Ethyl (trimethylsilyl)acetate

Product Name: Ethyl (trimethylsilyl)acetate
CAS No.: 4071-88-9
Chemical Name: Ethyl (trimethylsilyl)acetate
Synonyms: ETSA;2-trimethylsilylbutanoate;Ethyl(Trimethylsily)Acetate;ETHYL (TRIMETHYLSILYL)ACETATE;ETHYL(2-TRIMETHYLSILYL)ACETATE;ETHYL TRI METHYLSILYLACETATE 99%;Ethyl (trimethylsilyl)acetate,97%;Ethyl acetatethree Methylsilicone;Ethyl (trimethylsilyl)acetate, 98+%;(TRIMETHYLSILYL)ACETIC ACID ETHYL ESTER
CBNumber: CB7271085
Molecular Formula: C7H16O2Si
Formula Weight: 160.29
MOL File: 4071-88-9.mol

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Ethyl (trimethylsilyl)acetate Property

Boiling point:: 156-159 °C (lit.)
Density: 0.876 g/mL at 25 °C (lit.)
refractive index: n20/D 1.415(lit.)
Flash point:: 95 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: sol ethereal and chlorinated solvents; reacts with protic solvents.
form: clear liquid
color: Colorless to Almost colorless
Specific Gravity: 0.876
Water Solubility: Decomposition
Hydrolytic Sensitivity: 2: reacts with aqueous acid
Sensitive: Moisture Sensitive
BRN: 1755902
CAS DataBase Reference: 4071-88-9(CAS DataBase Reference)
NIST Chemistry Reference: Ethyl (trimethylsilyl)acetate(4071-88-9)

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Safety

Risk Statements: 10
Safety Statements: 16-24/25
RIDADR: UN 3272 3/PG 3
WGK Germany: 3
F: 10-21
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 209120
Product name: Ethyl trimethylsilylacetate
Purity: ≥98%
Packaging: 25g
Price: $244
Updated: 2022/05/15

TCI Chemical

Product number: T1584
Product name: Ethyl (Trimethylsilyl)acetate
Purity: >93.0%(GC)
Packaging: 5g
Price: $54
Updated: 2024/03/01

TCI Chemical

Product number: T1584
Product name: Ethyl (Trimethylsilyl)acetate
Purity: >93.0%(GC)
Packaging: 25g
Price: $162
Updated: 2024/03/01

Alfa Aesar

Product number: A17707
Product name: Ethyl (trimethylsilyl)acetate, 98+%
Packaging: 10g
Price: $59.65
Updated: 2024/03/01

Alfa Aesar

Product number: A17707
Product name: Ethyl (trimethylsilyl)acetate, 98+%
Packaging: 50g
Price: $257
Updated: 2024/03/01

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Ethyl (trimethylsilyl)acetate Chemical Properties,Usage,Production

Chemical Properties

Ethyl trimethylsilylacetate is a clear colorless liquid. It is stable to the usual manipulations, and can be stored in glass containers for years without change of physical and spectral properties.

Uses

(silylating agent; source of an ethyl acetate anion equivalent.Ethyl trimethylsilylacetate is reactive to nucleophiles and readily undergoes desilylation reactions with acid or alkali,ethanol, and bromine.

Uses

Ethyl trimethylsilylacetate is used in the synthesis of ethyl-2,2-dibromo-2-(trimethylsilyl)acetate and α,β-unsaturated esters. It was also used to silylate the enolizable aldehydes and ketones.

Preparation

ethyl trimethylsilylacetate synthesis: Available by a Reformatsky reaction from ethyl bromoacetate, and by reaction of trimethylsilylmethylmagnesium chloride with ethyl chloroformate. An alternative approach requires the treatment of ethyl acetate with triphenylmethylsodium followed by chlorotrimethylsilane The use of a nitrogen base with ethyl acetate in THF followed by reaction with chlorotrimethylsilane results in a mixture of C- and O-silylation. The use of HMPA as additive in the reaction medium increases the amount of O-silylation to 90%. Similar methods can be used to prepare analogs.

General Description

Reaction of ethyl trimethylsilylacetate (ETSA) with dilute hydrochloric acid, dilute alkali, anhydrous HCl, anhydrous bromine and absolute ethanol has been reported. ETSA undergoes condensation with aromatic aldehydes in the presence of base catalyst to yield β-trimethylsiloxycarboxylates. Lithium ETSA reacts with ketones to yield α,β-unsaturated esters.

Purification Methods

Purify it by distilling ca 10g of reagent through a 15cm, Vigreux column (p 11) and then redistilling it through a 21cm glass helices-packed column [Hauze & Hauser J Am Chem Soc 75 994 1953]. Alternatively, dissolve it in Et2O, wash with H2O, dilute Na2CO3, dry over Na2CO3, evaporate Et2O, and distil it through a column of 15 theoretical plates. [Gold et al. J Am Chem Soc 70 2874 1948, Beilstein 4 IV 3974.]

Ethyl (trimethylsilyl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl (trimethylsilyl)acetate Suppliers

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View Lastest Price from Ethyl (trimethylsilyl)acetate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl (trimethylsilyl)acetate 4071-88-9
Price: US $30.00-20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-07-30

Career Henan Chemical Co

Product: Ethyl (trimethylsilyl)acetate 4071-88-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

4071-88-9, Ethyl (trimethylsilyl)acetateRelated Search:

Azidotrimethylsilane POLY(VINYL ACETATE) ETHYL (METHYLTHIO)ACETATE Hexamethyldisilazane N-(Trimethylsilyl)acetamide Ethyl nitroacetate Methyl acetate Trimethylsilylacetylene Sodium acetate Lithium bis(trimethylsilyl)amide Ethyl trifluoroacetate Tocopheryl acetate Ethyl phenylacetate Glatiramer acetate Ethyl acetate Vinyl acetate N-(Trimethylsilyl)imidazole Ethyl chloroacetate

ETHYL 2-(TRIMETHYLSILYL)ACETATE, 97%ETHYL 2-(TRIMETHYLSILYL)ACETATE, 97%ETHYL 2-(TRIMETHYLSILYL)ACETATE, 97%

ETHYL(2-TRIMETHYLSILYL)ACETATE

ETHYL (TRIMETHYLSILYL)ACETATE

ETSA

(TRIMETHYLSILYL)ACETIC ACID ETHYL ESTER

ETHYL TRI METHYLSILYLACETATE 99%

Ethyl(Trimethylsily)Acetate

ETSA~(Trimethylsilyl)acetic acid ethyl ester

2-trimethylsilylbutanoate

Ethyl (trimethylsilyl)acetate, 98+%

2-(Trimethylsilyl)acetic acid ethyl ester

2-[Dimethyl(methyl)silyl]acetic acid ethyl ester

Ethyl (trimethylsilyl)acetate,97%

(Trimethylsilyl)acetic Acid Ethyl Ester ETSA

Ethyl acetatethree Methylsilicone

Acetic acid, (trimethylsilyl)-, ethyl ester

TIANFUCHEM-- 4071-88-9--Ethyl (trimethylsilyl)acetate in stock

4071-88-9

C7H16O2Si

CH33SiCH2CO2CH2CH3

CH33SiCH2CO2C2H5

Carbonyl Compounds

C6 to C7

Building Blocks

Si (Classes of Silicon Compounds)

Silicon Compounds (for Synthesis)

Si-(C)4 Compounds

Organic Building Blocks

Esters

Si (Classes of Silicon Compounds)

Si-(C)4 Compounds

Silicon Compounds (for Synthesis)

Synthetic Organic Chemistry