GNE-9605

ChemicalBook > CAS DataBase List > GNE-9605

Product Name: GNE-9605
CAS No.: 1536200-31-3
Chemical Name: GNE-9605
Synonyms: CS-1831;GNE-9605;GNE-9605 USP/EP/BP;GNE-9605;GNE9605;GNE 9605;Diazepam-d8 (exempt preparation);N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine;rel-N2-(5-Chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-
CBNumber: CB72715631
Molecular Formula: C17H20ClF4N7O
Formula Weight: 449.83
MOL File: 1536200-31-3.mol

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GNE-9605 Property

Boiling point:: 587.9±60.0 °C(Predicted)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≥22.5 mg/mL in DMSO
form: solid
pka: 5.04±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23446
Product name: GNE-9605
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 23446
Product name: GNE-9605
Purity: ≥98%
Packaging: 5mg
Price: $177
Updated: 2024/03/01

Cayman Chemical

Product number: 23446
Product name: GNE-9605
Purity: ≥98%
Packaging: 10mg
Price: $312
Updated: 2024/03/01

Cayman Chemical

Product number: 23446
Product name: GNE-9605
Purity: ≥98%
Packaging: 25mg
Price: $583
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: INB0004681
Product name: N2-(5-CHLORO-1-(3-FLUORO-1-(OXETAN-3-YL)PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)-N4-METHYL-5-(TRIFLUOROMETHYL)PYRIMIDINE-2,4-DIAMINE
Purity: 95.00%
Packaging: 5MG
Price: $497.98
Updated: 2021/12/16

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GNE-9605 Chemical Properties,Usage,Production

Description

GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC₅₀ = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser¹²⁹² autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.

References

[1]. estrada aa, chan bk, baker-glenn c, et al. discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (lrrk2) small molecule inhibitors. j med chem, 2014, 57(3): 921-936.

GNE-9605 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-9605 Suppliers

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1536200-31-3, GNE-9605Related Search:

GNE-3511 GNE-490 GNE-6640 GNF 5837 GNE 477 GNE-955 GNE140 GNE-493 gne-131 GNE 617 GNE 7915 Bortezomib Axitinib RVX-208 Trametinib PD 0332991 HCl Ibrutinib

GNE-9605

N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine

Diazepam-d8 (exempt preparation)

CS-1831

GNE-9605;GNE9605;GNE 9605

2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-

GNE-9605 USP/EP/BP

rel-N2-(5-Chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

1536200-31-3

C17H20ClF4N7O

Inhibitors