ChemicalBook > CAS DataBase List > GNE-9605

GNE-9605

Product Name
GNE-9605
CAS No.
1536200-31-3
Chemical Name
GNE-9605
Synonyms
CS-1831;GNE-9605;GNE-9605 ，S7368;GNE-9605 (GNE9605;GNE-9605 USP/EP/BP;GNE-9605, 10 mM in DMSO;GNE-9605;GNE9605;GNE 9605;Diazepam-d8 (exempt preparation);N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine
CBNumber
CB72715631
Molecular Formula
C17H20ClF4N7O
Formula Weight
449.83
MOL File
1536200-31-3.mol
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GNE-9605 Property

Boiling point:
587.9±60.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
≥22.5 mg/mL in DMSO
form 
solid
pka
5.04±0.60(Predicted)
color 
White to off-white
InChIKey
PUXPEQJKNAWNQA-PZILLZCRNA-N
SMILES
C1(NC2=C(Cl)N([C@@H]3CCN(C4COC4)C[C@H]3F)N=C2)=NC=C(C(F)(F)F)C(NC)=N1 |&1:6,15,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23446
Product name
GNE-9605
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
23446
Product name
GNE-9605
Purity
≥98%
Packaging
5mg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
23446
Product name
GNE-9605
Purity
≥98%
Packaging
10mg
Price
$312
Updated
2024/03/01
Cayman Chemical
Product number
23446
Product name
GNE-9605
Purity
≥98%
Packaging
25mg
Price
$583
Updated
2024/03/01
ApexBio Technology
Product number
B4761
Product name
GNE-9605
Packaging
5mg
Price
$110
Updated
2021/12/16
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GNE-9605 Chemical Properties,Usage,Production

Description

GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.

Uses

GNE-9605 is a potent, orally active, selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 value of 18.7 nM. GNE-9605 inhibits LRRK2 Ser1292 autophosphorylation. GNE-9605 can be used in research of Parkinson's disease (PD) [1].

in vivo

GNE-9605 (10 and 50 mg/kg; i.p.; once) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein[1].
GNE-9605 (1 mg/kg, p.o.; 0.5 mg/kg, i.v.; once) displays LRRK2 Ki in the biochemical assay of 2 nM as well as a cellular IC50 of 19 nM. GNE-9605 has a total plasma clearance with excellent oral bioavailability[1].

Animal Model:BAC transgenic mice expressing human LRRK2 protein[1].
Dosage:10 and 50 mg/kg
Administration:Intraperitoneal injection; once
Result:Inhibited LRRK2 Ser1292 autophosphorylation in a dose-dependent manner.
Animal Model:BAC transgenic mice expressing human LRRK2 protein[1].
Dosage:1 mg/kg, p.o.; 0.5 mg/kg, i.v.
Administration:Oral administration and intravenous injection; once
Result:Demonstrated a total plasma clearance of 26 mL min-1 kg-1 with excellent oral bioavailability (90%).

References

[1]. estrada aa, chan bk, baker-glenn c, et al. discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (lrrk2) small molecule inhibitors. j med chem, 2014, 57(3): 921-936.

GNE-9605 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-9605 Suppliers

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1536200-31-3, GNE-9605Related Search:

GNE-3511 GNE-490 GNE-6640 GNF 5837 GNE 477 GNE-955 GNE140 GNE-493 gne-131 GNE 617 GNE 7915 Bortezomib Axitinib RVX-208 Trametinib PD 0332991 HCl Ibrutinib

  • GNE-9605
  • N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
  • rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine
  • Diazepam-d8 (exempt preparation)
  • CS-1831
  • GNE-9605;GNE9605;GNE 9605
  • 2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-
  • GNE-9605 USP/EP/BP
  • rel-N2-(5-Chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
  • GNE-9605, 10 mM in DMSO
  • GNE-9605 ，S7368
  • GNE-9605 (GNE9605
  • 1536200-31-3
  • C17H20ClF4N7O
  • Inhibitors