ML 141

Product Name: ML 141
CAS No.: 71203-35-5
Chemical Name: ML 141
Synonyms: ML 141;CS-1743;CID-2950007;ML141;ML 141;ML 141 USP/EP/BP;ML141(CID-2950007);ML141;ML 141;CID-2950007;Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem;5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline;4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
CBNumber: CB72538281
Molecular Formula: C22H21N3O3S
Formula Weight: 407.49
MOL File: 71203-35-5.mol

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ML 141 Property

Melting point:: 216 °C(Solv: ethanol (64-17-5))
Boiling point:: 622.9±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL (warmed, clear solution)
form: Yellow-white solid
pka: 10.39±0.10(Predicted)
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0407
Product name: ML 141
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: 217708
Product name: Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
Packaging: 25mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 18496
Product name: ML 141
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18496
Product name: ML 141
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0407
Product name: ML 141
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $505
Updated: 2024/03/01

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ML 141 Chemical Properties,Usage,Production

Uses

ML 141 has been used:

to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Definition

ChEBI: 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide is a sulfonamide.

Biochem/physiol Actions

ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.

storage

Store at +4°C

ML 141 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML 141 Suppliers

China 86 India 1 United Kingdom 2 United States 16 Global 105

EMMX Biotechnology LLC

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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Santa Cruz Biotechnology, Inc.

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71203-35-5, ML 141Related Search:

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4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide

CID-2950007

4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141

4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide

ML 141

5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline

ML141;ML 141

4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide

4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

CS-1743

ML141(CID-2950007)

ML141;ML 141;CID-2950007

Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem

4-[2-(1-PIPERIDINYL)ETHYL]-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZI<WBR />NE TRIHYDROCHLORIDE

Benzenesulfonamide, 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-

ML 141 USP/EP/BP

71203-35-5

Inhibitors

API