ChemicalBook > CAS DataBase List > BML-275

BML-275

Product Name
BML-275
CAS No.
1219168-18-9
Chemical Name
BML-275
Synonyms
CS-1883;Dorsomorph;BML-275(2HCL);Compound C 2HCl;Dorsomorphin HCl;BML-275,Compound C;Nutlin-3a (Rebemadlin);BML-275 dihydrochloride;Dorsomorphin-2HCl BML-275;BML-275 Dorsomorphin 2HCL
CBNumber
CB72614842
Molecular Formula
C24H27Cl2N5O
Formula Weight
472.41008
MOL File
1219168-18-9.mol
More
Less

BML-275 Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥11.34 mg/mL in 0.9% NS ; ≥39.93 mg/mL in DMSO:H2O=2:1 ; ≥5.91 mg/mL in DMSO
form 
Light yellow powder solid.
color 
Yellow
Stability:
Hygroscopic
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
21207
Product name
Dorsomorphin (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21207
Product name
Dorsomorphin (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
21207
Product name
Dorsomorphin (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
21207
Product name
Dorsomorphin (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$343
Updated
2024/03/01
TRC
Product number
D534910
Product name
DorsomorphinDihydrochloride
Packaging
50mg
Price
$425
Updated
2021/12/16
More
Less

BML-275 Chemical Properties,Usage,Production

Description

Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.

Uses

Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.

in vivo

Dorsomorphin (compound C; 10 mg/kg, intravenously once) dihydrochloride treatment leads to a 60% increase in total serum iron concentrations, reduces basal levels of hepcidin expression and increases serum iron concentrations in adult mice[3].
Dorsomorphin (0.2 mg/kg, i.v., 30 min before LPS injection) dihydrochloride reduces ICAM-1 and VCAM-1 expression in LPS-injected rat aorta[4].
Dorsomorphin (25 mg/kg; i.p. injection, in male BALB/c mice) dihydrochloride treatment before lipopolysaccharide (LPS) injection significantly reduces lethality in contrast to animals treated with LPS challenge only[5].

Animal Model:Wild-type (WT) C57BL/6 adult mice that are fed a standard iron-replete diet express high levels of hepcidin[3].
Dosage:10 mg/kg.
Administration:Intravenously once.
Result:Led to a 60% increase in total serum iron concentrations.
Effective in reducing basal levels of hepcidin expression and increasing serum iron concentrations in adult mice.
Animal Model:Male Sprague-Dawley rats, 8 weeks of age (body weight 230-250 g)[4].
Dosage:0.2 mg/kg.
Administration:I.V., 30 min before LPS injection.
Result:Reduced ICAM-1 and VCAM-1 expression in LPS-injected rat aorta.
Animal Model:Male BALB/c mice at 6-7 weeks of age weighing 20-22 g[5]
Dosage:25 mg/kg
Administration:Injection i.p.; 60 min before LPS challenge
Result:Treatment of mice with 25 mg/kg before LPS injection significantly reduced lethality in contrast to animals treated with LPS challenge only.

IC 50

AMPK: 109 nM (Ki); ACVR1; BMPR1A; ALK6; Autophagy

storage

Room temperature (desiccate)

References

[1] ZHOU G, MYERS R W, LI Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action.[J]. The Journal of clinical investigation, 2001, 1 1: 0. DOI: 10.1172/jci13505
[2] PAUL B YU. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism[J]. Nature chemical biology, 2007, 4 1: 33-41. DOI: 10.1038/nchembio.2007.54
[3] LJUBICA VUCICEVIC. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.[J]. Autophagy, 2011, 7 1: 40-50. DOI: 10.4161/auto.7.1.13883

BML-275 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BML-275 Suppliers

China 147 India 2 United Kingdom 2 United States 17 Global 168
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1219168-18-9, BML-275Related Search:

D-ERYTHRO-SPHINGOSINE 3-METHYLADENINE SB 431542 A 769662 AICAR Rapamycin LY 294002 Hydrochloride KU-55933 Selumetinib PLX-4720 CX-4945 Fluoxetine hydrochloride Alpelisib (BYL719) Tubastatin A hydrochloride N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride BI 2536 Neratinib Glucagon Receptor Antagonist I

  • dorsoMorphin (Hydrochloride)
  • DorsoMorphin, Dihydrochloride Salt, >99%
  • BML-275,Compound C
  • 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2) Dorsomorphin 2HCl
  • Dorsomorphin-2HCl BML-275
  • 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2)
  • BML-275 dihydrochloride
  • Dorsomorphin(BML-275)dihydrochloride
  • BML-275(2HCL)
  • Compound C dihydrochloride
  • Dorsomorphin 2HCl (BML-275 2HCl)
  • DORSOMORPHIN (COMPOUND C) 2HCL
  • DORSOMORPHIN 2HCL;BML275.HCL;COMPOUND C
  • Dorsomorph
  • BML-275 Dorsomorphin 2HCL
  • BML-275;COMPOUND C;BML275;BML 275;BML-275 DIHYDROCHLORIDE;COMPOUND C DIHYDROCHLORIDE;BML275 DIHYDROCHLORIDE;BML 275 DIHYDROCHLORIDE
  • 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE;DIHYDROCHLORIDE
  • CS-1883
  • BML-275; COMPOUND C; BML275; BML 275
  • Dorsomorphin HCl
  • Compound C 2HCl
  • Dorsomorphin (Compound C) dihydrochloride
  • Dorsomorphin Dihydrochloride BML-275 BML275
  • Nutlin-3a (Rebemadlin)
  • Dorsomorphin dihydrochloride, AMP-kinase inhibitor
  • Dorsomorphin dihydrochloride, 10 mM in DMSO
  • Dorsomorphin (Compound C) 2HCl ，S7306
  • 1219168-18-9
  • C24H27Cl2N5O
  • C24H25N5O2ClH
  • PI3K/Akt/mTOR
  • Inhibitors
  • Akt
  • mTOR
  • PI3K