Abacavir 5’-Phosphate

Product Name: Abacavir 5’-Phosphate
CAS No.: 136470-77-4
Chemical Name: Abacavir 5’-Phosphate
Synonyms: Abacavir Impurity 13;Abacavir 5'-Phosphate;Abacavir 5’-Phosphate;(1S-cis)-Abacavir Monophosphate;[(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methyl dihydrogen phosphate;((1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methyl dihydrogen phosphate;2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, 1-(dihydrogen phosphate), (1S,4R)-;(1S,4R)- 4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-Methanol Dihydrogen Phosphate (Ester)
CBNumber: CB72502992
Molecular Formula: C14H19N6O4P
Formula Weight: 366.31
MOL File: 136470-77-4.mol

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Abacavir 5’-Phosphate Property

Melting point:: 189-194°C (dec.)
Boiling point:: 749.3±70.0 °C(Predicted)
Density: 1.93±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Methanol, Water
pka: 1.91±0.10(Predicted)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A105020
Product name: Abacavir5’-Phosphate
Packaging: 1mg
Price: $90
Updated: 2021/12/16

TRC

Product number: A105020
Product name: Abacavir5’-Phosphate
Packaging: 10mg
Price: $625
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NA16495
Product name: Abacavir 5'-phosphate
Packaging: 5mg
Price: $1051.1
Updated: 2021/12/16

AK Scientific

Product number: 3389CC
Product name: Abacavir5'-phosphate
Packaging: 5mg
Price: $1468
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NA16495
Product name: Abacavir 5'-phosphate
Packaging: 10mg
Price: $1911
Updated: 2021/12/16

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Abacavir 5’-Phosphate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Definition

ChEBI: Abacavir monophosphate is the organic phosphate that is the 5'-monophosphate of abacavir. It has a role as a metabolite. It is a member of 2,6-diaminopurines and an organic phosphate. It is functionally related to an abacavir.

Abacavir 5’-Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Abacavir 5’-Phosphate Suppliers

Canada 1 China 16 India 5 United Kingdom 1 United States 2 Global 25

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136470-77-4, Abacavir 5’-PhosphateRelated Search:

Abacavir 2,6-Diaminopurine (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol Abacavir 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- trans-Abacavir Hydrochloride 2-Amino-6-cyclopropylamino-9H-purine (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Abacavir Abacavir 5'-Glucuronide Abacavir Abacavir-d4 Abacavir Related CoMpound D Abacavir Carboxylate (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride Abacavir sulfate 6-aminocarbovir Abacavir Impurity 1

[(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methyl dihydrogen phosphate

Abacavir 5’-Phosphate

(1S,4R)- 4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-Methanol Dihydrogen Phosphate (Ester)

(1S-cis)-Abacavir Monophosphate

((1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methyl dihydrogen phosphate

2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, 1-(dihydrogen phosphate), (1S,4R)-

Abacavir Impurity 13

Abacavir 5'-Phosphate

136470-77-4

C14H19N6O4P

Bases & Related Reagents

Intermediates & Fine Chemicals

Metabolites & Impurities

Nucleotides

Pharmaceuticals

Phosphorylating and Phosphitylating Agents