ChemicalBook > CAS DataBase List > 8-BroMo-2-chloro-6-fluoro-quinazoline

8-BroMo-2-chloro-6-fluoro-quinazoline

Product Name: 8-BroMo-2-chloro-6-fluoro-quinazoline
CAS No.: 953039-63-9
Chemical Name: 8-BroMo-2-chloro-6-fluoro-quinazoline
Synonyms: 8-Bromo-2-chloro-6-fluoro-quizoline;8-BroMo-2-chloro-6-fluoro-quinazoline;Quinazoline, 8-bromo-2-chloro-6-fluoro-
CBNumber: CB72594302
Molecular Formula: C8H3BrClFN2
Formula Weight: 261.48
MOL File: 953039-63-9.mol

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8-BroMo-2-chloro-6-fluoro-quinazoline Property

Boiling point:: 308.8±35.0 °C(Predicted)
Density: 1.836
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: Solid
pka: -1.75±0.30(Predicted)
Appearance: White to light brown Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B685613
Product name: 8-Bromo-2-chloro-6-fluoroquinazoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B685613
Product name: 8-Bromo-2-chloro-6-fluoroquinazoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0368432
Product name: 8-BROMO-2-CHLORO-6-FLUOROQUINAZOLINE
Purity: 95.00%
Packaging: 5MG
Price: $499.73
Updated: 2021/12/16

Matrix Scientific

Product number: 091904
Product name: 8-Bromo-2-chloro-6-fluoroquinazoline
Purity: 95+%
Packaging: 250mg
Price: $515
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-F-12
Product name: 8-Bromo-2-chloro-6-fluoroquinazoline
Purity: 98%
Packaging: 250mg
Price: $643
Updated: 2021/12/16

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8-BroMo-2-chloro-6-fluoro-quinazoline Chemical Properties,Usage,Production

Synthesis

953039-62-8

953039-63-9

Step 5. Synthesis of 8-bromo-2-chloro-6-fluoroquinazoline: 0.5 M of 8-bromo-6-fluoroquinazolin-2(1H)-one was suspended in phosphorochloridic acid chloride and heated to 110 °C in an oil bath. During the reaction, the suspension transformed to a brown solution within 20 min. The reaction was completed after 1 h as monitored by LCMS. Subsequently, the excess phosphorus trichloride was removed by distillation under reduced pressure. The residue was carefully poured into ice water and the pH was adjusted with aqueous sodium bicarbonate to 7. The reaction mixture was extracted with ethyl acetate, the organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the target compound 8-bromo-2-chloro-6-fluoroquinazoline in 89% yield. The product was characterized by electrospray mass spectrometry (ES/MS) with m/z of 261/263 (MH+).

References

[1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 332
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0203; 0212
[3] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0510-0511

8-BroMo-2-chloro-6-fluoro-quinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 8-BroMo-2-chloro-6-fluoro-quinazoline manufacturers

Career Henan Chemical Co

Product: 8-Bromo-2-chloro-6-fluoroquinazoline 953039-63-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20tons
Release date: 2019-12-30

953039-63-9, 8-BroMo-2-chloro-6-fluoro-quinazolineRelated Search:

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8-BroMo-2-chloro-6-fluoro-quinazoline

8-Bromo-2-chloro-6-fluoro-quizoline

Quinazoline, 8-bromo-2-chloro-6-fluoro-

953039-63-9

C8H3BrClFN2