ChemicalBook > CAS DataBase List > 2,5-Bis(trifluoromethyl)nitrobenzene

2,5-Bis(trifluoromethyl)nitrobenzene

Product Name
2,5-Bis(trifluoromethyl)nitrobenzene
CAS No.
320-88-7
Chemical Name
2,5-Bis(trifluoromethyl)nitrobenzene
Synonyms
2,5-DI(TRIFLUOROMETHYL)NITROBENZENE;2,5-BIS(TRIFLUOROMETHYL)NITROBENZENE;2-NITRO-1,4-BIS(TRIFLUOROMETHYL)BENZENE;1-NITRO-2,5-BIS(TRIFLUOROMETHYL)BENZENE;1,4-BIS(TRIFLUOROMETHYL)-2-NITROBENZENE;2,5-Bis(trifluoromethyl)nitrobenzene97%;2,5-Bis(trifluoromethyl)nitrobenzene 97%;Benzene, 2-nitro-1,4-bis(trifluoromethyl)-;1-Nitro-2,5-bis(trifluoromethyl)benzene>2-Nitro-1,4-bis(trifluoromethyl)benzene,98%
CBNumber
CB7281886
Molecular Formula
C8H3F6NO2
Formula Weight
259.11
MOL File
320-88-7.mol
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2,5-Bis(trifluoromethyl)nitrobenzene Property

Boiling point:
70-75 °C (15 mmHg)
Density 
1.57
refractive index 
1.4235-1.4255
Flash point:
77 °C
storage temp. 
2-8°C
solubility 
Chloroform, Methanol
form 
Liquid
color 
Pale yellow to yellow
Sensitive 
Light Sensitive
CAS DataBase Reference
320-88-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38
Safety Statements 
37/39-26-60-37-23
HazardClass 
TOXIC
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B2546
Product name
1-Nitro-2,5-bis(trifluoromethyl)benzene
Purity
>98.0%(GC)
Packaging
5g
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
B2546
Product name
1-Nitro-2,5-bis(trifluoromethyl)benzene
Purity
>98.0%(GC)
Packaging
25g
Price
$78
Updated
2025/07/31
TRC
Product number
B591783
Product name
2,5-Bis(Trifluoromethyl)nitrobenzene
Packaging
250mg
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0017778
Product name
2,5-BIS(TRIFLUOROMETHYL)NITROBENZENE
Purity
95.00%
Packaging
1G
Price
$621.16
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0017778
Product name
2,5-BIS(TRIFLUOROMETHYL)NITROBENZENE
Purity
95.00%
Packaging
5G
Price
$925.39
Updated
2021/12/16
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2,5-Bis(trifluoromethyl)nitrobenzene Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

2,5-Bis(Trifluoromethyl)nitrobenzene can be prepared to be used as antifungal agents.

Synthesis

433-19-2

320-88-7

General Steps: Example 2: Using 2,3-difluorotoluene as raw material, adopting the same reaction conditions as in Example 1, but replacing 96 mass% sulfuric acid with fuming sulfuric acid with a sulfur trioxide concentration of 10 mass%, the reaction was stirred at 80° C. for 8 hours to obtain 2,5-bis(trifluoromethyl)nitrobenzene in a yield of 68.7%. Example 4: Using 2,3-difluorotoluene as raw material, the same reaction conditions as in Example 1 were used, but 96 mass% of sulfuric acid was replaced with fuming sulfuric acid having a sulfur trioxide concentration of 10 mass%, and 97 mass% of fuming nitric acid was replaced with 98 mass% of concentrated nitric acid, and the reaction was stirred at 80°C for 10 hours to obtain 2,5-bis(trifluoromethyl)nitrobenzene in a yield of 65.3%. Example 7 (Comparative Example): Using 2,3-difluorotoluene as raw material and the same reaction conditions as in Example 1, but replacing 96 mass% sulfuric acid with fuming sulfuric acid with a sulfur trioxide concentration of 24 mass%, 2,5-bis(trifluoromethyl)nitrobenzene was obtained in a yield of 32.5%.

References

[1] Patent: EP1468983, 2004, A1. Location in patent: Page 6
[2] Patent: EP1468983, 2004, A1. Location in patent: Page 5; 6
[3] Journal of the American Chemical Society, 1953, vol. 75, p. 4967
[4] Journal of Organic Chemistry, 1995, vol. 60, # 22, p. 7348 - 7350
[5] Patent: WO2011/150156, 2011, A2. Location in patent: Page/Page column 132

2,5-Bis(trifluoromethyl)nitrobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Bis(trifluoromethyl)nitrobenzene Suppliers

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View Lastest Price from 2,5-Bis(trifluoromethyl)nitrobenzene manufacturers

Career Henan Chemical Co
Product
2,5-Bis(trifluoromethyl)nitrobenzene 320-88-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-09

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