BML-275

Product Name: BML-275
CAS No.: 1219168-18-9
Chemical Name: BML-275
Synonyms: CS-1883;Dorsomorph;BML-275(2HCL);Compound C 2HCl;Dorsomorphin HCl;BML-275,Compound C;BML-275 dihydrochloride;Dorsomorphin-2HCl BML-275;BML-275 Dorsomorphin 2HCL;Compound C dihydrochloride
CBNumber: CB72614842
Molecular Formula: C24H27Cl2N5O
Formula Weight: 472.41008
MOL File: 1219168-18-9.mol

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BML-275 Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: insoluble in EtOH; insoluble in H2O; ≥11.34 mg/mL in 0.9% NS ; ≥39.93 mg/mL in DMSO:H2O=2:1 ; ≥5.91 mg/mL in DMSO
form: Light yellow powder solid.
color: Yellow
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21207
Product name: Dorsomorphin (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21207
Product name: Dorsomorphin (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 21207
Product name: Dorsomorphin (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 21207
Product name: Dorsomorphin (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

TRC

Product number: D534910
Product name: DorsomorphinDihydrochloride
Packaging: 50mg
Price: $425
Updated: 2021/12/16

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BML-275 Chemical Properties,Usage,Production

Description

Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; K_i = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.

Uses

Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.

storage

Room temperature (desiccate)

BML-275 Preparation Products And Raw materials

Raw materials

Preparation Products

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BML-275 Suppliers

China 111 India 2 United Kingdom 2 United States 16 Global 131

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
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ProdList: 4861
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
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Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

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Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

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Country: United States
ProdList: 6618
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Santa Cruz Biotechnology, Inc.

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Email: scbt@scbt.com
Country: United States
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NE Scientific

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1219168-18-9, BML-275Related Search:

D-ERYTHRO-SPHINGOSINE 3-METHYLADENINE SB 431542 A 769662 AICAR LY 294002 HYDROCHLORIDE Rapamycin KU-55933 Selumetinib PLX-4720 CX-4945 Fluoxetine hydrochloride Alpelisib (BYL719) Tubastatin A hydrochloride N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride BI 2536 Neratinib Glucagon Receptor Antagonist I

dorsoMorphin (Hydrochloride)

DorsoMorphin, Dihydrochloride Salt, >99%

BML-275,Compound C

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2) Dorsomorphin 2HCl

Dorsomorphin-2HCl BML-275

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2)

BML-275 dihydrochloride

Dorsomorphin(BML-275)dihydrochloride

BML-275(2HCL)

Compound C dihydrochloride

Dorsomorphin 2HCl (BML-275 2HCl)

DORSOMORPHIN (COMPOUND C) 2HCL

DORSOMORPHIN 2HCL;BML275.HCL;COMPOUND C

Dorsomorph

BML-275 Dorsomorphin 2HCL

BML-275;COMPOUND C;BML275;BML 275;BML-275 DIHYDROCHLORIDE;COMPOUND C DIHYDROCHLORIDE;BML275 DIHYDROCHLORIDE;BML 275 DIHYDROCHLORIDE

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE;DIHYDROCHLORIDE

CS-1883

BML-275; COMPOUND C; BML275; BML 275

Dorsomorphin HCl

Compound C 2HCl

Dorsomorphin (Compound C) dihydrochloride

Dorsomorphin Dihydrochloride BML-275 BML275

1219168-18-9

C24H27Cl2N5O

C24H25N5O2ClH

PI3K/Akt/mTOR

Inhibitors

Akt

mTOR

PI3K