ChemicalBook > CAS DataBase List > 4-Cyanobenzyl bromide

4-Cyanobenzyl bromide

Uses Chemical Properties

Product Name: 4-Cyanobenzyl bromide
CAS No.: 17201-43-3
Chemical Name: 4-Cyanobenzyl bromide
Synonyms: 4-(BROMOMETHYL)BENZONITRILE;Para Cyano Benzyl Bromide;A-BROMO-P-TOLUNITRILE;4CNBB;NSC 95792;AKOS BC-3028;4-Cyanobenzyl;AKOS BBS-00003970;4-Cyanobezyl Bromide;4-Cynobenzyl bromide
CBNumber: CB7279647
Molecular Formula: C8H6BrN
Formula Weight: 196.04
MOL File: 17201-43-3.mol

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4-Cyanobenzyl bromide Property

Melting point:: 115-117 °C(lit.)
Boiling point:: 143 °C / 12mmHg
Density: 1.5466 (rough estimate)
refractive index: 1.6550 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
color: Clear colorless to yellow
Water Solubility: Soluble in chloroform and methanol. Insoluble in water.
BRN: 636717
InChI: InChI=1S/C8H6BrN/c9-5-7-1-3-8(6-10)4-2-7/h1-4H,5H2
InChIKey: UMLFTCYAQPPZER-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(CBr)C=C1
CAS DataBase Reference: 17201-43-3(CAS DataBase Reference)
NIST Chemistry Reference: «ALPHA»-bromo-p-tolunitrile(17201-43-3)
EPA Substance Registry System: Benzonitrile, 4-(bromomethyl)- (17201-43-3)

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Safety

Hazard Codes: C
Risk Statements: 34-42/43
Safety Statements: 22-26-36/37/39-45-28A
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 10-19-21
Hazard Note: Corrosive
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 144061
Product name: 4-(Bromomethyl)benzonitrile
Purity: 99%
Packaging: 1g
Price: $37.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 144061
Product name: 4-(Bromomethyl)benzonitrile
Purity: 99%
Packaging: 10g
Price: $120
Updated: 2025/07/31

TCI Chemical

Product number: C1398
Product name: 4-Cyanobenzyl Bromide
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $103
Updated: 2025/07/31

TCI Chemical

Product number: C1398
Product name: 4-Cyanobenzyl Bromide
Purity: >98.0%(GC)(T)
Packaging: 250g
Price: $465
Updated: 2025/07/31

Sigma-Aldrich

Product number: 144061
Product name: 4-(Bromomethyl)benzonitrile
Purity: 99%
Packaging: 50g
Price: $350
Updated: 2025/07/31

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4-Cyanobenzyl bromide Chemical Properties,Usage,Production

Uses

4-Cyanobenzyl bromide is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.

Chemical Properties

4-Cyanobenzyl bromide (C8H6BrN, CAS registry No. 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.

Chemical Properties

white to light yellow crystal powde

Uses

A benzyl halide as postemergence herbicides.

Uses

4-(Bromomethyl)benzonitrile is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.

Uses

4-(Bromomethyl)benzonitrile may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.

General Description

4-(Bromomethyl)benzonitrile reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile.

Synthesis

874-89-5

17201-43-3

GENERAL METHOD: Hydroxymethyl (1 mmol) and potassium bromide (1.5 mmol, 0.18 g) were dissolved in ethanol (5 mL) and phosphorus pentoxide (1.5 mmol, 0.23 g) was added. The reaction mixture was stirred at room temperature until the reaction was complete (monitored by TLC or GC). After completion of the reaction, the mixture was filtered and the residue was washed with ethyl acetate (3 x 8 mL). The organic layers were combined, washed with water (10 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude 4-cyanobenzyl bromide product. If further purification is required, column chromatography can be used.

References

[1] Tetrahedron Letters, 2016, vol. 57, # 2, p. 168 - 171
[2] Organic Letters, 2015, vol. 17, # 15, p. 3810 - 3813
[3] Advanced Synthesis and Catalysis, 2016, vol. 358, # 11, p. 1731 - 1735
[4] Patent: US6384080, 2002, B1

4-Cyanobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 4-(4-FORMYLBENZYL)PIPERAZINE-1-CARBOXYLATE Letrozole

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View Lastest Price from 4-Cyanobenzyl bromide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Cyanobenzyl bromide 17201-43-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-04-07

Hebei Zhanyao Biotechnology Co. Ltd

Product: 4-Cyanobenzyl bromide 17201-43-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-19

Career Henan Chemical Co

Product: 4-Cyanobenzyl bromide 17201-43-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-09

17201-43-3, 4-Cyanobenzyl bromideRelated Search:

Methyl 4-cyanobenzoate 4-Cyanobenzoyl chloride Ethidium bromide 4-Cyanophenol Sodium bromate Rocuronium bromide ETHYL 2-CYANOACRYLATE Sodium cyanoborohydride Ethyl cyanoformate 2-Cyanoacetamide Methylene dithiocyanate Diethylstilbestrol Benzyl bromide Allyl bromide Cyanoacetic acid α-Lipoic Acid 2-Fluoro-4-cyanobenzyl bromide Bromine

4-(bromomethyl)-benzonitril

4-(BROMOMETHYL)BENZONITRILE

4CNBB

4-CYANOBENZYL BROMIDE

Benzonitrile, 4-(bromomethyl)-

Benzonitrile, p-(bromomethyl)-

p-(Bromomethyl)benzonitrile

p-Tolunitrile, alpha-bromo-

p-Toluonitrile, alpha-bromo-

P-CYANOBENZYL BROMIDE

A-BROMO-P-TOLUNITRILE

AKOS BBS-00003970

AKOS BC-3028

4-Bromomethyl benzonitrie

CYANOBENZYLBROMIDE(P-)

BROMO(ALPHA-)-P-TOLUNITRILE

4-Cyanobenzyl broMide SynonyMs alpha-BroMo-p-tolunitrile

ALPHA-BROMO-P-TOLUNITRILE

ALPHA-BROMO-P-TOLUONITRILE

4-(Bromomethyl)benzonitrile/alpha-Bromo-p-tolunitrile

4-Cyanobenzylbromide/4-CNBB

4-Cyanobenzyl

à-bromo-p-tolunitrile

a-Bromo-p-toluonitrile.

4-Cyanobenzyl bromide 98%

4-Bromomethylbenzonitribe

alpha-bromo-para-tolunitrile

a-Bromo-p-tolunitrile, (4-Cyanobenzyl bromide)

NSC 95792

α-Bromo-p-tolylnitrile

α-Bromo-p-tolunitrile, 4-Cyanobenzyl bromide

4-Cyanophenyl)methyl bromide

a-Bromo-p-toluenecarbonitrile

4-Cyanobenzyl bromide ,98%

α-Bromo-4-cyanotoluene

alpha-Bromo-p-tolunitrile,98%

4-(bromomethy)benzonitrile

4-Cyano benzyl broMide (P-Cyano benzyl broMide)

4-Cyanobenzyl bromide, alpha-Bromo-p-tolunitrile

4-(broMoMrthyl)-benaonitril

a-Bromo-p-tolylnitrile

4-bromomethyl benzoic nitrile

p-Cyanobenzyl Bromide 4-(Bromomethyl)Benzonitrile

4-Cyanobenzyl bromide 4-bromomethyl benzonitrile

4-Cyanobenzyl Bromide &gt

4-Cyanobezyl Bromide

4-(BROMOMETHYL)BENZONITRILE 1

4-Cyanobenzyl bromide ISO 9001：2015 REACH

Para Cyano Benzyl Bromide

4-Cyanobenzyl bromide 17201-43-3

4-Bromomethyl Benzonitrile/4-Cyano Benzyl Bromide

4-Cynobenzyl bromide

4-(Bromomethyl)benzonitrile, 98%

17201-43-3

17301-43-3

17201-43-4

BENZYL HALIDE