4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Product Name: 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
CAS No.: 16673-34-0
Chemical Name: 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
Synonyms: 5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide;NLRP3i;NLRP3-IN-2;Einecs 240-722-5;16673-34-0 NLRP3i;Glyburide USP RC A;Glibenclamide Impurity 7;Glibenclamide EP Impurity A;Glyburide Related CoMpound A;NLRP3 Inflammasome InhibitorⅠ
CBNumber: CB7278059
Molecular Formula: C16H17ClN2O4S
Formula Weight: 368.84
MOL File: 16673-34-0.mol

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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Property

Melting point:: 209-214 °C
Density: 1.356±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 45 mg/ml).
pka: 10.14±0.10(Predicted)
form: Solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI: InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
InChIKey: KVWWTCSJLGHLRM-UHFFFAOYSA-N
SMILES: C(NCCC1=CC=C(S(N)(=O)=O)C=C1)(=O)C1=CC(Cl)=CC=C1OC
CAS DataBase Reference: 16673-34-0(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 23-24-25
Safety Statements: 24/25
WGK Germany: 1
HS Code: 2935909550

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2414
Product name: Glyburide Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $534
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP071
Product name: 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonamide
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 25MG
Price: $266
Updated: 2024/03/01

Sigma-Aldrich

Product number: 463442
Product name: 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
Purity: 95%
Packaging: 5g
Price: $66
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1295516
Product name: Glyburide Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1490
Updated: 2024/03/01

Cayman Chemical

Product number: 30895
Product name: NLRP3i
Packaging: 1g
Price: $62
Updated: 2024/03/01

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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Chemical Properties,Usage,Production

Description

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2

Chemical Properties

Light Yellow Solid

Uses

An impurity arising in the synthesis of Glyburide (G598350).

General Description

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

storage

Store at +4°C

References

1) Fulp?et al.?(2018),?Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem.,?61?5412 2) Marchetti?et al.?(2014),?A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol.,?63?316

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Preparation Products And Raw materials

Raw materials

5-CHLORO-2-METHOXYBENZOYL CHLORIDE 2-METHOXYBENZAMIDE 5-Chloro-2-hydroxybenzoic acid Thionyl chloride 5-Chloro-2-methoxybenzoic acid Dimethyl sulfate

Preparation Products

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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Suppliers

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View Lastest Price from 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide manufacturers

Career Henan Chemical Co

Product: 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide 16673-34-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2019-06-26

16673-34-0, 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamideRelated Search:

Ethyl pyruvate P-AMINOBENZAMIDE GLUTAMIC ACID 2-(2-Aminoethylamino)ethanol Ethylparaben Ethyl acetate Ethyl formate Ethyl cyanoacetate Ethanol Ethyl acrylate Sulfanilamide Benzamide Diphenyl ether ISOXADIFEN-ETHYL PHENYL VALERATE PHENYL RESIN Phenylacetic acid Difluorochloromethane Glibenclamide

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Glyburide Related Compound A (25 mg) (5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide)

4-[2-(2-Methoxy-5-chlorobenzene-1-carboxaMido)ethyl]benzenesulfonaMide

5-Chloro-N-(p-sulfaMoylphenethyl)-o-anisaMide

5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide

GlibenclaMide (Glyburide) IMpurity A

Glyburide Related CoMpound A

Glyburide Related Compound A (25 mg) (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide)

Glyburide USP RC A

5-Chloro-2- methoxy-N-[2-(4-sulphamoylphenyl

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95%

NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome InhibitorⅠ

5-chloro-2-methoxy-n-(2-(4-sulfamoyl-phenyl)ethyl

Glibenclamide Impurity 1(Glibenclamide EP Impurity A)

NLRP3i

N-(2-(4-(Aminosulfonyl)phenyl)ethyl)-5-chloro-2-methoxybenzamide

4-(5-CHLORO-2-METHOXYBENZAMIDOETHYL)BENZENESULFONAMIDE

4-[2-(5-CHLORO-2-METHOXY-BENZAMIDE)ETHYL]-BENZENESULPHONAMIDE

4-(2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL)PHENYLSULFONAMIDE

4-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]PHENYLSULPHONAMIDE

4-[2-(2-METHOXY-5-CHLOROBENZAMIDO)ETHYL]BENZENESULFONAMIDE

5-CHLORO-2-METHOXY-N-[2-(P-SULFAMOYLPHENYL)ETHYL]BENZAMIDE

5-CHLORO-2-METHOXY-N-[2-(4-SULFAMOYLPHENYL)ETHYL]BENZAMIDE

N-(2-(4-sulfamoyl)phenyl)ethyl-5-chloro-2-methoxybenzamide

N-[2-[4-(aminosulphonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide

4-[2-(2-Methoxy-5-Chloro Benzamido)Ethyl]Sulphonamide

[2-(5-Chloro-2.methoxybenzamido)-ethyl]-phenylsulfonamide

4-Ethyl-3-(2-methoxy-5-chlorbenzamido)-benzolsulfonamid

4-2-(5-CHLORO-2-METHOXYBENZAMIDO)-ETHYL BENZENSULFONAMIDE

BENZAMIDE, N-[2-[4-(AMINOSULFONYL) PHENYL]ETHYL]-5-CHLORO-2-METHOXY (GLYBIN SULFONAMIDE)

Einecs 240-722-5

N-[4-(Aminosulfonyl)phenethyl]-2-methoxy-5-chlorobenzamide

Glyburide USP Related Compound A

Glibenclamide (Glyburide) EP Impurity A

Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide

5-chloro-2-methoxy-N-[2-(4-sulphamoylphenyl)ethyl]benzamide

Glibenclamide EP Impurity A

5-Chloro-2-methoxy-N-[2-(4-sulfamoy

16673-34-0 NLRP3i

Benzamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxy-

NLRP3-IN-2

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide ISO 9001：2015 REACH

Glibenclamide EP Impurity A/ Glyburide Related Compound A

Glibenclamide EP Impurity AQ: What is Glibenclamide EP Impurity A Q: What is the CAS Number of Glibenclamide EP Impurity A Q: What is the storage condition of Glibenclamide EP Impurity A Q: What are the applications of Glibenclamide EP Impurity A

Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide

Glyburide Related Compound A (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) (1295516)

Glibenclamide Impurity 7

Sulphonamide of Glibenclamide

Glibenclamide (Glyburide) EP Impurity A (Glibenclamide (Glyburide) USP Related Compound A)

5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide|||NLRP3 Inflammasome Inhibitor I

Glibenclamide Impurity Ⅰ(4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide)

16673-34-0

C16H17ClN2O4S

ClC6H3OCH3CONHCH2C6H4SO2NH2

C16H17N2O4ClS

36884

Sulfur Compounds