ChemicalBook > CAS DataBase List > MK-2206 2HCl

MK-2206 2HCl

Product Name
MK-2206 2HCl
CAS No.
1032350-13-2
Chemical Name
MK-2206 2HCl
Synonyms
MK-2206;CS-260;MK-2206 2HCl;MK-2206 HCl salt;MK-2206 2HCL;MK2206;Benodanil Impurity 9;MK-2206 2HCl USP/EP/BP;MK 2206 (hydrochloride);MK-2206 Dihydrochloride;MK 2206 2HCL;MK2206 2HCL
CBNumber
CB72489901
Molecular Formula
C25H22ClN5O
Formula Weight
443.94
MOL File
1032350-13-2.mol
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MK-2206 2HCl Property

Melting point:
>255°C (dec.)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 10 mg/ml with warming)
form 
Yellow powder.
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11593
Product name
MK-2206 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$43
Updated
2024/03/01
Cayman Chemical
Product number
11593
Product name
MK-2206 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
11593
Product name
MK-2206 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
11593
Product name
MK-2206 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$137
Updated
2024/03/01
Usbiological
Product number
M4095-40
Product name
MK-2206
Packaging
500ug
Price
$316
Updated
2021/12/16
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MK-2206 2HCl Chemical Properties,Usage,Production

Description

MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the?in vitro?and?in vivo?antitumor efficacy of several standard chemotherapeutic agents.1?It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2?MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3

Uses

A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.

Uses

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.

Uses

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vi vo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents.

target

Akt1

storage

-20°C

References

1) Hirai?et al.?(2010),?MK-2206, an Allosteric Akt inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular targeted Drugs In vitro and In vivo; Mol. Cancer Ther.?9?1956 2) Lai?et al.?(2012),?A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle; Biochem. J.?447?137 3) Jiao?et al.?(2013),?MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death; Mol. Cell Biochem.?382?217

MK-2206 2HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-2206 2HCl Suppliers

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View Lastest Price from MK-2206 2HCl manufacturers

Anhui Ruihan Technology Co., Ltd
Product
MK-2206 2HCl 1032350-13-2
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000t/year
Release date
2023-09-07
Career Henan Chemical Co
Product
MK-2206 2HCl 1032350-13-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1032350-13-2, MK-2206 2HClRelated Search:

MK-4101 mk-1064 MK 0557 MK-5172 Mk-2461 . (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Omarigliptin (MK-3102) Selumetinib Pictilisib Trametinib LY 294002 HYDROCHLORIDE Rapamycin MK-8353 MK-8998 MK-1775 SCH900776 MK-3903 MK-0941

  • MK-2206
  • MK-2206 Dihydrochloride
  • 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
  • MK 2206 2HCL;MK2206 2HCL
  • CS-260
  • MK2206; MK-2206; MK 2206; MK2206 DIHYDROCHLORIDE; MK2206 HCL.
  • 8-[4-(1-AMinocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Hydrochloride
  • 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
  • 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride MK-2206
  • MK-2206 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
  • MK 2206 (hydrochloride)
  • MK-2206 2HCl
  • MK-2206 dihydrochloride, >=98%
  • MK-2206 2HCL;MK2206
  • 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochlorideMK-2206 Dihydrochloride
  • MK-2206 HCl salt
  • 1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2)
  • (8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one) dihydrochloride
  • MK 2206 dihydrochloride, 98%, an allosteric Akt inhibitor
  • 8-[4-(1-AMINOCYCLOBUTYL)PHENYL]-9-PHENYL-1,2,4-TRIAZOLO[3,4-F][1,6]NAPHTHYRIDIN-3(2H)-ONE 2HCL
  • MK 2206 2HCL;MK2206 2HCL;MK-2206 DIHYDROCHLORIDE;MK2206 DIHYDROCHLORIDE
  • MK-2206 2HCl USP/EP/BP
  • MK-2206 2HCl/MK-2206 dihydrochloride
  • MK-2206 dihydrochloride MK2206
  • Benodanil Impurity 9
  • MK-2206 DIHYDROCHLORIDE SALT (2XHCL SALT)
  • 1032350-13-2
  • C25H21N5O2HCl
  • C25H23Cl2N5O
  • C25H21N5O2ClH
  • Inhibitor
  • PI3K/Akt/mTOR
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals