efficacy of several standard chemotherapeutic agents.1?It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2?MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3
Uses
A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.
Uses
AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.
target
Akt1
storage
-20°C
References
1) Hirai?et al.?(2010),?MK-2206, an Allosteric Akt inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular targeted Drugs In vitro and In vivo; Mol. Cancer Ther.?9?1956 2) Lai?et al.?(2012),?A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle; Biochem. J.?447?137 3) Jiao?et al.?(2013),?MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death; Mol. Cell Biochem.?382?217
MK-2206 2HCl Preparation Products And Raw materials
Raw materials
Preparation Products
MK-2206 2HCl Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from MK-2206 2HCl manufacturers
- Product
- MK-2206 2HCl 1032350-13-2
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000t/year
- Release date
- 2023-09-07
- Product
- MK-2206 2HCl 1032350-13-2
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23