ChemicalBook > CAS DataBase List > 5-Bromo-2-iodopyrimidine

5-Bromo-2-iodopyrimidine

Product Name
5-Bromo-2-iodopyrimidine
CAS No.
183438-24-6
Chemical Name
5-Bromo-2-iodopyrimidine
Synonyms
2-broMo-5-iodopyriMidine;5-Bromo-2-iod;5-bromo-2-iodimidine;5-Brom-2-iodpyrimidin;5-Bromo-iodopyrimidine;5-bromo-2-iodopyrimine;5-Brmo-2-iodopyrimidine;5-BROMO-2-IODOPYRIMIDINE;5-Bromo-2-iodo-1,3-diazine;Pyrimidine, 5-bromo-2-iodo-
CBNumber
CB7281811
Molecular Formula
C4H2BrIN2
Formula Weight
284.88
MOL File
183438-24-6.mol
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5-Bromo-2-iodopyrimidine Property

Melting point:
99-103 °C (lit.)
Boiling point:
341.0±34.0 °C(Predicted)
Density 
2.495±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-2.56±0.22(Predicted)
form 
Crystalline Powder
color 
White to tan
Sensitive 
Light Sensitive
InChI
InChI=1S/C4H2BrIN2/c5-3-1-7-4(6)8-2-3/h1-2H
InChIKey
ZEZKXPQIDURFKA-UHFFFAOYSA-N
SMILES
C1(I)=NC=C(Br)C=N1
CAS DataBase Reference
183438-24-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/38-36/37/38
Safety Statements 
26-37/39-37
WGK Germany 
3
HazardClass 
IRRITANT, LIGHT SENSITIVE
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
637750
Product name
5-Bromo-2-iodopyrimidine
Purity
97%
Packaging
1g
Price
$46.47
Updated
2025/07/31
TRC
Product number
B683740
Product name
5-Bromo-2-iodopyrimidine
Packaging
5g
Price
$195
Updated
2021/12/16
TRC
Product number
B683740
Product name
5-Bromo-2-iodopyrimidine
Packaging
25g
Price
$635
Updated
2021/12/16
Apolloscientific
Product number
OR5851
Product name
5-Bromo-2-iodopyrimidine
Packaging
5g
Price
$16
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB11951
Product name
5-Bromo-2-iodopyrimidine
Packaging
25g
Price
$50
Updated
2021/12/16
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5-Bromo-2-iodopyrimidine Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

5-Bromo-2-iodopyrimidine can be used to synthesize 5,5′-dibromo-2,2′-bipyrimidine and O,O′-dimethyl hyrtinadine A.

General Description

5-Bromo-2-iodopyrimidine can be synthesized by reacting 5-bromo-2-chloropyrimidine with hydroiodic acid.

Synthesis

32779-36-5

183438-24-6

General procedure for the synthesis of 5-bromo-2-iodopyrimidine from 5-bromo-2-chloropyrimidine: 5-bromo-2-chloropyrimidine (5.80 g, 30 mmol) and sodium iodide (7.5 g, 50 mmol) were suspended in chloroform (20 mL), and hydriodic acid (57 wt%, 2.85 g, 25.6 mmol) was slowly added at 0 °C. After cooling was withdrawn, the reaction mixture was stirred at room temperature for 20 hours. Subsequently, the reaction mixture was poured into a mixture of 200 mL of ice water with 30 mL of 10 N sodium hydroxide solution. Chloroform (150 mL) was added and stirred for 10 minutes. The organic phase was separated and the aqueous layer was extracted with chloroform (2 x 100 mL). The organic phases were combined, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give 5-bromo-2-iodopyrimidine as a light yellow solid. Yield: 6.29 g (84%). Mass spectrum (MS): M = 284.8 (ESI+). 1H-NMR (300 MHz, CDCl3): δ 8.54 (s, 2H), 7.56 (d, J = 16.4 Hz, 1H), 7.59-7.66 (m, 4H).

References

[1] Angewandte Chemie - International Edition, 1999, vol. 38, # 5, p. 659 - 661
[2] Patent: US2005/222228, 2005, A1. Location in patent: Page/Page column 15-16
[3] Chemical Communications, 1996, # 24, p. 2719 - 2720
[4] Patent: US2012/238751, 2012, A1. Location in patent: Page/Page column 30
[5] Patent: WO2014/43272, 2014, A1. Location in patent: Paragraph 0411; 0412; 0413

5-Bromo-2-iodopyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-iodopyrimidine Suppliers

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View Lastest Price from 5-Bromo-2-iodopyrimidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Bromo-2-iodopyrimidine 183438-24-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Bromo-2-iodopyrimidine 183438-24-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Henan Aochuang Chemical Co.,Ltd.
Product
5-Bromo-2-iodopyrimidine 183438-24-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27

183438-24-6, 5-Bromo-2-iodopyrimidineRelated Search:

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  • 5-BROMO-2-IODOPYRIMIDINE
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  • 5-Brmo-2-iodopyrimidine
  • 5-bromo-2-iodopyrimine
  • 5-BroMo-2-iodopyriMidine (This product is unavailable in the U.S.)
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  • 5-<WBR>BroMo-<WBR>2-<WBR>iodopyriMidine
  • 5-Bromo-2-iod
  • 5-Bromo-2-iodopyrimidine (This product is unavailable in the U.S.)&gt
  • Pyrimidine, 5-bromo-2-iodo-
  • 5-Bromo-2-iodopyrimidine ISO 9001：2015 REACH
  • 5-Brom-2-iodpyrimidin
  • 5-bromo-2-iodimidine
  • 5-Bromo-2-iodopyrimidine, 99%
  • 183438-24-6
  • 83438-24-6
  • 138438-24-6
  • Building Blocks
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  • Pyrimidines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrimidine
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
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