ChemicalBook > CAS DataBase List > 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine

5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine

Product Name
5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
CAS No.
870483-87-7
Chemical Name
5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
Synonyms
CS-621;GW2580;SC-203877;GW2580, >=98%;GW2580,GW-2580;SC-203877/GW2580;GW2580 (SC203877);GW2580 (DMSO solution);GW 2580; GW-2580; GW 2580.;cFMS receptor TK inhibitor
CBNumber
CB72510269
Molecular Formula
C20H22N4O3
Formula Weight
366.41
MOL File
870483-87-7.mol
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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Property

Boiling point:
617.5±65.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble10mg/mL, clear (warmed)
form 
powder
pka
7.11±0.10(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1047
Product name
GW 2580
Purity
≥98% (HPLC)
Packaging
5mg
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
344036-M
Product name
cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
Packaging
1mg
Price
$153
Updated
2024/03/01
TCI Chemical
Product number
G0504
Product name
GW 2580
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$244
Updated
2024/03/01
TCI Chemical
Product number
G0504
Product name
GW 2580
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$725
Updated
2024/03/01
Cayman Chemical
Product number
15411
Product name
GW 2580
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Chemical Properties,Usage,Production

Description

GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM)1. GW-2580 completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. GW-2580 abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.

Uses

GW2580 has been used to study its effect on paracrine signaling from stretched cardiomyocyte on cardiac fibroblast phenotype.

Biochem/physiol Actions

GW2580 is a cell-permeable, potent and selective ATP-competitive inhibitor of cFMS kinase, receptor for macrophage-colony stimulating factor, M-CSF or CSF-1, and a key regulator of macrophage and osteoclast activation and differentiation. FMS is a type III receptor tyrosine kinase that binds to the macrophage or monocyte colony-stimulating factor (M-CSF or CSF-1). Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states including the growth of metastasis of some types of cancer, in promoting osteoclast proliferation in bone osteolysis, and in several inflammatory disorders. GW2580 selectively inhibits cFMS-mediated cellular functions in vitro at 0.06 μM as well as CSF-1-dependent tumor growth in vivo. GW2580 was inactive against 26 other kinases.

storage

Store at -20°C

References

1) Conway et al. (2005), Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580; Proc. Natl. Acad. Sci. USA, 102 16078 2) Paniagua et al. (2010), c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis; Arthritis Res. Ther., 12 R32

5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Suppliers

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870483-87-7, 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamineRelated Search:

GW284543 GW788388 GW9662 GW441756 GW5074 BUTEIN Cabozantinib Saracatinib Pictilisib Sunitinib Malate Afatinib mycotrienin II SU 4312 LDN 193189 hydrochloride HARMINE HYDROCHLORIDE GW 284543 hydrochloride - UNC 10225170 hydrochloride GW9508 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

  • 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
  • GW2580
  • SC-203877
  • SC-203877/GW2580
  • 2,4-Pyrimidinediamine, 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-
  • 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-Pyrimidinediamine
  • GW 2580; GW-2580; GW 2580.
  • CS-621
  • cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
  • 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
  • GW2580, >=98%
  • cFMS Receptor Tyrosine Kinase Inhibitor
  • cFMS receptor TK inhibitor
  • GW2580,GW-2580
  • 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine USP/EP/BP
  • GW2580 (SC203877)
  • GW2580 (DMSO solution)
  • 870483-87-7
  • Inhibitors