XL765

ChemicalBook > CAS DataBase List > XL765

Product Name: XL765
CAS No.: 1349796-36-6
Chemical Name: XL765
Synonyms: CS-1849;PI3K-IN-1;XL765, >=98%;XL147 analog 2;SAR245409 (XL765);Voxtalisib-Analog;Voxtalisib Analogue;Voxtalisib (XL765) Analogue;Voxtalisib (SAR245409, XL765);SAR245409; XL-765;SAR 245409;SAR- 245409
CBNumber: CB72646577
Molecular Formula: C31H29N5O6S
Formula Weight: 599.66
MOL File: 1349796-36-6.mol

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XL765 Property

Density: 1.387±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥15 mg/mL in DMSO
form: solid
pka: 5.88±0.30(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16299
Product name: XL765
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16299
Product name: XL765
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 16299
Product name: XL765
Purity: ≥95%
Packaging: 10mg
Price: $363
Updated: 2024/03/01

Cayman Chemical

Product number: 16299
Product name: XL765
Purity: ≥95%
Packaging: 50mg
Price: $1169
Updated: 2024/03/01

TRC

Product number: X746270
Product name: XL765
Packaging: 25mg
Price: $690
Updated: 2021/12/16

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XL765 Chemical Properties,Usage,Production

Uses

XL765 is a low-molecular mass PI3K inhibitor that also inhibits DNA-PK and mTOR.

Definition

ChEBI: XL765 is a sulfonamide obtained by formal condensation of the sulfonic acid group of 4-[(3-methoxy-4-methylbenzoyl)amino]benzenesulfonic acid with the primary aromatic amino group of N-(3,5-dimethoxyphenyl)quinoxaline-2,3-diamine. A dual PI3K/mTOR inhibitor used in cancer treatment. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an antineoplastic agent and a mTOR inhibitor. It is a sulfonamide, a quinoxaline derivative, an aromatic amine, a member of benzamides and an aromatic ether.

Biological Activity

sar245409 (xl765) is a selective dual inhibitor of pi3k and mtor (ic50= 9 nm for pi3kγ).pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in pa cell lines, combination of xl765 and tmz blocked the cell growth and led to apoptosis [1]. in a variety of tumor cell lines that mutated on pi3k signaling, xl765 inhibited pip3 formation in the membrane and akt/p70s6k/s6 phosphorylation [2].in gh3 xenograft tumor mouse models, combination use of xl765 and tmz inhibited tumor growth, reduced serum gh and prolactin levels with no increased systemic side effects [1]. in severe combined immunodeficient mice, xl765 abolished mpnst local and metastatic growth. [3]. in multiple human xenograft models in nude mice, repeat dose administration showed significant tumor growth inhibition that related to antiproliferative and antiangiogenic response etc. [2]

References

1. dai c, zhang b, liu x et al. inhibition of pi3k/akt/mtor pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude mice. endocrinology. 2013 mar;154(3):1247-59.2. yu p, laird ad, du x et al. characterization of the activity of the pi3k/mtor inhibitor xl765 (sar245409) in tumor models with diverse genetic alterations affecting the pi3k pathway. molcancer ther. 2014 may;13(5):1078-91.3. ghadimi mp, lopez g, torres ke et al. targeting the pi3k/mtor axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors. mol cancer ther. 2012 aug;11(8):1758-69.

XL765 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from XL765 manufacturers

Career Henan Chemical Co

Product: XL765 1349796-36-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

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SAR245409 (XL765)

PI3K-IN-1

N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide

Benzamide, N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-

Voxtalisib (SAR245409, XL765)

N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide SAR245409 (XL765)

XL765 N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide

SAR245409; XL-765;SAR 245409;SAR- 245409

CS-1849

PI3K-IN-1 ;SAR245409;XL-765;SAR 245409;SAR- 245409

N-(4-(N-(3-((3,5-Dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylben

Voxtalisib Analogue

Voxtalisib analogue, 98%, a potent inhibitor of PI3K

N-{4-[3-(3,5-Dimethoxy-phenylamino)-quinoxalin-2-ylsulfamoyl]-phenyl}-3-methoxy-4-methyl-benzamide

XL765, >=98%

Voxtalisib-Analog

Voxtalisib Analog (SAR245409 Analog, XL765 Analog)

XL765 SAR 245409 N-[4-[[[3-[(3-5-Dimethoxyphenyl-amino]

XL147 analog 2

Voxtalisib (XL765) Analogue

1349796-36-6

Akt

mTOR

PI3K

Inhibitors

PI3K/Akt/mTOR